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Selective SDRI? Surely this has potential?

C

cannibalsnail

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Sep 18, 2011
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Its generally accepted that Serotonin and Dopamine are the interesting parts of an entactogen and Norepinephrine mainly serves to produce stimulation and vasoconstriction. Would a selective SDRI e.g. http://en.wikipedia.org/wiki/UWA-101 have any abuse potential?

Its duration isn't listed but as shown with other compounds (4-MMC, Ethylphenidate, I'm sure there are others) increasing selectivity for non NE targets improved subjective effects. Other SDRIs are considered "enjoyable" e.g. Cocaine, Methylone and DRIs as well: EPH, MXE. Could this transfer to UWA-101?
 
The main issue is that releasers feel vastly different from reuptake inhibitors (serotonergic RELEASE being necessary for entactogenesis). A dopaminergic stimulant with significant affinity for SERT would likely be pretty fun (see cocaine). However, an SRI with secondary activity activity at dopamine would not likely be very fun (see prozac and fluoro-tropocaine).

ebola
 
It appears to be more selective for Dopamine while retaining some SERT affinity. And its duration isn't that of SSRIs due to metabolic reduction via the MD ring.
 
Serotonin release should mediate dopaminergic effects, it definitely may diminish compulsiveness, sexual desire(I mean lust not "love" feeling), paranoia, obsessive movements and ego boost, however, it depends on relations between powers of DA/5-HT release, and an overall activation of serotonergic receptors in different parts of the brain.
On a paper it sounds very "nice", like I will definitely test it if it will be avaliable.
I also do think that it will be covered by so-called analogue laws in countries like Russia, UK, USA.
Damn those stupid motherfuckers scheduled modafinil in the same position as as Ketamine in Russia, and it was not introduced to legal market because of bureaucracy, so for now I cannot easily buy it from the smart shop. Putin must die slowly and painfully...
 
Damn me(my concentration is poor due to benzos), it is an Reuptake Inhibitor, not Releaser, so I may be wrong. However, I do think that this drug can be enjoyable. :)
 
cannibalsnail said:
What are you saying? Norepinephrine reuptake inhibitors calm you down?
Click to expand...

The three main monoamine neurotransmitters (DA, NE & SERT) seem to mediate each-other's effects. There is a relative discrepancy of phenotypical-action with what amount of free quantities in proportion there are. Like Neapolitan ice cream, all together they all still do something, but the distinct effect of any one is diminished as equivalent levels of the others are present, almost cancelling the 'magic' of any given single one on its own.

EDIT:

I do find the phenyltropane RTI-83 4-(cis-propenyl) analogue to be highly interesting; "having Ki values of 15 nM at DAT and 7.1 nM at SERT, vs 28,000 nM at NET." Now to have a good study of the human subjective effects thereof, or perhaps tinker with the molecule enough to just edge the DAT affinity out to better than that of the SERT, without compromising the great distancing of them both from NET.

As for a refresher on indirect monoamine agonist Ki values, (the aforementioned link) I found pleasing to read over.
 
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I would assume the ecstasy (no pun inteded) produced by MDMA would have a key noradrengeric component, but what about the anxiolytic and 'peace' effects of MDMA? Are these attenuated or even enhanced by blocking the NE release?

Anyone here rolled while prescribed Starttera?
 
I figured that would be the case as 5HT1A activation amongst other things causes oxytocin release. I wonder if a drug that causes selective serotonin release would have the "loved up" effects of MDMA, but lacking in the ecstasy. Fenfluramine?
 
I'm pretty sure MDMA & methylone share a unique combination of activity @ 5-HT1a, 5-HT2a/b/c, NET, DAT, VMAT & SERT that results in the "magic" of the experience. Selective serotonin releasing agents like MDAI, 5-IAI et cetera did not pan out to be as euphoric/magical as expected.
 
Well MDAI isn't a 5HT1A agonist. And entactogens only become euphoric through mixed dopamine/serotonin release. Mix MDAI with a dopaminergic and it totally changes.
 
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