Misc Safe methadone dose, lisdexamphetamine, and nicotine.

[#Intothemdrugs]

I want to start off by saying i have no tolerance to either methadone or vyvanse (lisdexamphetamine). I love both these drugs and was wondering if it would be safe to combine them. I was planning on taking 20mg methadone (only usually do 10mg, gets me high enough, and i only did it two days in a row and that was 3 days ago. before that i havent touched opioids since spring break) and 150mg vyvanse (my normal abusive dose. I take 30mg daily but havent for about a week). Would it be safe to do these doses, and also to combine cigarettes? I was wondering if the maoi in tobacco would give me problems, or if i would be safe at these doses. The most methadone ive done at one time is 15 mg, and the most vyvanse ive done at one time was either 210 or 240mg (I used to use a lot, but not recently), but i wanted to make sure combining these was somewhere near safe.

 

[Crashing]

I would recommend taking normal dosages of both. I personally would do 10mg methadone and 70mg of vyvanse but if you're used to 150mg vyvanse then you will be fine. They will compliment each other nicely, no need to go to 20mg on methadone. That will just ramp your tolerance quicker.

And the nicotine will improve and lengthen the effects of each without adverse reaction, but i suggest getting nicotine from something other than tobacco, cause tobacco is horrific.

 

[Keif' Richards]

First off, consuming cigarettes isn't going to have any kind of appreciable effects on your body's response to a given substance, at least in terms of immediate safety. Smoke away, you just have to worry about the well-known chronic damage that tar and nictotine cause to your body.

Now, Methadone. It sounds like you have a pretty decent handle on how much of this drug you can handle in a sitting. A conservative estimate for an opiate naive individual is going to top out at ~30mg. In reality, people often consume higher dosages, especially while under the influence of amphetamines. This is an HR site, so I think you've got the right idea on your dosage, and in my lay-person opinion, you aren't taking any unneccesary risks.

I assume you have some basic knowledge regarding Methadone's half-life. Considering you are on BL and have internet it would be a shame to be without it. Methadone is probably the longest active opiate/oid that you're going to encounter on a regular basis here in North America. It will build up in your body in a way that say, Oxycodone or Brown will not. Dosing over multiple days could cause an unexpected build up. Methadone sneaks up on you in terms of sedation. Even when you think you know it well, it can have you in zombie-mode. Again, though, you're being pretty responsible with the dosages, it's just good to be aware of what COULD happen.

Don't be tempted to take more methadone than you normally would just because you're on the speed. The half-lives are too unpredictable, especially with the LisDex, you could feel like a champ because the speed has you "up", but the methadone could easily knock you out once the speed wears off. Just be careful and use common sense

 

[#Intothemdrugs]

Yea I got you guys. Tolerance doesn't isn't really worrying me as I don't have a steady supply of opioids, and it does go down after a while. About the half life, it seems like for me the euphoria goes away after 7 hours I don't know if in a good metabolizer or I just get desensitized or what, but I figure that adding the 10mg won't push euphoria and potentially dangerous effects over 15 hours, which is how long the high and comedown of lisdexamphetamine (or at least until I can sleep) lasts. I also don't regularly use cigarettes, but my vape pen is on the fritz and I'm waiting for a new one. Plus cigarettes feel much better than vapor pens when speeding. It might be because of the maoi, more nicotine, or the additives I don't know, but it does.

 

[rhun]

A little confused by your first post, you state that you have no tolerance but have done both drugs several times before? Sounds like you have a low tolerance but have experimented with both drugs previously (just not together), is that correct? Just wanting to clarify.

I wouldn't expect methadone + vyvanse to be anything special, tbh. But you can definitely dose them together and you may really enjoy the combination. I'm not worried about the vyvanse, especially because you take it daily. Methadone, however, can be really dangerous for opioid naive individuals due to its potency and long duration. Many people have gotten into trouble by taking one dose of methadone then redosing because they didn't feel it only to have the first dose kick in. Or, people have done depressants the next day after doing methadone, not realizing it was still in their system. So just be aware of how to safely use methadone.

Became this will be your first time combining them, I would dose the vyvanse first and wait for it to kick in before dosing the methadone. I think your regular dosage should be safe, but you can reduce it to 100mg if you want to err on the side of caution. By dosing it first, you'll be aware of which effects are from which drug instead of them blending together and the methadone will help with the come down. To be on the safe side with the methadone, I'd dose 10mg at once.... then dose 5mg more if it's not enough, but wait 4-6 hours to redose.

I wouldn't go over the max doses you've previously used, even though the vyvanse may counteract some of the methadone's effects. You can dose them together at the same time next time if you want, but honestly I think you'll find that downers are better for the come down anyway. You don't have to worry about insomnia, anxiety, restlessness, etc.

 

[#Intothemdrugs]

Thank you for the responses. I dosed the lisdex at around 6:20 at 150mg, and the methadone at around 7:30 at 20mg. It was kind of a waste for me, I felt like I was having all the negative side effects of amps and none of the good :c oh well. Good news is I'm not dead I suppose.