Sorry to bump such an old thread, but I just had to share my experience with this drug:
-Took 4mg of Clonazepam and 1200mg of Lyrica everyday for 1 year (a bit less probably, like 10 months)
-After that the Lyrica stopped working, it felt as if I was taking sugar pills, but felt no withdrawal
-These things that helped me the most: Using a high dose of memantine (helped the most) and an extremely low dose of amisulpride (25 to 50mg), I personally believe memantine helped the most, but still, it never felt as the first time I tried Lyrica.
The rationale for using the Amisulpride is that it upregulates GHB receptors (although I don't know if it achieves this at the low doses I used, but at such low doses it would elevate Dopamine levels by blocking Dopamine autoreceptors), Lyrica potentiates the enzyme that transforms Glutamate to GABA (Glutamic Acid Decarboxylase) and so elevates global levels of GABA which in turn transform into GHB activating GHB receptors, hence the "XTC feeling" it gives you. I may be wrong though, or it could have been placebo, but at least in my case, it kinda worked.
The rationale for using memantine is simple: it blocks NMDA receptors, and I found anecdotical reports that it greatly potentiates Lyrica. Some of those reports even here in Bluelight.
LaCster also recommended me (via PM) to combine Lyrica and Gabapentin, "Super Lyrica" we called it, but not at the same time because they are absorbed by the L-aminoacid transporter and so they compete with each other. He also recommended using DXM instead of Memantine. Using Gabapentin worked very well I must say, and DXM was ok and it will definetily help you too if you can't get Memantine.
I've never shared this with anyone so I hope it helps or inspires someone,
Charles Ferdinand.