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Schizandrol A mechanism of action?

lenses

lenses

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Schizandrol A (a common synonym is deoxyschizandrin) is a chemical extracted from the schizandra berry , and I can't seem to track down any relavant information as to its receptor afffinitys or any real mechanism of action, the information is quite conflicting.

From what I gather from experience, schizandrol a is moderately empathogenic, estrogenic , and quite very possibly an MAOI , and quite possibly inhibitory. It is quite pleasant to dose 200 mgs, I wouldn't go so far as to say it is "MDMA-like" , but it is somewhere in the loved up spectrum.There is no comedown, nothing like that. Seems to have some sort of potentiating effect of psychedelics.

With the broad ranging tonic effects it seems to point to MAOI effects with some nootropic-esque choline turnover promoting activity.

Does anyone have experience with schizandriol a ?

-lenses
 
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http://www.ncbi.nlm.nih.gov/pubmed/1678991
In the neurotransmitter studies, significant elevations of dopamine and its metabolite DOPAC (in striatum) and DA (in hypothalamus) were observed after i.p. administration of 50 mg/kg or 100 mg/kg of schizandrol A. But the receptor binding experiments showed that schizandrol A had no affinity for dopamine D1 and D2 receptors, serotonin receptors and alpha 1-,alpha 2-adrenergic receptors, and it did not affect the binding of dopamine to dopamine D1 or D2 receptors. These results indicate that the inhibition exerted by schizandrol A on the CNS may be related to the dopamine system, and the increase of dopamine turnover has nothing to do with dopamine receptors. The concentrations of the norepinephrine metabolite MHPG and the serotonin metabolite 5-HIAA showed changes in rat striatum and hypothalamus after schizandrol A treatment, but norepinephrine and serotonin levels were unaffected.
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Maybe some 2ndary dopamine releasing effect (NMDA???), I don't think it's a DRI or MAOI.

It may involve Na channels or nitric oxide
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159731/
All available results have demonstrated that schisandrin produced NANC relaxation on the rat colon, with the involvement of NO and acting via cGMP-dependent pathways. ATP, but not adenosine and VIP, likely plays a role in the non-nitrergic, apamin-sensitive component of the response.
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Oh thank you sekio! That is the most relevant information i've been able to find, period . I need to figure out the pubmed login for my school. :)

Kind of unique mechanism of action ey?What a weird weird crab looking molecule!

I wonder if that colon relaxation effect is helpful with diarrea from withdrawls? I successfully kicked suboxone with a chinese herbal formula called "xuan xui" or "weinicom" and schizandra was one of the top 3 ingredients . Taking isolated schizadriol a helped a lot ! Perhaps you are onto something with the NMDA part of the picture - I tend to reallllllly like anything NMDA modulating , perhaps that is how it helps withdrawls.

Schizandrins are amazing from the liver from what I read (and experience),it seems to clear up the whites of the eyes which is a good sign. Good stuff. Good stuff.

-lenses
 
I dunno, I could see that binding to the dopamine transporter and plugging it up.
 
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