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Stimulants Ritalin versus Vyvanse versus dextroamphetamine (dexedrine)?

JohnBoy2000

JohnBoy2000

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Joined
May 11, 2016
Messages
2,596
I used to response to noradrenaline boosters.

Now they actually make me slow and tired.

I do however now respond to dopamine boosters.

Doctor has prescribed me 20 mg ritalin to be taken as needed. It's actually okay, but using everyday may make it less efficacious?
Possibly.

Where I'm at, lisdexamphetamine is available, but in terms of stimulating dopamine activity, I'm unsure how it compares to regular dexedrine?

I would go for dextroamphetamine ahead of the other mixtures with levoamphetamine, as I understand now I respond to pure DA enhancement with noradrenaline enhancement, and actually wish to avoid the latter.

Those who have used both or all three?

How would you compare them in terms of affect?

Increasing DA boosts motivation and focus I guess?
That's what I need right now.
 
Last edited:
Methamphetamine could be a consideration?

But I really don't need serotonin or noradrenaline enhancement.

I understand meth boosts all three equally?

Plus it has a bad reputation (but not as bad as non-pharma grade amphetamine which is apparently all sorts of crap, and getting dextroamphetamine "speed" is probably impossible).
 
Ime Phenidates don t work while they are potent Dopamin boosters.

dl-Amphetamine, which is top knotch here. Its an ok booster but two problems its powder.
snortmania lurin. And when going oral measurment required. But then all in all its euphoric.
Which kinda distracts from the purpose, focus.
And its probably partly the Noradrenaline as well as more PNS activity.

So for the purpose dextro-Amphetamine imo seem the best less Nor-Adrenaline less PNS.
No experience with the Lis- form. Ir dex is for me like slow release, maybe because i started on Methylphenidate.
Could sleep on it, before i got insomnia, not by stimulants btw.
 
I've been prescribed all three for ADHD along with extended release methylphenidate.

Vyvanse/Elvanse worked just as well as dexamphetamine for the most part and there was less of a crash when it wore off. They both give a considerable energy/motivation boost along with the general executive dysfunction stuff.

It depends how long your days are really. Evanse was perfect for a 9-5 but when I was doing shift work I preferred Dex because I never knew when my day was going to start/end.

I was on methylphenidate for years but didn't really like it. It doesn't give the same kick up the bum amphetamines do and the crash is worse. It could also make me feel quite depressed at times. Just my experience so don't be deterred.

Whether you're on phenidates or amphetamines tolerance will become an issue eventually if you're taking it every day. A week off is usually enough to get your tolerance near enough back to baseline.
 
Vyvanse/Elvanse worked just as well as dexamphetamine for the most part and there was less of a crash when it wore off.
Click to expand...

That's my experience as well. Lisdexameftamine is weaker than dexamphetamine (about 60% as strong, I think) and has a fairly slow onset, but it works just fine and is overall a pretty smooth and functional form of stimulant. Methylphenidate can potentially be more exciting as it hits harder and faster, but it also has a bit of a crash to it as it drops off quickly, too.

If you can get what you need from any of those three, I would suggest just staying away from meth in any form.
 
JohnBoy2000 said:
I used to response to noradrenaline boosters.

Now they actually make me slow and tired.

I do however now respond to dopamine boosters.

Doctor has prescribed me 20 mg ritalin to be taken as needed. It's actually okay, but using everyday may make it less efficacious?
Possibly.

Where I'm at, lisdexamphetamine is available, but in terms of stimulating dopamine activity, I'm unsure how it compares to regular dexedrine?

I would go for dextroamphetamine ahead of the other mixtures with levoamphetamine, as I understand now I respond to pure DA enhancement with noradrenaline enhancement, and actually wish to avoid the latter.

Those who have used both or all three?

How would you compare them in terms of affect?

Increasing DA boosts motivation and focus I guess?
That's what I need right now.
Click to expand...
Ritalin? = Shit

Vyvanse? = Slightly less shit

DexAmp? = Majestic
 
every Vyvanse 20mg = 5.9mg of d-Amph .....3h onset /c-max lasts 10h or so. Pro-drug metabolism orally to API

Dexedrine Spansule & IR 1h onset lasts 5h - 8/10h

Ritalin IR 1h cmax with short 3-4h duration. Safest dopaminergic stimulant regarding cardiovascular side effect profile. 3-4X more dopamine over norepinephrine

D-Meth - DAT/SERT/NET
D-Amph - DAT/NET/SERT
MPH - DAT/NET

Adderall XR is probably the best Amphetamine salt combo 75/25 D/L with IR Dexedrine 5mg tablets to add more Dopamine when needed

Ritalin is easily the safest and VERY clean & Euphoric. Ethanol & 60mg IR Methylphenidate is extremely pleasurable A++ mood-boosting
 
Shinji Ikari said:
I've been prescribed all three for ADHD along with extended release methylphenidate.

Vyvanse/Elvanse worked just as well as dexamphetamine for the most part and there was less of a crash when it wore off. They both give a considerable energy/motivation boost along with the general executive dysfunction stuff.

It depends how long your days are really. Evanse was perfect for a 9-5 but when I was doing shift work I preferred Dex because I never knew when my day was going to start/end.

I was on methylphenidate for years but didn't really like it. It doesn't give the same kick up the bum amphetamines do and the crash is worse. It could also make me feel quite depressed at times. Just my experience so don't be deterred.

