Recruiting Seeking US adults with experience using SR-17018 for anonymous Johns Hopkins online survey study

Tronica

Tronica

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I am Austin Zamarripa, Ph.D., an Assistant Professor at Johns Hopkins University School of Medicine, and we are conducting a research study seeking adult volunteers in the US to complete an online survey about SR-17018 use. We want to learn more about experiences individuals feel when using SR-17018.

This study has received ethical clearance from the Johns Hopkins Medicine IRB with the assigned protocol number: IRB00557700. Study recruitment is currently open beginning June 2026. The study is expected to remain open until approximately October 2026, or until recruitment is complete.

If you have experiences trying and using SR-17018, whether for recreational or medicinal purposes (e.g., self-treatment for opioid use disorder), you may be eligible to complete the survey.

The survey is anonymous and does not collect personal health information about you. Completion times will vary based on substance use experiences, but we estimate the survey to take approximately 15-25 minutes to complete.

There is no treatment as part of this study and survey completion is not compensated. There are no costs to complete the survey. If you are interested in volunteering to complete this online survey, please see the link below. Using the below link will provide you with additional information and access to the survey.

https://jhmi.co1.qualtrics.com/jfe/form/SV_6WGVPz8jn4SDu0S

Thank you!
The Principal Investigator for this study is C. Austin Zamarripa, Ph.D.
Institution: Johns Hopkins University School of Medicine
Contact Email: [email protected]
JHU Study Protocol: IRB00557700
 
We'd also like to thank Austin and his team for supporting Bluelight through a banner ad.

We'd like to encourage anyone here who has experience with this novel substance to complete this survey.

Please also include any questions or concerns in this thread, thanks.
 
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How do you know they used SR 17018 ? They buy it from “dealers in internet”. Do you send your tested product to those users ? Otherwise how can you be sure it is exactly sr 17018 ?
 
Ban.Zai said:
How do you know they used SR 17018 ? They buy it from “dealers in internet”. Do you send your tested product to those users ? Otherwise how can you be sure it is exactly sr 17018 ?
Click to expand...
you dont, this is a survey study
 
Those excessive chloride functional groups are concerning. I have researched drugs of any known class, from (obscure) opioid derivatives to stimulants and one constant that is always present with halogenated compounds is their incredible toxicity, which increases exponentially the more of those functional groups are halogens. I have been often tempted to design chloro/bromo/iodo opioid derivatives since halogenated opioids often show very interesting traits that non-halogenated ones do not have and could therefore be the "holy grail" to many of the problems associated with chronic opioid use, but what's the point of ending up with an agonist that potentially solves tolerance, when that molecule's metabolic product(s) are slowly eating up your brain/liver/bones/etc. from the inside out?
Iodine-based compounds tend to be the safest, since they "only" ever mess with your thyroid gland, but is a life without tolerance still worth having to deal with insomnia, mood swings, obesity, tachycardia, etc.?

I have observed the following halogen-specific toxicities from reading papers on compounds that contain such functional groups:
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1. Fluoride-based compounds are cardio- and osteotoxic. They are so by virtue of fluoride stimulating the body's cells to release calcium, which in turn prevents the body from employing that calcium to create hydroxyapatite which is literally the building material of our bones and teeth. This leads to a gradual decline in the subject's bone and dental health. Since calcium is also the critical component that helps modulate the heartbeat by virtue of it being an electric messenger of sorts, a lack thereof can be fatal. An awful lot of pharmaceuticals with fluoro groups are responsible for heart diseases. Fluoride also tends to lower IQ levels.​
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2. Chloride-based compounds are notoriously neurotoxic. A famous drug that was touted as "safe and effective" for decades was (hydroxy)chloroquine, which caused everything from direct nerve damage (exponentially increasing rate of blindness, beginning from <1% for the first five years of taking HCQ and nearly 20% after 20 years of chronic use!!! Source: https://www.allaboutvision.com/conditions/related/hydroxychloroquine-eye-side-effects/) to schizophrenia, neuropathic pain, and other nerve related issues.​
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3. Bromide-based compounds are mainly cytotoxic, but also affect your brain, especially the parts that are responsible for attention and memory (in other words, people with AD(H)D shouldn't touch this stuff). Brominated compounds are excellent fire retardants, degreasers and dry cleaners, but they really shouldn't be used in pharmaceuticals. The dangers of brominated agonists are largely identical to the symptoms of a condition known as bromism: skin rashes, chronic fatigue, poor focus or short attention span, impaired memory, speech problems, etc. Also, here is an interesting observation: this study here, in which a patient developed Bromism by excessive cola consumption, states that he had significantly elevated levels of serum chloride (see https://pubmed.ncbi.nlm.nih.gov/9140329/). It turns out that this is so because our body is unable to differentiate between bromide and chloride atoms, which leads to a falsely high chloride reading, masking the real culprit, because our kidneys strongly prefer bromide over chloride. When filtering our blood, they actively reabsorb bromide and throw out the extra chloride (source: https://www.sciencedirect.com/topics/medicine-and-dentistry/bromine-derivative). This would explain why many of the symptoms of bromide poisoning mimic those of chloride poisoning (neurotoxicity)!!!​
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4. Iodide-based compounds I have already explained above.​


I'm not saying that people shouldn't take what works for them and their troubles, but be aware that it WILL come with a price. Maybe not today, maybe not tomorrow, but it most certainly will when dealing with halogenated compounds.

Take care,
Opiophiliclab
 
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