N&PD Moderators: Skorpio
Research alcohols, carbamates and antique sedatives
Smyth2
Bluelighter
https://en.wikipedia.org/wiki/Diacetone_alcohol
Although it's not worthwhile now because much more superior options are on the table.
These were archaic designs.
sekio
Bluelight Crew
best I can find is that N-ethylurethane disrupts embryonic development
The influence of N-ethyl urethane on the early development and nucleic acid metabolism in the embryos ofMicrohyla ornata - Discover Developmental Biology
1. The effects of N-ethyl urethane on the development ofMicrohyla ornata have been studied. 2. The embryos treated at early gastrula stage showed a disorganization and lack of differentiation of various organs. A range of abnormalities includes oedema, dwarfism, bent trunk or tail, brain and eye...
link.springer.com
diacetone alcohol smells awful btw I don't want to be the first to drink it
yeah, like, diethylbarbituric acid (Veronal) or maybe chloral hydrate? potassium bromide?
Smyth2
Bluelighter
There's an alcohol called Wormin (1-Bromo-2-naphthol) [573-97-7].
Also another alcohol called Meparfynol (3-Methylpent-1-yn-3-ol) [77-75-8].
I'm not know on the laws but theoretically to spike someones drink.
The carbamate is called Anansiol (Calminol).
I thought Phenbarbital is much superiot to Veronal, although only Primidone is for sale openly online.
Smyth2
Bluelighter
Bason [2028-52-6].
In silico prediction of central nervous system activity of compounds. Identification of potential pharmacophores by the TOPS–MODE approach
The central nervous system (CNS) activity has been investigated by using a topological substructural molecular approach (TOPS-MODE). A discriminant analysis to classify CNS and non-CNS drugs was developed on a data set (302 compounds) of great
www.academia.edu
The effect of halogenation on the hypnotic and anticonvulsant activities of acetylenic carbinols - PubMed
The effect of halogenation on the hypnotic and anticonvulsant activities of acetylenic carbinols
pubmed.ncbi.nlm.nih.gov
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My stomach still turns at the thought of the smell of formaldehyde-pickled crawfish in high-school science class, and that was over 13 years ago. Some of us are naturally sensitive to aldehydes (one sign is thinking cilantro tastes like soap.)
Nagelfar
Bluelight Crew
Sounds like how Vick's inhaler uses "Metamfetamine". Which is on the label, but a Google search doesn't even take that spelling with "Vick's inhaler" added in any of the top results. Which is ironic.
Rectify
Bluelighter
I've always wanted to try 1-propanol and 1-amyl alcohol. Reportedly, they are shorter acting and less hangover prone than ethyl alcohol. Depressants, while they can be fun, are just not really my thing. I get reckless.
Combining 1,4-butanediol with clonazolam was something that I once did which I never wish to repeat.
plumbus-nine
Bluelighter
Long time ago, during the MXE era, some RC alcohols were briefly available. I'd acquired 2-methyl-2-butanol and another one I forgot. The 2M2B tasted minty with a slight chemical hint as far as I remember, it would take some experimenting but would say you could make tasteful cocktails with it. I titrated slowly and was just a little bottle so didn't catch a full drunk experience but it was certainly active and pretty alcohol like. As it is much more potent than ethanol, it would be interesting if this also means the liver gets much less load.. of course being such potent, it's easy to overdose and without tolerance the equivalent of 2-3 bottles of vodka aren't exactly healthy..
Certainly interesting cause I as I am forced to abstain from illicit drugs and turned to alcohol from time to time, a legal, more potent replacement would be nice.
@Synaps3 Tried to read your paper but it says that it isn't available to the public 
sekio
Bluelight Crew
Sci-Hub: knowledge belongs to all mankind
Sci-Hub website. Get free access to academic journals. Download research papers for free from ScienceDirect, IEEE, Wiley, Springer, Nature and others
sci-hub.se
it's also inactive. The only "drug type" butanediol is the 1,4 isomer. The others: 1,3-butanediol, 1,2-butanediol, and 2,3-butanediol are all inactive
Smyth2
Bluelighter
Hey anyway, @sekio
Here is the reference for diacetonealcohol: 10.1016/j.jtcme.2015.01.004 i5163-BWI, cX
I made this in the lab also 20 years ago.
simstim
Bluelighter
Years ago I started ordering methocarbamol online and using it in high doses (over 4 grams per dose) as a sedative/muscle relaxer. I really liked the action of it although the half life is short. It is very calming and relaxing and it also has this effect where it makes your face and tongue go numb like you did some coke or something.
