Opioids Relistor (MethylNaltrexone PNS 'non-CNS-blocking') for OIC -1st hand exp anyone?

[eng55]

Hi guys,

I recently was scripted Relistor, and 1. i am scared to death of it, and was wondering if anyone opiate dependent (ie: bupe anyone?) has tried this injection laxative. I was kind of taken by surprised when my doc just scripted it with less scrutiny than, say, Diclofenac...

First hand experience anyone please? Search engine says 1 guy claims he did go into a PWD for short 15mins and leads claims to the whole 'like loperamide in reverse' debate about the BBB. I figure I better get some bluelight expertise first Thx guys.

 

[cj]

I wanted to try it one time but it's really expensive. Have you tried amitiza and or linzess? My gastro doc used those as first line treatment for my bupe induced backups. They work well along with a change in diet away from diary products.

 

[eng55]

was just thinking of changing away from diary myself... will give that a try, thx..

funny enough, i showed my doc the 'prescriber information Amitiza' page and Dr basically refused to look at phone... instead Dr went away, pulled out an article from a website that gives 'continuing education credits' uptodate dot co... (LOL.... up-to-date.... right...) and Dr printed it out and proceeded to show me the 'latest' options.... (none of which even mentioned Amitiza... & included such valuable suggestions / trials as .... '[therapy line 01:] find patient a discreet & private place to defecate' ... so I hit a brick wall trying to get a pill for OIC, yet I am given a syringe SQ inj medications without knowing how to use it, like its skittles.

 

[Hammilton]

Are you a man? Amitiza hasn't been shown effective in men

 

[cj]

Are you a man? Amitiza hasn't been shown effective in men

Really? That's interesting I am a man. Huh I switched to linzess months ago but that's good to know.

 

[Jktm]

I'm not sure about Relistor, but Naloxegol is coming down the AstraZeneca pipeline and has been for a while. It should be wrapping up Stage 3 trials and shows great efficacy. It's not available as of yet, though. I would guess that it's wrapping up considering they're advertising for the study on TV now. I was part of the study a few years ago. It's µ-antagonism is limited to the GI tract as it doesn't cross the BBB.