Tryptamines Rhodiola rosea and tryptamines

[Pissed_and_messed]

Has anyone tried rhodiola rosea with psychedelics? Like shrooms, which is metabolized by MAO-a. I just realized I could try this, could make it stronger experience than utilizing dark chocolate. Rhodiola rosea is reversible mao-a-i and mao-b-i.

I choosed prefix "tryptamines" but I realized that as mao-b-i it could possibly decrease metabolization of phenethylamines too, eh? I am not sure how PEA-analogs are processed in the body.

 

[red22]

Most natural MAOIs are extremely weak: https://www.bluelight.org/community...ute-for-dmt-in-ayahuasca.941251/post-16114386

The second page at the bottom of that post says it's an extremely weak MAO-B inhibitor and and says there's no data for MAO-A.

 

[Pissed_and_messed]

Okay, I got that wrong maybe. It made oral PEA active tho'.


Well, maybe I check your link at least.

 

[red22]

No, it's too weak for that. It has an IC50 value of 4.8; harmine, by contrast, has an IC50 value of .020 (for MAO-A) (lower values = stronger inhibition,* i.e., I think it works like "smaller molecules can slip through more cracks"). .020 is 240 times smaller than 4.8.

For the record, selegiline does work to enable beta-phenethylamine is have an effect like alpha-methyl-phenethylamine (amphetamine): Too much Phenylethylamine (PEA)?


*“Lower values of IC50 and higher values of pIC50 represent more potent inhibitors.”

A Review of the Current Landscape of SARS-CoV-2 Main Protease Inhibitors: Have We Hit the Bullseye Yet? Macip G, Garcia-Segura P, Mestres-Truyol J, Saldivar-Espinoza B, Pujadas G, Garcia-Vallvé S. Int J Mol Sci. 2021 Dec 27;23(1):259. doi: 10.3390/ijms23010259 (2.1. Activity Assays for Identifying SARS-CoV-2 M-Pro Inhibitors, p. 7)