plumbus-nine
Bluelighter
I've been attracted by MDMA for a long time but somehow because I'm prone to anxiety and depression never came to actually try it yet. Well as pharmacology helped me to kick morphine, I've been thinking about what we have to offer against empathogen rebound.
The primary origin will be a) serotonin and to a lesser extent dopamine depletion and b) neurotoxicity. The latter is probably mostly caused by dopamine's tendency to oxidate, thus causing free radicals which when occur at a concentration too high, will cause damage which (hopefully) will be repaired over some time.
Now for both there's a solution:
- 5-hydroxytryptophan circumvents the rate limiting step in serotonin production, so in theory should allow an immediate restock of precious 5-HT. Problem is that most of it gets metabolized in the gut, where it's useless and only produces nausea, thus limiting the amount one can/will take. Solution would be to combine with a peripheral carboxylase inhibitor like carbidopa. These are used to avoid the same problem with pharmaceutical levodopa. I failed to source it in pure form but when it's not for antidepressive but post-roll use one might actually want to consider L-DOPA as well, just for the case dopamine should be depleted as well.
- Harm reduction organizations and smartshops dispend vitamine pills, specially Vitamin C as an antioxidant - that's the right intent but doesn't work as long as one isn't depleted. Thanks to our Russian friends we have emoxypine though which when taken plenty enough (125mg every 4-6h, dunno but doubt that a slight excess'd be that dangerous) is able to limit/alleviate dopamine oxidation. It has been shown to raise dopamine levels (because less of it gets broken down) and in an experiment it got rid of the methylphenidate rebound almost completely.
- What seems to be relevant specially against tooth grinding and muscle aches is magnesium. Here, again, what's often sold doesn't work quite right. We have an abundancy of different Mg forms and salts and not all of them are really bioavailable. This MIGHT be possible to switch/stack with a NMDA antagonist like memantine. I read from times to times that people use some ketamine to 'land' softly, which sounds entirely possible to me as they do the same with stimulants.
- Other, quite dangerous, attempt would involve low doses of a MAO-inhibitor, maybe a reversible one, AFTER the peak (using the right tool one might even get rid of up-peak-down). Inspired by 4,4'-dimethylaminorex, which when used in low dosage (25mg/d) gave me the maybe best two weeks in my life, it's ''crash'' was limited to a 5 min or so period of strong sadness but that was it. For 10+ days, every day again. As I got a strong hangover though from the first ~50mg I didn't dose higher but I suspect its MAOI properties to be very low to possibly insignificant besides toxicity with mixed use (well, it's gone anyways because of said toxicity and fatalities, sadly), I'm unsure but as it doesn't seem to be possible to use MDMA this way, in low dosages daily, the substance was special and I'd love to recreate this. Again, very dangerous, don't do it without an accurate mg scale and RIGID titration rules.
- Don't drink alcohol, it's horrendously toxic. People tend to drinkbining all possible substances because it's legal but it might easily be the most toxic psychoactive (not including overdoses) currently sold legally. It's ridiculous.
What do you think, is it possible to roll, maybe even 'too often' and getting away with it? Few people believe that you can actually skip opioid withdrawal but it's proven to work.
The primary origin will be a) serotonin and to a lesser extent dopamine depletion and b) neurotoxicity. The latter is probably mostly caused by dopamine's tendency to oxidate, thus causing free radicals which when occur at a concentration too high, will cause damage which (hopefully) will be repaired over some time.
Now for both there's a solution:
- 5-hydroxytryptophan circumvents the rate limiting step in serotonin production, so in theory should allow an immediate restock of precious 5-HT. Problem is that most of it gets metabolized in the gut, where it's useless and only produces nausea, thus limiting the amount one can/will take. Solution would be to combine with a peripheral carboxylase inhibitor like carbidopa. These are used to avoid the same problem with pharmaceutical levodopa. I failed to source it in pure form but when it's not for antidepressive but post-roll use one might actually want to consider L-DOPA as well, just for the case dopamine should be depleted as well.
- Harm reduction organizations and smartshops dispend vitamine pills, specially Vitamin C as an antioxidant - that's the right intent but doesn't work as long as one isn't depleted. Thanks to our Russian friends we have emoxypine though which when taken plenty enough (125mg every 4-6h, dunno but doubt that a slight excess'd be that dangerous) is able to limit/alleviate dopamine oxidation. It has been shown to raise dopamine levels (because less of it gets broken down) and in an experiment it got rid of the methylphenidate rebound almost completely.
- What seems to be relevant specially against tooth grinding and muscle aches is magnesium. Here, again, what's often sold doesn't work quite right. We have an abundancy of different Mg forms and salts and not all of them are really bioavailable. This MIGHT be possible to switch/stack with a NMDA antagonist like memantine. I read from times to times that people use some ketamine to 'land' softly, which sounds entirely possible to me as they do the same with stimulants.
- Other, quite dangerous, attempt would involve low doses of a MAO-inhibitor, maybe a reversible one, AFTER the peak (using the right tool one might even get rid of up-peak-down). Inspired by 4,4'-dimethylaminorex, which when used in low dosage (25mg/d) gave me the maybe best two weeks in my life, it's ''crash'' was limited to a 5 min or so period of strong sadness but that was it. For 10+ days, every day again. As I got a strong hangover though from the first ~50mg I didn't dose higher but I suspect its MAOI properties to be very low to possibly insignificant besides toxicity with mixed use (well, it's gone anyways because of said toxicity and fatalities, sadly), I'm unsure but as it doesn't seem to be possible to use MDMA this way, in low dosages daily, the substance was special and I'd love to recreate this. Again, very dangerous, don't do it without an accurate mg scale and RIGID titration rules.
- Don't drink alcohol, it's horrendously toxic. People tend to drinkbining all possible substances because it's legal but it might easily be the most toxic psychoactive (not including overdoses) currently sold legally. It's ridiculous.
What do you think, is it possible to roll, maybe even 'too often' and getting away with it? Few people believe that you can actually skip opioid withdrawal but it's proven to work.
