Salidrosides dopaminergic, Rosavins serotinergic

[Chemgineer]

Just as an anectdotal FYI, from my own bioassays of Rhodiola, it is the salidrosides that provide the dopaminergic effects. Upon my first taking a rhodolia product, I was impressed by the effects. I was struck by the distinctly dual action it had. There was a pronounced dopaminergic feel, as well as a pretty strong serotinergic feel.
(I think we can all agree that its possible to generally discern between the two, and this kind of determination can be made. )
Most Rhodiola products contain 3% roasivins and 1% salidrosides, standardized. The reading i did on the web led me to believe that the rosavins were the chemicals responsible for the positive effects. (for me the positive effects would be the dopaminergic ones)

I purchased a product that claimed to contain only rosavins, its labeling discounting the role of the salidrosides in the effect. Well this product produced a strong and pronounced serotinergtic effect. No dopaminergic effect at all.

In Nature, the plant has about 5% rosavins to 1% salidrosides.

A product I found today had 1% of the rosavins and 1 % of the salidrosides.

Upon taking a few doses of this, It was evident that there was very little of that serotinergic feel and all of the dopaminergic shone through nicely.

I deduced from all this that salidrosides may be a likely canidate for the dopaminergic, stimulatory effect of Rhodiola. The sedative , droopy eyed, serotinergic effct that some rhodiola products produce I believe are due to the rosavins. The higher the rosavins, the more serotinergic it felt.

The product that was only rosavins made me feel like I took a paxil, pretty nasty...

 

[onmyway]

would you say that it was an enjoyable experience?

The only straight up dopaminergic that ive messed with is ritalin, and i was kinda disappointed by it.

 

[wungchow]

can we please get some references and chemical structures?

 

[etnik]

Just as an anectdotal FYI, from my own bioassays of Rhodiola, it is the salidrosides that provide the dopaminergic effects. Upon my first taking a rhodolia product, I was impressed by the effects. I was struck by the distinctly dual action it had. There was a pronounced dopaminergic feel, as well as a pretty strong serotinergic feel.
(I think we can all agree that its possible to generally discern between the two, and this kind of determination can be made. )
Most Rhodiola products contain 3% roasivins and 1% salidrosides, standardized. The reading i did on the web led me to believe that the rosavins were the chemicals responsible for the positive effects. (for me the positive effects would be the dopaminergic ones)

I purchased a product that claimed to contain only rosavins, its labeling discounting the role of the salidrosides in the effect. Well this product produced a strong and pronounced serotinergtic effect. No dopaminergic effect at all.

In Nature, the plant has about 5% rosavins to 1% salidrosides.

A product I found today had 1% of the rosavins and 1 % of the salidrosides.

Upon taking a few doses of this, It was evident that there was very little of that serotinergic feel and all of the dopaminergic shone through nicely.

I deduced from all this that salidrosides may be a likely canidate for the dopaminergic, stimulatory effect of Rhodiola. The sedative , droopy eyed, serotinergic effct that some rhodiola products produce I believe are due to the rosavins. The higher the rosavins, the more serotinergic it felt.

The product that was only rosavins made me feel like I took a paxil, pretty nasty...

I share you experience, or at least I have good indications, that it may work the same on me. I first bought a chinese rhodiola, standardized to salidrosides. These pills really lighted me up, mentally, seem to bring also more muscle strength, more locomotion, perhaps also a little irritability. I read you should buy the russian root because of its rosavin content, so I bought one primarily high in rosavins no report on salidrosides. Contrary to my expectations, although it lifted mood at first, it made me feel relaxed and even fatigued. It is now the third day that I am on it and this effect seems not to change. It certainly reduces stress and I like the relaxed feeling, but I don't know whether it also will sharpen me cognitively or physically. Physically certainly, I have not the urge to run around like I had so pronounced on the chinese rhodiola. The fatigue is a little less today, perhaps it also relaxes the body enough to sleep well and feel more rested in the long run. This may be as important is the stimulant properties.

 

[Phener]

rhodiola was one of my favorites but dosing was just too expensive.

I always felt it had a stabilising effect, admittedly this could be from the serotongic effect HOWEVER I always predicted it had some kind of partial-agonist/anatagonist effect on dopamine.

Would be very interested to know the effects salidroside pure. That is if it's bioavailibility isn't dependant on other chemicals contained

 

[etnik]

rhodiola was one of my favorites but dosing was just too expensive.

I always felt it had a stabilising effect, admittedly this could be from the serotongic effect HOWEVER I always predicted it had some kind of partial-agonist/anatagonist effect on dopamine.

Would be very interested to know the effects salidroside pure. That is if it's bioavailibility isn't dependant on other chemicals contained

I don't think rhodiola is very expensive compared to other supplements, certainly not when buying from American sites. Anyway I have found the chinese rhodiola to be cheaper. If you are looking for more salidrosides then rosavins, or even no rosavins at all, you should look for chinese rhodiola. They always advice not to buy chinese rhodiola on the basis of the fact that they do not contain rosavins, only salidrosides, and hence are not effective. I disagree, the chinese herb does have a profound stimulating effect. The rosavins may indeed be more stabilizing, but it not necessarily seem to make you sharper.