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Safety of gamma-amino-beta-hydroxy-butyric acid compared to other Ghb analogs.

egor

egor

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I have been able to find a whealth of info on 1,4 butendoil, gvl, and other more well known analogs, but the info on gamma-amino-beta-hydroxy-butyric acid is very sparse from the sources I have to work with. There are 2 reports on erowid, but my other sources are much less helpful. Any info would be appreciated.
 
uh, its safe enough and realtively poor if you are looking for a GHB substitute

as it acts on GABA-A it does not share the effects of GHB which occur on GHB and GABA-B receptors
 
The location of the hydroxy group is gonna be awfully important; I can't imagine the beta-hydroxy would be much good.

I can't find them on erowid, do you have a link? Is it under a different term??
 
Really? I have always wondered about GABOB (beta-hydroxyl-GABA). If anything, it makes sense that it would affect both GABA-A and GABA-B receptors, due to its close structural homology with GABA. It does have a real effect--I have taken it and it is a relatively effective anxiolytic without a sedative effect at a dose of 1g. Another pet theory I have about GABOB is that it binds to the a2d auxiliary subunit of the N-type Ca++ channel, like gabapentin and pregabalin. Like those two, GABOB has a stereospecific anticonvulsant effect, with the (S) enantiomer being 2x the potency.
 
Also, you can check Wikipedia for some info about GABOB, though personally I dont think it has potential for a GHB substitute, if any at all.
 
I'm looking for something to take the edge off of mild back spasms, not something to get thrashed on.
 
Refluxer said:
Isn't there a butene with similar characteristics to GHB?
Click to expand...

There is, with a stronger effect to GHB according to its rigidity of double-bond. It is trans-4-hydroxycrotonic acid or trans-4-hydroxy-2-butenoic acid.
 
Sort of related...
I've seen two refs stating that gbl-g-COOH and succinic acid and its salts (along with ghb, gbl, 1,4-bdo, etc) possess "anesthetic activity" and modulate dopamine levels. I think I remember succinic acid's LD50 being lower than GHB's, and it being a possible carcinogen. It plays a part in cellular respiration, so I'm not really sure what to make of it all. Any comments?
 
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