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Safety of DMSO

Nexus298

Nexus298

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682536/?tool=pmcentrez

Claims that DMSO causes apoptosis. I was under the impression that DMSO is used in many creams and topical drugs for it's cell penetrating effects. I have heard of people using DMSO as a means of delivery of nutrients to cactus. My question is are these cacti now insufficient as ethnobotanicals after the use of DMSO? Before this study I had regarded DMSO as relatively safe. any comments from the brilliant minds here?
 
DMSO, I dont really know that much about it except you can't legally buy it in the US. except for like vet professions. Or you could get it online. I think some people use it for joint pain, I know someone who used to be in the NHL used it for this.

I am also interested in possible uses of drug administration for this product

I don't think it is safe though because of its penetrating effects you cannot touch it with your hand in administration, or at least that's what mine says on the bottle
 
I've thought about using it for suboxone administration.

Anyway- causing apoptosis isn't necessarily a bad thing. Preventing apoptosis is.

THC increases apoptosis, which I've suggested is probably at least partly the reason why they have such a hard time connecting cancer to even high dose, high frequency cannabis smoking.
 
pussywillow said:
DMSO, I dont really know that much about it except you can't legally buy it in the US. except for like vet professions. Or you could get it online.
Click to expand...

What do you mean by this? You mean its not commonly available over-the-counter? Because its sure widely available on the 'net, and almost all companies are willing to ship to the US. Some big names carrying it, too.
 
Hammilton said:
I've thought about using it for suboxone administration.

Anyway- causing apoptosis isn't necessarily a bad thing. Preventing apoptosis is.

THC increases apoptosis, which I've suggested is probably at least partly the reason why they have such a hard time connecting cancer to even high dose, high frequency cannabis smoking.
Click to expand...

...whereas nicotine inhibits apoptosis.
 
I work in a chemistry lab and we use DMSO for a variety of applications, but it is mainly used as a selective solvent. It is in no way reserved for veterinarians, in fact, almost anyone can obtain this chemical... I have no idea how the hell someone came up with that. Anyways, one of the major concerns with using DMSO in the lab is the fact that, as previously noted, it penetrates the dermis while "carrying" with it all the chemicals it has solvated. As you could guess, if you are working with organo-mercury compounds or something like that you must be VERY careful as to not spill on oneself. DMSO will go through latex, epidermis, and subcutaneous fat, delivering whatever chemicals are in it.

So, to answer the question of its potential for drug delivery, I would say the efficacy of DMSO would be unrivaled. As long as your DOC is soluble in DMSO, I would predict that application to the skin would be highly effective.
 
With the lower alkylmercury compounds at least, they don't NEED to be dissolved in DMSO to skullfuck you a new CNS, look up the wiki for dimethylmercury and see just how damned nasty that stuff is. As little as 100microliters has been cited as fatal, via skin contact, and that was with somebody working with it, who spilled a couple of drops onto their gloves.

(2CH3)(Hg) goes straight through most gloves, including latex, butyl rubber and neoprene, and apparently does it pretty damn quickly, the person in the incident in question took the gloves straight off, resulting in neurological dysfunction at 5 months post incident, death in ten months.

It is one of a list of a few things I just will not work with, along with elemental fluorine, HCN(unless generated in situ/piped straight into where its meant to be going from the source), most organic peroxides and ClF3. Short of some of the toxins from pathogenic bacteria, batrachotoxin, some of the dinoflagellate polyketide toxins such as palytoxin and maitotoxin, and some of those cytotoxic proteins such as diamphotoxin or abrin, organomercurials are about as evil as toxins get. Worse possibly, due to how insidious and slowly acting it is. Apparently, the first two people to synthesize the compound, died also.
 
yeah sorry about that, I actually did some reading and it's not illegal in the US. I think that whoever gave me that information may have thought that it was only accessible to vets because it is greatly used in vet professions such as horses etc.
 
I have heard reports of people ingesting DMSO either as some sort of wacky nutritional supplement or as a salve for arthritis/joint pain with no apparent ill effects. I see no good reason to go about ingesting it but as DMSO is likely to be formed in your body by sulfide metabolism I don't think there's much to worry about.
 
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