Opioids Searching for something nice to combine with morphine

[andrey]

Hey guys, im into morphine and once per week Im enjoying a pleasant high. Sometimes I drink a beer at the end of the trip, or I combine it with a little bit of caffeine, piperin, magnesium or agmatine. But these substances dont significantly affect the trip for me.

In a few posts, I read that people like to combine opioids especially with anti histamines. Thats why, Im asking you if there is a nice anti histamine you can recommend for the combination with morphine. if there is any other (pharma) drug, you prefer, you can also mention it.

Im not planning on taking it regularly now, just occasionally to sweeten the warmth of the morphine feeling. Thanks for any help.

 

[SotPoker1012]

Antihistamines don't potentiate opioids at all, but they can be synergistic if your goal is to nod out or go to bed. Most people use benadryl or promethazine for this, but I prefer hydroxyzine as its much cleaner sedation. Benadryl always leaves me with a kind of toxic feeling. Its also healthier at large doses and doesn't have the risk of hallucinations.

Hydroxyzine is super easy to get, its given out for mild anxiety quite a bit.

I don't think any of these are going to contribute to that characteristic opioid warmth/euphoria though. YMMV though.

 

[andrey]

Antihistamines don't potentiate opioids at all, but they can be synergistic if your goal is to nod out or go to bed. Most people use benadryl or promethazine for this, but I prefer hydroxyzine as its much cleaner sedation. Benadryl always leaves me with a kind of toxic feeling. Its also healthier at large doses and doesn't have the risk of hallucinations.

Hydroxyzine is super easy to get, its given out for mild anxiety quite a bit.

I don't think any of these are going to contribute to that characteristic opioid warmth/euphoria though. YMMV though.

Yes man, I also hate diphenhydramine, it creates such a dislikable feeling for me. I once tried chlorphenamin and it felt like it potentiated the warming feeling of morphine a bit. The morphine high itself is pretty sedating, perhaps thats the reason why it can be combined quite nice with a sedating anti histamine.

Somewhere on here, I also read that people like to take cyclizine with their opioid.
Thanks for the info, I will look into hydroxyzine. Of course it wont push the opioid euphoria any further, but anti histamines seem to help me get into a dreamy state. And the more relaxed and hals asleep I am, the better my morphine turn.

 

[SotPoker1012]

Yes man, I also hate diphenhydramine, it creates such a dislikable feeling for me. I once tried chlorphenamin and it felt like it potentiated the warming feeling of morphine a bit. The morphine high itself is pretty sedating, perhaps thats the reason why it can be combined quite nice with a sedating anti histamine.

Somewhere on here, I also read that people like to take cyclizine with their opioid.
Thanks for the info, I will look into hydroxyzine. Of course it wont push the opioid euphoria any further, but anti histamines seem to help me get into a dreamy state. And the more relaxed and hals asleep I am, the better my morphine turn.

Yeah, hydroxyzine will definitely contribute to a dreamy, sleepy feeling.
Personally I ended up with more hydroxyzine than I'll ever use because I went to a cheap online telehealth psychiatrist and told them I needed something for anxiety and panic attacks, that wasn't addictive. (I was coming off benzos but didn't want being an addict on my medical record so I didn't tell them that)
I only used it regularly for the first month, but I saw her 3 more times over a year to get more. I ended up with over 200 hydroxyzine pills that way. Most of these places are just pill farms trying to make money so they don't ask many questions. My appointments were sub 5 minutes after the initial consultation.

If you have insurance this is probably the cheapest way to get it. If not, its not a controlled substance so you can likely get it from certain online pharmacies.

To the mods: I'm sorry if this counts as sourcing talk. Since its not a controlled substance and I didn't give specifics like names, I'm not sure if it counts. Feel free to delete or edit this if it does.

 

[paranoid android]

Antihistamines don't potentiate opioids at all, but they can be synergistic if your goal is to nod out or go to bed. Most people use benadryl or promethazine for this, but I prefer hydroxyzine as its much cleaner sedation. Benadryl always leaves me with a kind of toxic feeling. Its also healthier at large doses and doesn't have the risk of hallucinations.

Hydroxyzine is super easy to get, its given out for mild anxiety quite a bit.

I don't think any of these are going to contribute to that characteristic opioid warmth/euphoria though. YMMV though.

