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Salvinorin

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Stbernard808

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Jan 11, 2005
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Salvinorin C is said to have much different affects on the body and mind that salvinorin A. i was wondering if anyone can back this up with personal experiance
 
wikipedia said:
Salvinorin A is one of several structurally related salvinorins. Salvinorin A can be synthesized from the inactive salvinorin B by acetylation. The des-acetylated analog salvinorin B is devoid of human activity. It was speculated that salvinorin C might be even more potent than salvinorin A, but human tests and receptor binding assays could not confirm this. Salvinorin A seems to be the only active naturally occurring salvinorin
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I don't really know that much about it actually...maybe this helps...
 
thankyou for trying for me. that was actually the paragraph i read that made me want to post a question here.
 
From Daniel Siebert's most recent paper: "Receptor assays of salvinorin C are in progress. Preliminary results suggest that it might be weakly active at kappa-opioid receptors, but certainly much less active than salvinorin A, and possibly inactive (B. L. Roth and T. A. Munro, pers. comm.). Self-experiments performed by the author indicate that salvinorin C is not psychoactive."

There may also be something for you hidden in here...I dunno...I'm feeling really lazy right now so I didn't read it...
 
thankyou very very much. those articles are pretty interesting reads, i just skimmed over them.

you might want to look at the second one more closely sometime later if your interested.
 
The second one describes only the synthesis, not the pharmacological data like binding affinities and the like.
 
Theres a salvia extract sold here in Australia that doesnt really give the4 full effects of the old salvia leafs or extracts but has a very downer effect and its often mixed in as "sage" into smoking blends. Forget which Salvia plant it is but its totally legal here, as Salvia was banned around 2001-2002 here.
 
Thats the one. They mix it with a bit of divinorum I believe just to get some psycdhedelic/dissociative effects, other than that a big pipe of 5x does S.F.A and the normal salvia leaf used to flog me after 3-4 bong loads and holding it in
 
Salvia splendens contains the same salvinorins that are in S. divinorum I believe, just at such low concentrations that you can't really get wasted off it (except maybe if you had a real strong extract). But anyway you would expect to get normal salvia effects off S. splendens if you managed to take enough to get high.

Salvia miltiorrhiza is another plant from the sage family that is active, doesn't contain salvinorins though, instead it has a compound called miltirone which is a GABA-A partial agonist. So if theres an ingredient labelled as "sage" which has a downer effect it could well be S. miltiorrhiza.
 
I wonder if they've tried replacing the acetyl group (the one that makes the difference between salvinorin A & C) with an amino acid residue (glycine being the obvious candidate as it can also be called 2-aminoacetic acid) in order to attempt to create a water soluble, active compound?
 
mad_scientist said:
Salvia splendens contains the same salvinorins that are in S. divinorum I believe, just at such low concentrations that you can't really get wasted off it (except maybe if you had a real strong extract). But anyway you would expect to get normal salvia effects off S. splendens if you managed to take enough to get high.

Salvia miltiorrhiza is another plant from the sage family that is active, doesn't contain salvinorins though, instead it has a compound called miltirone which is a GABA-A partial agonist. So if theres an ingredient labelled as "sage" which has a downer effect it could well be S. miltiorrhiza.
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Strange you mention this GABA agonist, I don't know if this would have anytihng to do with it, but after smoking what we thought was an extract of mostly Splendes mixed with some Divinorum, my friend was on 2.5mls of pure GBL, then had a 1ml re-dose an hour or less after, then we s moked this and he was going schizo.. Doing the whole G overdose thing (and he can normally handle this dose.. and snaps out of anything weird after not too long), but much, much worse. It lasted for hours and he was totally out of control, flailing around in public in his car beeping the horn, trying to walk out and running into people, nearly fell on a baby stroller/pram. Then tried to get into the pasenger seat of a car that he thought was his (which was a stationwagon and his car is a sedan and a different colour...)
 
Not knowing what the S. divinorum content was, that's hard to answer. Definitely sounds like Salvia, but only sorta.

Think it's possible that with GABA receptors occupied, it might have had some effect on the KOR?
 
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