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Reverse tolerance

yes frump, something similar to that. however its been quite awhile since i was at that stage, now i'm back up to having to smoke more, just to get that shortened high.

imo its deffinately time for a break. just hard to fucking do.
 
This is regarding Frump's post.

I read recently -- I can't the source, but it was quite mainstream -- that studies had shown that regular pot smokers metabolized THC more quickly than occasional pot smokers. This wouldn't contradict the reverse tolerance theory in terms of intensity. I'll try to find the article.

A friend, who is a real head, took a month off due to pneumonnia, and when he took his first toke he was just smashed and for quite a long time. He told he hadn't expected it to be like that all given that the weed had been sitting around and he was just barely inhaling.
 
Actaually, I know of quite a few study which says that heavy marijuana smokers metabolise pot more slowly... Well that is to say, the excrete THC slower.
 
reverse tolerance: I know nothing about the fat solubility concept, but if you are smoking one certain strain of marijuana for a while (either you grew or get from the same source who only grows one strain) and you switch to a diff strain which may not be as potent, you will get wayyy higher. I learned this from experience.
 
the only reference i had, besides my pysch. teacher, was the nixon report i posted earlier.
i'd like to find out what causes it tho, because to my knowledge it is unique as far as drugs go.
 
Well most of my references aren't stand alone, and the result in question isn't stated in the abstract. But if anyones got access to a medical library:

Ellis GM Jr, Mann MA, Judson BA, Schramm NT, Tashchian A.
Excretion patterns of cannabinoid metabolites after last use in a group of chronic users.
Clin Pharmacol Ther. 1985 Nov;38(5):572-8

But then theres:

Johansson E, Agurell S, Hollister LE, Halldin MM.
Prolonged apparent half-life of delta 1-tetrahydrocannabinol in plasma of chronic marijuana users.
J Pharm Pharmacol. 1988 May;40(5):374-5


The problem with all these studies is abstinance and study length, although that top study is the longest urine cannabinoids study out there.
 
Ellis and colleagues
The urinary excretion patterns of 86 chronic cannabis users were examined after their last cannabis use by two common screening methods (...). We demonstrated that under very strictly supervised abstinence, chronic users can have positive results for cannabinoids in urine (...) for as many as 46 consecutive days from admission, and can take as many as 77 days to drop below the cut-off calibrator for 10 consecutive days. For all subjects, the mean excretion time was 27 days (...). Demographic, body type, and drug history variables proved to be only moderate predictors of excretion patterns."
Ellis GM Jr Mann MA Judson BA Schramm NT Tashchian A. Excretion patterns of cannabinoid metabolites after last use in a group of chronic users. Clin Pharmacol Ther 1985;38(5):572-578.


Rolf Aderjahn
Excretion of THC and its metabolites in chronic users can be found in the range of 4-6 weeks. In the literature a 10 year long intensive cannabis use was reported to result in detection of use after 77 days with common tests. With single or occasional use excretion in urine is rarely short (some hours), usually it lasts for 3-5 days.
Aderjahn R. Toxikologischer Cannabisnachweis [Toxicological cannabis detection]. In: In: Berghaus G, Krüger HP, eds. Cannabis im Straßenverkehr [Cannabis in road traffic]. Stuttgart: Gustav Fischer, 1998.
 
I can agree with this to some extent. after smoking daily for a year a year now it takes more to get me high, but when i first started smoking it definitely took less to get me high if i had smoked the day before. I atttributed this to the fact that weed is indeed fat soluble and was still in my system, just not enough for me to get high. a couple tokes later though....
high as a kite

another commment: it took a lot to get me high the first time, but a few days later it didn't take much at all. i think its cuz the thc was still in my system in far greater amounts than when i was a weed virgin.
 
thats really an interesting theory bowdenta...now when i think about it back when i used to go running every night for about a half an hour it kept me from getting those intense highs that led to panic attacks like ive been having recently
 