Hydroxyzine isnt that easy to get here. I couldnt even get it off the doctor i managed to get fucking dilaudid 4's and fentanyl patches off ffs. However the much inferior promethazine is otc. Doxylamine is also a good one. I personally hate benadryl

 

[SotPoker1012]

Hydroxyzine isnt that easy to get here. I couldnt even get it off the doctor i managed to get fucking dilaudid 4's and fentanyl patches off ffs. However the much inferior promethazine is otc. Doxylamine is also a good one. I personally hate benadryl

That's really strange. Its safer than benadryl which is otc. They give it out like candy in my area. (US, Texas)

Honestly there's no reason hydroxyzine shouldn't be OTC. Its safe, not addictive. I guess because its used more for anxiety than allergies they don't think it needs to be OTC.

I suggest you look into getting it imported if you really want some. I'm already veering awfully close to sourcing and I don't know the rules about legal substance sourcing, so I won't name names, but its pretty easy to find vendors for it from India, etc

 

[KetWise]

Hydroxyzine cleaner kinda anxiolytic too.. used to do insane amounts of it with methadone a while ago.
In comparaison promethazine/dph are really lacking only this sleepy groggy feeling, clearly dysphoric for promethazine ..
those days if I take an antihistamine it's hydroxyzine 50-100 mg, I tried 75mg of prometh the other day and frankly i regretted it, sleepy and groggy but not in a good way. maybe 25 is enough dunno. I took promethazine daily 100-150mg a day for like 2 years with codeine/tram I dunno how I did it now.. maybe tolerance ..

 

[Jnowhere]

That's really strange. Its safer than benadryl which is otc. They give it out like candy in my area. (US, Texas)

Honestly there's no reason hydroxyzine shouldn't be OTC. Its safe, not addictive. I guess because its used more for anxiety than allergies they don't think it needs to be OTC.

I suggest you look into getting it imported if you really want some. I'm already veering awfully close to sourcing and I don't know the rules about legal substance sourcing, so I won't name names, but its pretty easy to find vendors for it from India, etc

What is it with certain drugs? Doctors are scared to prescribe, even though they will prescribe more addictive and potentially dangerous. I was on Ativan, which is stronger and a short acting benzo, but the weaker benzo used for getting off, of other benzos is an issue, diazepam, Valium. Morphine, Oxycodone, Ativan( lorazepam). I was given a year to live. I still don't know why doctors will prescribe stronger and more dangerous benzos and other drugs, but valium, scares them?

 

[KurtAurelius]

It depends what your looking for..

Synergic action, or deepening say the nod and euphoria.. but I’m of the opinion this is very hard to do in practice.

Caffeine seems to be decent for most but you mentioned it was eh..

THC ruins Opioids for me, just clouds the nice effects but may be indivual, I prefer CBD+CBG

(CBD+CBG would be my pick, these make my body feel very heavy and floaty)

Hyrdoxzine is the best shout for antihistamines IMO but other than anecdotally I am not aware if it’s better in a safety sense than promethazine or diphenhydramine (both imo pharmacologically nasty)

I’ve forgotten the name, but there’s the antihistamine that people went mental over in the UK, I can’t remeber but it was a formulation of either methadone, pethidine or dextromoramide and was unique in causing a noticeable difference, it began with a c maybe? Cylclizine?

But again perhaps not a safe suggestion.

Benzos etc, not safe.

Other than very high quality magnesium Threonate (crosses into the brain and id hazard a guess much better for tolerance), pre loading Agmatine or very low dose DXM (15-30mg) with abstinence for lowered tolerance I’m a bit stumped.

Theanine or a taurine -maybe? A little boost towards feeling relaxed.

As well as Lemon Balm, Passion Flower but can’t definitely say these are safe at all, but far safer than benzos.

Blue lotus may make a bit more of a mythical opium like experience but can’t say if safe.

 

[Keif' Richards]

@KurtAurelius you´re correct that the antihistamine in question would be known as Cyclizine. It was once prescribed with Methadone as a fairly common practice, as that is what people were doing out on the street.

Yes, I will say that a little bit of an antihistamine can be a nice, safe addition to a reasonable dosage of Morphine. I myself would enjoy 50mg Diphenhydramine (Benadryl) with some Morphine. I´m not positive wiy this is enjoyable. I have a theory that the sedation of the antihistmaines contributes to a kind of psychosomatic loop in which the increased sedation tells the person that they are getting higher. We all know how powerful the effect of placebo can be, so you can see why this might ea populat practice.