Whether you're on phenidates or amphetamines tolerance will become an issue eventually if you're taking it every day. A week off is usually enough to get your tolerance near enough back to baseline.
Click to expand...
MPH did give me a kick but had no [lasting] energetic / motivational boost. Dextro- Amphetamine, less then Racemic, gave no kick.
Just did its job. Never got a tolerance raise either or a crash on it, unlike MPH. Weird right ? I have surplus dex always. Mph never.
 
Yes, I can totally see your point. Methylphenidate is extremely short acting…..why I have BIPHENTIN XR 60mg capsules

40% of dose is IR ….remaining 60% of doses is released 4h after, reaching onset/peak in about 6h ….so about 10h of coverage

I usually pulverize the XR beads into fine powder so it’s all IR as I require about 60mg IR of Ritalin to feel its therapeutic effects…lasting 3-4 hours. I’ve never experienced any negative sideffects from Ritalin what so ever….except profound Euphoria and robust mood-boosting properties

If I had to choose an effective combo it would be:

Adderall XR 20mg beads
Dexedrine 5mg IR taken as needed to keep the “Oumph” of dopaminergic stimulant properties
Pregabalin (Lyrica) 150mg X 2 daily or a single 300mg on a fasted state 1.5h c-max
Alprazolam (Xanax) 1mg - Anxiolytic Benzo with antidepressant properties
Diazepam (Valium) 10mg X 2-3 tablets - Anxiolytic Benzo with robust muscle relaxant properties
Methadone 100mg (opioid tolerant individual) preferably Oxy-IR 20mg X 4-6 tablets as needed
Phenibut 1,500mg - 3h onset / c-max - potent anxiolytic + dopaminergic properties
Ethanol / Gin 2.oz X 3-6 cocktails every hour or so

The perfect oral Speedball / Brompton Cocktail 🍸 (multiple variations)

For a tolerant individual…..start low and go slow. Know your tolerance. Don’t be afraid to call 911 if needed. Specify, NO police and NO fire department…..just an EMS bus with NO sirens, to monitor vitals such as BP/HR and ensure your safety is ensured. Don’t be shy or scared to call 911 if needed ….I’ve done it twice before

My fckn tax dollars at work, my safety is paramount…..know your limits and tolerance

Educate yourself about any DDI’s and be aware of your cardiovascular health / medical issues …especially with dopaminergic stimulants such as Adderall and Amphetamines in general. They all carry “black box warnings” and try having rescue meds on hand just in case….

Be safe and have fun :)
 
Halif2 said:
That's my experience as well. Lisdexameftamine is weaker than dexamphetamine (about 60% as strong, I think) and has a fairly slow onset, but it works just fine and is overall a pretty smooth and functional form of stimulant. Methylphenidate can potentially be more exciting as it hits harder and faster, but it also has a bit of a crash to it as it drops off quickly, too.

If you can get what you need from any of those three, I would suggest just staying away from meth in any form.
Click to expand...

What dose of methylphenidate have you used?
 
Dextro .45 said:
every Vyvanse 20mg = 5.9mg of d-Amph .....3h onset /c-max lasts 10h or so. Pro-drug metabolism orally to API

Dexedrine Spansule & IR 1h onset lasts 5h - 8/10h

Ritalin IR 1h cmax with short 3-4h duration. Safest dopaminergic stimulant regarding cardiovascular side effect profile. 3-4X more dopamine over norepinephrine

D-Meth - DAT/SERT/NET
D-Amph - DAT/NET/SERT
MPH - DAT/NET

Adderall XR is probably the best Amphetamine salt combo 75/25 D/L with IR Dexedrine 5mg tablets to add more Dopamine when needed

Ritalin is easily the safest and VERY clean & Euphoric. Ethanol & 60mg IR Methylphenidate is extremely pleasurable A++ mood-boosting
Click to expand...
If you took 20 mg IR ritalin, waited three hours, then took another 20 mg IR, what affect would you expect?

One compounding the other?

Or is that too long between doses?
 
No that exactly how BIPHENTIN works….formulated for Biphasic release, hence the name

Methylphenidate takes 1h to reach effects, lasts for 3-4hours ……by the time you took your second 20mg tablet the effects from the previous dose would be ending

I’ve been taking for 10 years and 240lbs 6’ …..so 60mg IR at once is my dose

Someone else, 10mg would suffice ….a single 20mg tablet is adequate to enduce euphoric effects for a new user, easily.
 
Dextro .45 said:
No that exactly how BIPHENTIN works….formulated for Biphasic release, hence the name

Methylphenidate takes 1h to reach effects, lasts for 3-4hours ……by the time you took your second 20mg tablet the effects from the previous dose would be ending

I’ve been taking for 10 years and 240lbs 6’ …..so 60mg IR at once is my dose

Someone else, 10mg would suffice ….a single 20mg tablet is adequate to enduce euphoric effects for a new user, easily.
Click to expand...
In your experience, after a new user commences it at say 20 mg per day, how much time would elapse before they'd begin to notice tolerance emerging?

A couple weeks?

A couple months?

Does taking a break for a couple days from time to time, help to reset such a tolerance?
 
emkee_reinvented said:
MPH did give me a kick but had no [lasting] energetic / motivational boost. Dextro- Amphetamine, less then Racemic, gave no kick.
Just did its job. Never got a tolerance raise either or a crash on it, unlike MPH. Weird right ? I have surplus dex always. Mph never.
Click to expand...
I would imagine this is subjective/individual?

I used to respond well to noradrenaline boosters, now they make me tired.

Dopamine lights me up currently. Historically I couldn't even really notice it.

Right now, looking for something DA specific, one would think dextroamphetamine is choice.
 
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