req: BL User experience/ advanced knowledge of Codeine "Ceiling Limit" to dose
OK I've been doing codeine a long time.... 8 years now? 9? The first few are a blur. I gather I'm one of the lucky ones in terms of metabolism into morphine.
Anyhow, past experience led me to believe there was a ceiling dose to codeine. From what I've read it varied widely, mine seemed to kick in somewhere between 400 - 500 mg. To give you an idea of my conversion rate at the point I was taking 500mg doses of codeine I had to take 80mg oxycodone (no time release) to get to the same place. This isnt an exact comparison due to the difference in feeling, but close enough to give an idea. In neither case was I anywhere near nodding, which I used to do (only in the beginning, and rarely) at just 150-200mg codeine.
I started pushing my dose over time up to a little further than 500ish as my tolerance built, not achieving any enjoyable gains, but noticing a slight improvement up to about 700mg. It was never really 'worth' upping the dose beyond what I thought was the ceiling, but you know.. any tiny gain.
Needless to say at this point I was doing the most efficient CWEs humanly possible.
Now as I understand the metabolism of codeine to morphine is inhibited by morphine itself, but codeine-6-glucuronide which (may) has/have a very mild analgesic/euphoric effect is still metabolised. Or at least this was what people proposed from my readings.
In the neverending quest to get high like the old days, I've started to wonder if it's possible to take a high enough codeine doseage to push the codeine-6-glucuronide levels up to a level that will actually have a strong impact.
Just wondering what people's personal experience with the so called 'ceiling' dose of codeine are - in general and particularly if you've experimented with going way beyond it. My first experiment is 1000mg, minus loss through inneficiency, which - conservatively - I'd say would be no more than 10%, probably more like ~5.
Unfortunately nobody really knows to be able to tell, but it would be great to hear from people who have almost no 2d6 to hear about their experiments with high codeine dose...
Can anyone think of any concerns?
Obviously liver and kidneys cop a beating, but I've had them tested recently and all is fine. so far.
Histamine reaction has never been an issue for me, I've not been itchy/etc. There's certainly no chance of respiration failure.. 750ish mg doesn't get me high anymore so much as it brings my stress down to half the level it would otherwise be at. It looks like alot when put in writing but it's only a 25% increase.
OK I've been doing codeine a long time.... 8 years now? 9? The first few are a blur. I gather I'm one of the lucky ones in terms of metabolism into morphine.
Anyhow, past experience led me to believe there was a ceiling dose to codeine. From what I've read it varied widely, mine seemed to kick in somewhere between 400 - 500 mg. To give you an idea of my conversion rate at the point I was taking 500mg doses of codeine I had to take 80mg oxycodone (no time release) to get to the same place. This isnt an exact comparison due to the difference in feeling, but close enough to give an idea. In neither case was I anywhere near nodding, which I used to do (only in the beginning, and rarely) at just 150-200mg codeine.
I started pushing my dose over time up to a little further than 500ish as my tolerance built, not achieving any enjoyable gains, but noticing a slight improvement up to about 700mg. It was never really 'worth' upping the dose beyond what I thought was the ceiling, but you know.. any tiny gain.
Needless to say at this point I was doing the most efficient CWEs humanly possible.
Now as I understand the metabolism of codeine to morphine is inhibited by morphine itself, but codeine-6-glucuronide which (may) has/have a very mild analgesic/euphoric effect is still metabolised. Or at least this was what people proposed from my readings.
In the neverending quest to get high like the old days, I've started to wonder if it's possible to take a high enough codeine doseage to push the codeine-6-glucuronide levels up to a level that will actually have a strong impact.
Just wondering what people's personal experience with the so called 'ceiling' dose of codeine are - in general and particularly if you've experimented with going way beyond it. My first experiment is 1000mg, minus loss through inneficiency, which - conservatively - I'd say would be no more than 10%, probably more like ~5.
Unfortunately nobody really knows to be able to tell, but it would be great to hear from people who have almost no 2d6 to hear about their experiments with high codeine dose...
Can anyone think of any concerns?
Obviously liver and kidneys cop a beating, but I've had them tested recently and all is fine. so far.
Histamine reaction has never been an issue for me, I've not been itchy/etc. There's certainly no chance of respiration failure.. 750ish mg doesn't get me high anymore so much as it brings my stress down to half the level it would otherwise be at. It looks like alot when put in writing but it's only a 25% increase.