 

[TheLightBringer]

Hydroxyzine isnt that easy to get here. I couldnt even get it off the doctor i managed to get fucking dilaudid 4's and fentanyl patches off ffs. However the much inferior promethazine is otc. Doxylamine is also a good one. I personally hate benadryl

Strange, I always found promethazine to be more enjoyable than hydroxyzine as hydroxyzine made me more sluggish/gross feeling while promethazine seemed to synergize better with opiates. Propiomazine I also found to be pleasant with opiates even though it has slight D2 antagonism.
Honorable mention for high dose meclizine as it does get sedating in higher doses and is really good at eliminating nausea, also feels the least sluggish to me

 

[TheLightBringer]

My top 4 non-GABAergic suggestions would be:

Antihistamines

Low dose NMDA antagonists, DXM, Memantine

VGCC blockers (pregabalin, gabapentin, phenibut etc.)

Alpha-2 adrenergic agonists like clonidine or tizanidine (tread with caution)

Id be careful with VGCC blockers or A2 agonists as they are physically addictive as well

But these are some non-GABAergic options

 

[Keif' Richards]

For the record, yes, Hydroxyzine (Vistaril) would be my first choice. It just prodcues less peripheral side effects than Diphenhydramine (Benadryl) however, Hydroxyzine iw a prescription medication here in the states so it´s a lot less easy to access than Diphenhydramin which can be bought at any gas station or pahrmacy.

 

[notsmokeymcpot42088]

Antihistamines - Probably benadryl. Yes

White Grapefuit juice -- Maybe a little help

Benzos -- we are getting into synergy and 2 CNS depressants *yes Benadryl counts* starts to get a bit dangerous

So if I were you and still could experience an opiate high (SO JEALOUS) I would probably go with an OPI combo TBH

From your post I presume you haven't treaded into shooting yet --- if that is the case try a couple of Percocet with your morphine! High oral bioavailability -- kicks in way faster than morphine -- kind of best of both worlds!

For me I would do (After fentanyl ruined H at least) a shot of morphine mixed with dilaudid as the peak of opiate euphoria -- as the Dilaudid has an INCREDIBLE rush (Sucky oral or snorted % bioavailability and expensive though) and morphine is what heroin converts into fairly quickly.

I think a rapid acting (Which usually means short lasting) high oral bioavailability opiate is your best choice!!

** Oh yeah THC ** If you are a daily smoker -- hell I wouldn't even bother taking a "get high" dose of opi's if I didn't have a fair amount of pot to smoke with it......If you are a once or twice a week (or less) smoker idk YMMV .... but if it is a staple, that is what I would do 5 minutes after a shot or 45 minutes after a dose of opi's to "Really feel them"

 

[andrey]

Yeah, hydroxyzine will definitely contribute to a dreamy, sleepy feeling.
Personally I ended up with more hydroxyzine than I'll ever use because I went to a cheap online telehealth psychiatrist and told them I needed something for anxiety and panic attacks, that wasn't addictive. (I was coming off benzos but didn't want being an addict on my medical record so I didn't tell them that)
I only used it regularly for the first month, but I saw her 3 more times over a year to get more. I ended up with over 200 hydroxyzine pills that way. Most of these places are just pill farms trying to make money so they don't ask many questions. My appointments were sub 5 minutes after the initial consultation.

If you have insurance this is probably the cheapest way to get it. If not, its not a controlled substance so you can likely get it from certain online pharmacies.

To the mods: I'm sorry if this counts as sourcing talk. Since its not a controlled substance and I didn't give specifics like names, I'm not sure if it counts. Feel free to delete or edit this if it does.

Thanks for the tip bro, but I know where to look at lol.

Im not from the US, and I most likely have to pay for it, but that shouldnt be a problem. Im in OST, so I dont believe they would prescribe it to me. The only thing that is unfavorable with Hydroxizine is the extremely long half life. I have to be wary because of drug testing for OST, but I will look into it.

 

[andrey]

It depends what your looking for..

Synergic action, or deepening say the nod and euphoria.. but I’m of the opinion this is very hard to do in practice.

Caffeine seems to be decent for most but you mentioned it was eh..

THC ruins Opioids for me, just clouds the nice effects but may be indivual, I prefer CBD+CBG

(CBD+CBG would be my pick, these make my body feel very heavy and floaty)

Hyrdoxzine is the best shout for antihistamines IMO but other than anecdotally I am not aware if it’s better in a safety sense than promethazine or diphenhydramine (both imo pharmacologically nasty)

I’ve forgotten the name, but there’s the antihistamine that people went mental over in the UK, I can’t remeber but it was a formulation of either methadone, pethidine or dextromoramide and was unique in causing a noticeable difference, it began with a c maybe? Cylclizine?