I have no idea, but I definitely agree with reverse tolerance. I mean everyone has heard of some people not getting high their first time. It could be because there is already thc in your system from before and plus you are just better at smoking. Sorry if this doesn't make sense I just smoked 2 bowls of some blueberry with a friend and I'm fried.
 
i think some of you are being misled here by what i was talking about.

i know what your saying about the first time taking a large amount, then the next time taking less.

however what i'm speaking of occurs after the user has been habitually indulging for a long while. it happened to me at around 1 yr.
my tolerance was going up and up, and it would take more and more to get me high.
then it started in the other direction. less and less would get me high, just not as high as i had been getting. the high had changed, but it took less to achieve it.
 
The one year mark is a point when many people invest in more efficient means of getting high, and better sources. It could be that you needed less because you were no longer smoking mexican brick out of j's, but dankiest of the dank out of bongs.
(Or you could simply be smoking more potent weed).
 
ev0l said:
Ok, this info is from my psyc. teacher at a college I attend, so its valitidy is up to you. He claimed during a discussion on various drugs that weed has a very unique tendancy to cause a reverse tolerance in habitual users. Basically after long use, not sure of the time frame, maybe years, but anyways it eventually takes less and less to get high, you just can't get as high as a noob would. Something to do i believe w/ the fat solubility and extreme habitual users. I've noticed it at around 1.5 years, now been 3 and i was curious to know if anyone else had the same experiece?


i believe and have experienced such a reverse tolerance too, but it seems to me that it all depends on how much u smoke, in fact, i believe that when u smoke on a daily basis u wont experience this reverse tolerance, never ever. or maybe it's just me?

when u smoke everyday u build up tolerance and u can longer see the tru "power of ganja";)
i v tried it several times...daily usage is not a good idea ithink, there were times when i smoked at least 2 gr a day, and the high i experienced was nothin compared to what i should be, it no longer pleased me, i got bored with it and i no longer wanted to use it (temporary offcourse)

on the other hand: i also experience that when u smoke moderately, only once in a while ( let s say once a week ) u can experience this reverse tolerance. sure. that s why ganja is such an interestin and fine drug, i m not thinkin of quitin ever. =D
 
yimmy12 said:
I have no idea, but I definitely agree with reverse tolerance. I mean everyone has heard of some people not getting high their first time. It could be because there is already thc in your system from before and plus you are just better at smoking. Sorry if this doesn't make sense I just smoked 2 bowls of some blueberry with a friend and I'm fried.

it has nothin to do with gettin better at smokin, accordin to me. i think it has to do with the nature of the drug it self. u cant compare it with for instance alcohol, alcohol is a very straightforward drug, it wont surprise u. u always know what ur gonna get and the more u drink, the more effect u ll have and the more often u do it the more u ll need to have the same effect. ganja is very different, first time users r either blown away or experience no high... i think u have to "learn" to use it , the only way to learn is to smoke it offcourse =D
 
ev0l said:
i'd like to find out what causes it tho, because to my knowledge it is unique as far as drugs go.

personally i think sometimes it's better not to know %) just my 2c's . i dont care about the science that's behind it, it's irrelevant to me.
 
alien8ed said:
The one year mark is a point when many people invest in more efficient means of getting high, and better sources. It could be that you needed less because you were no longer smoking mexican brick out of j's, but dankiest of the dank out of bongs.
(Or you could simply be smoking more potent weed).

not in my case. i started out on krip. b/c i still lived w/ the rents and had a full time job during highschool. i only switched to regs when i moved out because of money issues. but that was after the event.
when i first started it was only water bong use. occasional pipe or blunt. usually water bong. eventually tho it got to where one bowl would get me as high as i could get, smoking more would only extend the high, not raise it. any one else get this later on in their smoking career?
 
i seem to have a reverse tolerence as well, the first 12 times i smoked i didnt feel anything and it was all top quality buds. always with a bong soo i know i inhaled corectly. now one good binger and im pretty decently high. however i find that a bag doesnt last me as long as it used to
 
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