Anway, methocarbamol is the carbamate of the drug guaifenesin.
Another drug mephenesin is the 2-methyl analog of guaifenesin (which is 2-methoxy) and mephenesin is a sedative/muscle relaxer.
So I found out that if you take 4500mg of guaifenesin it TASTES like methocarbamol, FEELS like methocarbamol, and EVEN NUMBS YOUR FACE like methocarbamol so I could see using some of these alcohols that are the base of a known carbamate drug like I do with guaifenesin as someone suggested above.
What do you guys think about 2-phenylethanol? The base alcohol for phenprobamate?
Xorkoth
Bluelight Crew
Ethanol metabolizes to acetaldehyde, but ethanol itself is the primary active substance, acetaldehyde is the toxic metabolite responsible for most of alcohol's toxicity.
Xorkoth
Bluelight Crew
You can get high from guaifenesin? Does it make you throw up or anything? Seems sketchy, but maybe that's just my perception due to always telling people not to take DXM products with guaifenesin in them.
Huh... the wiki on it is interesting. It lists it as having muscle relaxant properties and is routinely used in large animal veterinary surgery. It also lists both diarrhea and constipation as side effects
Mephenesin is otc in France , tried to get high with it and kept falling over , turns your muscles into complete jelly. So yes not a experience worth repeating.
simstim
Bluelighter
I definitely recommend people to avoid guaifenesin with DXM for multiple reasons. The top reason is that the COMBINATION causes wicked nausea, but also it really changes the character of the trip and makes me feel sick.
It really does change the visuals, too. This happened to me the last time i did DXM and it was exactly like the one time when I took a few grams of methocarbamol mixed with 3-meo-pcp. I puked that time too and the visuals were BIZARRE! I was completely dissociated and puking. No clue what was going on.
Did you notice that one of the mechanisms of action suggested on the guaifenesin wiki article was NMDA receptor antagonism on top of whatever MOA causes the alcohol-like sedation and muscle relaxation.
Guaifenesin by itself has never made me sick and like I said I usually eat 4.5 grams of it at a time.
It feels great and is cheap/legal. The only downside is the short duration. It doesn't last more than a couple of hours with instant release guaifenesin.
simstim
Bluelighter
According to wikipedia it is active without the carbamate substitutions. 2,2-diethyl-1,3-propanediol is listed as active on wikipedia as well and used to be a precsription drug called Prenderol that was used for certain types of seizures and various other indications.
All I can find is 2,2-dimethyl-1,3-propanediol aka neopentyl glycol. I can't find any info about if that one is active though. Not one single scrap of evidence that it was ever even trialed.
izo
Bluelighter
the first is a little less potent than ethanol, the second almost inactive.
Synaps3
Bluelighter
Prenderol might work, but I don't think it will be very potent and will probably be VERY short acting. That's why they always used the dicarbamates of the diols whereas you can find some tertiary mono-alcohols that were used on their own back in the day (such as methylpentynol and 2m2b). The diols have to be dicarbamated in order to prevent super rapid oxidation of each carbon next to the OH.
Furthermore, I did try 2-methyl-2-propyl-1,3-propanediol and noticed this exact problem - super short - super weak - smells like sperm - not worth it at all. I talked a little more about it in my other thread "review of my favorite gabaergics". I just called it propanediol in there cause the name is too long.
You mean 3-phenyl-1-propanol. AKA Saturated Cinnamyl alcohol. I bought that a while back when I was researching these. It's not consumable due to its EXTREME SMELL. It would be like drinking some pure essential oil. It doesn't even seem to have the properties of an alcohol; it's like an oil.
