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Reverse Drugs?

L

LaserHosen

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Probably not the most original idea ever, and I did thing twice about starting a new thread in favour of sticking this in an existing thread.

But here's my question anyway:

Are there any drugs that when you take them they give you nasty effects right away and then bestow positive effects on you afterwards?

Like instead of a high, then a comedown you have a shitty negative effect first and then get benefits later.
 
You could say that the profile of a psychedelic can often fit this definition, or at least, a "difficult trip" - it raises issues that are uncomfortable at the time but providing long lasting benefits.
 
I've always mused on the idea of taking Ro15-4513 or Flumazenil at very very low doses and slowly working my up as tolerance sets in. I would assume this would slowly cause upregulation of the GABAa receptors. If you went too fast, I would also assume the process would be horrible and anxiety inducing, much like a benzo withdrawal. When you stop or taper back down, the withdrawal would be like taking benzos. I would never actually do this of course, but it's fun to think about.

I've also considered the thought that some people say after they are addicted to benzos at high doses for a long time, once they work their way back down, they never feel like their anxiety completely returns to how it was before the extreme benzo addiction. That made me think, maybe if you could keep an antagonist/inverse agonist in your body for a year, maybe when you stopped your anxiety would be cured? Or maybe you'd die from a seizure long before that, haha.

This is just speculation. I doubt anyone has every been crazy enough to try this, and I'm not a master of pharmacology. This is just the kind of things I think about when I'm bored.
 
Psychedelics are a bit like that.. It's often more pleasant when the peak starts to fade.
Once with mushrooms I had a very rough trip and, although the trip had already turned positive and fun halfway in, being back to baseline brought a new high. While otherwise completely sober, I got very confident and sociable for a few hours.
 
cegli said:
I've always mused on the idea of taking Ro15-4513 or Flumazenil at very very low doses and slowly working my up as tolerance sets in. I would assume this would slowly cause upregulation of the GABAa receptors. If you went too fast, I would also assume the process would be horrible and anxiety inducing, much like a benzo withdrawal. When you stop or taper back down, the withdrawal would be like taking benzos. I would never actually do this of course, but it's fun to think about.

I've also considered the thought that some people say after they are addicted to benzos at high doses for a long time, once they work their way back down, they never feel like their anxiety completely returns to how it was before the extreme benzo addiction. That made me think, maybe if you could keep an antagonist/inverse agonist in your body for a year, maybe when you stopped your anxiety would be cured? Or maybe you'd die from a seizure long before that, haha.

This is just speculation. I doubt anyone has every been crazy enough to try this, and I'm not a master of pharmacology. This is just the kind of things I think about when I'm bored.
Click to expand...

Kinda of like Naltrexone.

Anything is possible. Theoretically.
 
ibogaine will, literally (relative to your mind's observation of the experience), send you skyrocketing into space with loud noises for the most brutal trip you'll ever experience, lasting a whole day, and then for about 6 months afterwards your life will feel whole like a big puzzle that's finally been put together and everything just-- makes-- sense!!! supreme complacency!

of course u would need to go to a country where they'll administer it in a controlled setting.
 
Opoid antagonists don't cause opiate withdrawal symptoms in non opiate dependent people. They're competitive antagonists (they bind to receptor fairly strongly, so they kick the other drugs off, but they don't activate the receptor). So that doesn't work.

And yeah, the anti-benzo is an interesting idea.
 
Well this is really a hard criteria to fulfill.

I don't have any illicit/psychedelic drugs, but accutane isn't so much fun right away when it makes your pores start emptying. After that is over and everything heals up it is smooth sailing.

Another possible example is if you consider gonadotropin-releasing hormone analog therapy for cancer. GnRH analogs overstimulate their receptors which results initially in large release of estrogen or testosterone (pending your sex; generally this is not good for cancer) but after about 10 days the receptors downregulate and serum levels of the sex hormones fall drastically. From then on as long as you are on the therapy your levels of sex hormone will be low and this is effective at helping treat certain types of cancer.

http://en.wikipedia.org/wiki/GnRH_agonist
http://en.wikipedia.org/wiki/Histrelin
 
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