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  • BDD Moderators: Keif’ Richards

Reversing damages opiate receptors

F

Feelin-u4ia

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Sep 11, 2013
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We might die from all the medication, But we sure
So the title pretty much sums it up? Iv had a little too much fun with hydro n oxy in my life 300-450 mg doses of either oxy or hydro all in one dose. Anyways now days the effects have gone away so dramatically I really don't even feel the high effects. I have tried waiting like a week to 9-10 days in between doses but still gettin similar results. I'd hate to have to jump to like 500 mg to feel something cuz that sounds awfully high and would prolly screw my tolerance up even worse Than it is. Anyways besides waiting a few months or even years Is there anything I can do to help faster rebuild my opiate receptors and shit like that?
 
Feelin-u4ia said:
So the title pretty much sums it up? Iv had a little too much fun with hydro n oxy in my life 300-450 mg doses of either oxy or hydro all in one dose. Anyways now days the effects have gone away so dramatically I really don't even feel the high effects. I have tried waiting like a week to 9-10 days in between doses but still gettin similar results. I'd hate to have to jump to like 500 mg to feel something cuz that sounds awfully high and would prolly screw my tolerance up even worse Than it is. Anyways besides waiting a few months or even years Is there anything I can do to help faster rebuild my opiate receptors and shit like that?
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Abstinence is the only way. I took a 3 month break and my tolerance did drop, but within a day or 2 it was back to where it was before I had a break.
 
The only thing that could help is stopping but even with stopping it may never be the same that's how you end up on heroin searching for the old days, if you switch to another d.o.c. You could find your less tolerant to opana, or diladud something like that, but even with a year abstinence your gonna catch a few days at where you started and be back up to frustration.
Best to stop the chase and live your life, best to you either way.
 
it could take awhile

Try switching to a drug other than an Opiate for the time being, like weed or something
 
It's may be difficult, but abstaining from opiates is the only way for the brains opiate receptors to recuperate. I've heard some fucking bizarre schemes to try and cheat tolerance, including one person who would periodically shoot naloxone to "reverse" his tolerance, claiming it set it back to zero...and that was actually one of the saner ones I've heard.

As as been posted already, it's tolerance that's the problem; opiate receptors can't be permanently damaged by taking opiates. So, you really need to take a break - it's the only way that works. Of course, this is easier said than done, because stopping completely is obviously gonna mean some withdrawals, and we all know how nasty they are.
 
dopemegently said:
It's may be difficult, but abstaining from opiates is the only way for the brains opiate receptors to recuperate. I've heard some fucking bizarre schemes to try and cheat tolerance, including one person who would periodically shoot naloxone to "reverse" his tolerance, claiming it set it back to zero...and that was actually one of the saner ones I've heard.

As as been posted already, it's tolerance that's the problem; opiate receptors can't be permanently damaged by taking opiates. So, you really need to take a break - it's the only way that works. Of course, this is easier said than done, because stopping completely is obviously gonna mean some withdrawals, and we all know how nasty they are.
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Odd thing with me is I do not get any physical wds other then for some anxitey (but anxiety has kinda always played a role in my life) I am very lucky to be able to say that..
 
This doesn't make sense, there isn't anyway you could do those doses with out dying unless you were an addict. Meaning you would have to be doing it daily to build tolerance that big, so how do you just simply take 10 days off and come back on as if you don't need it daily? Also i still don't understand how after 10 days you still don't catch a strong buzz off 500 mg. I have been using opiates on and off for years, 15mg hydro still puts me in my zone. It may just be your body, there is nothing you can do besides wait at least a few months or years and then come back to it slowly.
 
I am as confused as you are bud, there was probably a period of 2 or 3 months where I took it daily for pain, after that it became like every 2-4 days whenever is be able to get it, and now that my tolerance is where it is I'll take 7-9 days off and try again over and over with no good result. I just don't understand how someone can take 500 mg and still not get all kinds of high! And yes for example I'm on day 5 of what most call "wds" but I'm fine as always... Ofcourse besides the urges, and cravings which is why in on here posting probably...
 
Psychedelic Jay said:
You can't reverse damage and still use...

