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Researching Agonists/Antagonists/Reuptake Inhibitors/Releasers

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pharm-boy

Greenlighter
Joined
Jul 15, 2012
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18
Location
UK
Hello, is there some sort of established method for searching for chemicals that have activity with certain receptors/neurotransmitters? I'm aware that Wikipedia does have some lists to this effect but they are by no means complete.
 
Well the easiest way would probably be a bluelight search, if the mechanism of action is common knowledge, someone will have discussed it here.

Besides that you could try a pubmed search along the lines of "(drug of interest) + (receptor of interest) + Ki" or something along those lines. For example if you search "cocaine, dopamine transporter, ki" the fifth result would give you what you're looking for. Or even simpler search "(drug of interest) + mechanism of action".

If it's some obscure chemical that has next to no research on it, you're probably out of luck.
 
Probably out of luck then. I was looking for TRPV3 agonists - I came across a study that showed frankincense resin contained a chemical they named "incensole acetate" had an antidepressant/anxiolytic effect related to TRPV3, so thought I'd look a bit more into other chemicals with an affinity for the receptor in order to do some research. Seems to be hardly any info available though.

Edit: Here's the study if anyone's interested - http://www.fasebj.org/content/22/8/3024.short
 
pharm-boy said:
Hello, is there some sort of established method for searching for chemicals that have activity with certain receptors/neurotransmitters? I'm aware that Wikipedia does have some lists to this effect but they are by no means complete.
Click to expand...

go there:
http://www.acnp.org/publications/neuro5thgeneration.aspx

then you can search each nerotransmiter like gaba, dopamine, serotonine with a key words like, inhibitor, analog, agonist, anti agonist. receptor ligands , reuptake inhibitors, transaminase inhibitors and what not.
 
Quercetin said:
go there:
http://www.acnp.org/publications/neuro5thgeneration.aspx

then you can search each nerotransmiter like gaba, dopamine, serotonine with a key words like, inhibitor, analog, agonist, anti agonist. receptor ligands , reuptake inhibitors, transaminase inhibitors and what not.
Click to expand...

Brilliant, thank you so much for that. For anyone else looking, that link gives you all sorts of in-depth info on neuropsychopharmacology, including what I was looking for :)
 
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