Schizophrenia

[Them Witches]

ER diagnosis :


"Transient ambience" refers to a short-lived, temporary atmosphere or feeling, where the word "transient" describes something that is fleeting, passing, or constantly changing. The "ambience" is the quality or feeling of a place, situation, or experience. Thus, a transient ambience would be a temporary mood or characteristic that doesn't last long, like the changing atmosphere of a festival or the passing mood of a life moment. schizophrenia cannot get past this. it stays stuck for days, seasons, etc.

A shattered mind in pieces that cannot heal easily.

 

[4DQSAR]

Well, I'm always happier when a researcher begins with 'this is our current best understanding' rather than stating something as fact.

When I first took an interest in this disorder 40 years ago, we knew even less so it's great to see people are still piecing together this complicated disorder.

I think the first paper that really interested me was one that noted that patients with schizophrenia had elevated levels of DOPAC (a dopamine metabolite) and/or reduced levels of NMDA in their cerebrospinal fluid. Around 90% had elevated DOPAC which is why I assume dopamine antagonists are so well represented in the medications available. But I was more interested to know about those who only had reduced NMDA. Turns out that at the time they were referred to as 'refractive' to medication... which makes sense if their dopamine levels are normal.

So my first hypothesis was that we may actually be witness to two disorders that present in the same ways.

I was excited when researchers developed NMDA modulators but when trialled, it only showed significant improvements in around 10% of patients. I had assumed that they expected this but further research was cancelled. I suspect from a business standpoint, a medication that could at best only get a 10% market share wasn't deemed worth the cost.

Thanks.

 

[Them Witches]

@4DQSAR

During my childhood at 7 I was plagued with chronic migraines and cluster headaches and they lasted til age 22. Growing up I had a lot of explosive energy and need to release that rush of feelings. MY grandparents were concerned about me throughout my childhood and into the late teens. They said I did not smile much and have a lack of facial expressions unless I was manic in behavior & physical action. I turned to bike riding, skateboarding, sports, base jumping, fighting (anything that consisted of adrenaline or an instant gratification away from feelings). At age 7 I was taking 60mg of Codeine almost daily. By age 12, I was on Hydrocodone and Morphine. Which lead to drinking and weed at 12 and that did not do any favors. My reality was very distorted but I was lucky to have a dozen (12qty) skateboard friends. They helped my stay in line and loved me unconditionally. It was like I had a service dogs as friends for when my brain would get too far out there.

In my early 20's the mental illness really reeled it's ugly head. I was on Invega, Seroquel, Risperidone, and Xanax. I have been on Haldol, Olanzapine, and others. I took them for a decade and decided to stop taking them. I felt the meds did all they could do and the rest was up to me. I stopped taking them and learned how to deal with the mental illness on my own didn't matter how long it would take. Once degenerative bone disease started I started getting on a bunch of meds. I stayed strong for awhile then the I had life triggers that induced the mental illness full-strength. Since I was a kid I was obsessed with death and would hold my breathe all the time until I passed out or I would give up and breathe. When I hit age 20, hallucinations began and paranoid & delusional thinking told hold. It has progressed until now.

I am seeking help. I started Zoloft 5 months ago and Busbar now for 2 months. They are helping but the hallucinations have not gotten better. I just ride with it and do my best. The only psych med I would want to take is Haldol for that. Having chronic pain syndrome and mental illness sucks and I do not wish it on anyone. I have a SNS disorder were my brain stays in "fight and flight mode". If I get mad my BP/Pu hits 190 over 130 Pu 170-185bpm instantly. Pain increases it, stress does, and sex does it too. Doctor says I am not wired right and I am is only patient like this. Actually at the whole practice. They call me the "whole patient."