But again perhaps not a safe suggestion.

Benzos etc, not safe.

Other than very high quality magnesium Threonate (crosses into the brain and id hazard a guess much better for tolerance), pre loading Agmatine or very low dose DXM (15-30mg) with abstinence for lowered tolerance I’m a bit stumped.

Theanine or a taurine -maybe? A little boost towards feeling relaxed.

As well as Lemon Balm, Passion Flower but can’t definitely say these are safe at all, but far safer than benzos.

Blue lotus may make a bit more of a mythical opium like experience but can’t say if safe.

Well, caffeine wasnt really bad. It kind off increased the euphoria, but it works against this dreamy warming feeling of morphine.
Regarding THC, and the other cannabinoids, I tried it but they also reduced the opioid effects. I loved smoking weed when I was younger, but I cant combine it with opioids nowadays, sadly.

I also tried most of the other herbal stuff and magnesium, taurine etc but they only influence the opioid feeling very mildly for me. I had the feeling that some of them where reducing the opioids effects, so I stay away from most of that stuff except for magnesium, agmantine or piperin. Blue lotus is something I actually havent heard of but it doesnt sound safe lol

The thing about anti histamines is a hit or miss. Some like promethazine or dimenhydrinat just create a horrible feeling for me. But this one called chlorphanamine was great. The only downside is that its only available with a bunch of other nasty substances and not on its own.

Allegedly the other alkaloids in the opioid extract seem to have a synergistic effect with the morphine, so if I get the opportunity I will try sourcing for them too.

 

[andrey]

Hydroxyzine isnt that easy to get here. I couldnt even get it off the doctor i managed to get fucking dilaudid 4's and fentanyl patches off ffs. However the much inferior promethazine is otc. Doxylamine is also a good one. I personally hate benadryl

Have you combining it with doxylamin?

Its pretty easy to get here. I tried it once for sleeping(before I was addicted to opioids) and I didnt really like the feeling then. Though, perhaps I can give it another try.

 

[paranoid android]

Have you combining it with doxylamin?

Its pretty easy to get here. I tried it once for sleeping(before I was addicted to opioids) and I didnt really like the feeling then. Though, perhaps I can give it another try.

Ya doxy is great here but kinda pricey. Only available in nyquil form here so its all brand name

 

[notsmokeymcpot42088]

You can get DXM cough strips that are just DXM HBR --- shite I forget the brand name but its something real common -- if not I know a place that sells 1g DXM 'energy drink' shots lmao -- (Just DXM) I can't just give you the source according to the rules but if you want message me I ain't planning to gain financially or anything lol (There is always grey in every rule book -- that is where you find me)

By the tone I take it you aren't really looking for other opi's/benzo's -- euphorian'ts to mix as much as potentiation of some kind --- you are on the correct path (as you know) promethazine (if you fancy) Benadryl (If you have no script and the same laws as me) -- DXM if you want (never played with it much except for w/d's) -- I still say opi-synergy would be your best bet but I got suggestions for whatever path you wanna go down lol

Caffeine is not recommended in general --- in w/d it can really hurt --- when high, it isn't gunna keep you awake when you want it to. YMMV of course

 

[paranoid android]

You can get DXM cough strips that are just DXM HBR --- shite I forget the brand name but its something real common -- if not I know a place that sells 1g DXM 'energy drink' shots lmao -- (Just DXM) I can't just give you the source according to the rules but if you want message me I ain't planning to gain financially or anything lol (There is always grey in every rule book -- that is where you find me)

By the tone I take it you aren't really looking for other opi's/benzo's -- euphorian'ts to mix as much as potentiation of some kind --- you are on the correct path (as you know) promethazine (if you fancy) Benadryl (If you have no script and the same laws as me) -- DXM if you want (never played with it much except for w/d's) -- I still say opi-synergy would be your best bet but I got suggestions for whatever path you wanna go down lol

Caffeine is not recommended in general --- in w/d it can really hurt --- when high, it isn't gunna keep you awake when you want it to. YMMV of course

DXM never boosted opiates for me. I would only mi the 2 when i had a bad flu or something.

I actually like caffeine with morphine. Nothing like a shot of morphine with some coffee and a sativa to wake you up