This isn't even damage, it's just tolerance.
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As others have said. Chronic, high dosing doesn't damage the receptors (or any of the bodys opiate systems). It's actually a process called tachyphylaxis, desensitation and tolerance (on the molecular level a number of processes are occurring; receptor phagocytosis, deregulation of protein expression, blah blah).

Again, absence is the only "cure". Your body will return to a point of initial homeostasis. How long this will take? Too many variables (individual biovariability, previous dose and time frame, etc.) really to give a realistic time span imo.

Regardless, good luck bro! :)
 
tyrael said:
As others have said. Chronic, high dosing doesn't damage the receptors (or any of the bodys opiate systems). It's actually a process called tachyphylaxis, desensitation and tolerance (on the molecular level a number of processes are occurring; receptor phagocytosis, deregulation of protein expression, blah blah).

Again, absence is the only "cure". Your body will return to a point of initial homeostasis. How long this will take? Too many variables (individual biovariability, previous dose and time frame, etc.) really to give a realistic time span imo.

Regardless, good luck bro! :)
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Thanks for your reply! Great info, with that being said do u think a month of no use will put me back to atleast even feelin euphoric with even the same 400-500 mg dose? Once again I know it's hard for u to work it out as there are manly variables but you seem to be very knowledgable about this just figured maybe u can throw out a ball park answer. Since obviously abstinence is they answer.
 
I'm very hesitant in giving specific numbers (kinda goes against not just BL but my own ethics :\ ).

Both hydrocodone and oxycodone have short half-lives (~5hrs), so within a few days your body should have eliminated most/all of the physical chemical.

Tbh, 300-450mg of hydro/oxy are extremely large doses (oral ROA I assume?).

How long have you had this habit, at this degree, for? At a guess I'd say try a month. :\ However everyone's physiology is different.

A few caveats though;
1. By the sounds of it you'd be a "heavy users" so most likely no matter how long, you'll always have somewhat of a tolerance. Also you'll find after a break (and possible loss of tolerance), your tolerance will build back again quicker than originally.
2. After coming back from "a break", dont go back to your original dose! Quick fire way to OD.
3. If you're having trouble stopping, try titrating your dose down over a week period (or so). It'll help with w/d's and probably give you a higher chance of actually stopping.
4. Even better, enter yourself into an ORT program and get off the stuff for good! ;) :D
 
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tyrael said:
I'm very hesitant in giving specific numbers (kinda goes against not just BL but my own ethics :\ ).

Both hydrocodone and oxycodone have short half-lives (~5hrs), so within a few days your body should have eliminated most/all of the physical chemical.

Tbh, 300-450mg of hydro/oxy are extremely large doses (oral ROA I assume?).

How long have you had this habit, at this degree, for? At a guess I'd say try a month. :\ However everyone's physiology is different.

A few caveats though;
1. By the sounds of it you'd be a "heavy users" so most likely no matter how long, you'll always have somewhat of a tolerance. Also you'll find after a break (and possible loss of tolerance), your tolerance will build back again quicker than originally.
2. After coming back from "a break", dont go back to your original dose! Quick fire way to OD.
3. If you're having trouble stopping, try titrating your dose down over a week period (or so). It'll help with w/d's and probably give you a higher chance of actually stopping.
4. Even better, enter yourself into an ORT program and get off the stuff for good! ;) :D
Click to expand...


Ya that is the best advice but I'm going to try dosing just once a month now with prolly a 350 mg dose. I used to be pretty addicted to this stuff but not anymore, I used to crave it so badly I couldn't go 2 or 3 days without it, now I regularly take a week or two completly off, with no signs of physical wds at all, strange?

I have been using mainly hydro for about 8-9 months? I started off with maybe 15-20 mg per dose and within two weeks or so 40-60 mg pee dose than after that I started cwe to prevent liver damage, ofcourse cwe has loss age in product so I upped it to about 100 Mgs, another week or so later by the time I hit 150 Mgs thats where it got out of hand and I quickly shot up to 300, 300 worked for a little while then shortly after I reached doses of 350-500 with almost no euphoric effects anymore, even my highest dose ever recently of 510 mg I just kinda felt weird, probably overdose lol but my body is just too adapted to these doses. Idk thank u all for any options, opinions, comments
 
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