I've been doing a little research into saffron and it seems that the effects from it are highly unlikely to be placebo. Most people seem to report mild euphoria, and a resemblance to a low dose of MDMA or methylone.
I'm just wondering what causes this? A thread over on shaman-australis forums (here) mentions that safranal is probably the cause, but there doesn't seem to be anything to compare it to structurally.
There are also studies on pubmed (1, 2 and 3) stating that saffron's antidepressant effects are more than placebo. Also a thread on entheogen.com (here) talks about saffron's effects, along with a thread here - on bluelight.
So what causes this? I've looked at the structures of safranal, crocetin, crocin, safranal and picrocrocin, and the only thing I can really think of is that maybe crocin goes under some sort of reaction (in vivo) that froms it into trans-4-hydroxy-crotonic acid (or a similar looking GHB analog).
I've attached an image below to make things a tiny bit clearer.
(http://www.bluelight.ru/gallery/showphoto.php?photo=38140&cat=621)
ALSO: if anybody could find me the full article for this: http://www.ncbi.nlm.nih.gov/entrez/...ve&db=PubMed&list_uids=10815004&dopt=Abstract it would be appreciated
I'm just wondering what causes this? A thread over on shaman-australis forums (here) mentions that safranal is probably the cause, but there doesn't seem to be anything to compare it to structurally.
There are also studies on pubmed (1, 2 and 3) stating that saffron's antidepressant effects are more than placebo. Also a thread on entheogen.com (here) talks about saffron's effects, along with a thread here - on bluelight.
So what causes this? I've looked at the structures of safranal, crocetin, crocin, safranal and picrocrocin, and the only thing I can really think of is that maybe crocin goes under some sort of reaction (in vivo) that froms it into trans-4-hydroxy-crotonic acid (or a similar looking GHB analog).
I've attached an image below to make things a tiny bit clearer.
(http://www.bluelight.ru/gallery/showphoto.php?photo=38140&cat=621)
ALSO: if anybody could find me the full article for this: http://www.ncbi.nlm.nih.gov/entrez/...ve&db=PubMed&list_uids=10815004&dopt=Abstract it would be appreciated
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