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Relieving CB2 Receptor Agonist Withdrawal

down508

down508

Bluelighter
Joined
Dec 25, 2008
Messages
776
Location
Massachusetts
So I have been vaping about 2 grams of 5f-ur-144 a week and due to not properly planning ahead I ran out the night before last. As you can imagine I have been suffering from unbearable withdrawals. Last night was the worst, was constantly vomiting up dark fluids. Having serious difficulty so I decided to grab a bag of store bought blends. It is clear to me that this particular blend contained only cb1 agonists, and instead of relieving the withdrawal it only made it worse. Ordered more today but it won't get here til the day after tomorrow due to not ordering before 3pm. I have never suffered such severe withdrawal. I feel like it has caused a lot of acid reflux, and when I burp it causes vomitting.

Anyways, what I'm wondering is if anybody knows any particular methods that might make me feel better. I am on probation tests and therefore cannot consume any benzos or anything. I am on suboxone, and from what I've read/experienced concurrent use of suboxone with synthetic cannabanoids leads to even worse gastrointestinal problems.

I slept for an hour this morning and after waking up my symptoms have improved, atleast as far as nausea and vomiting are concerned, but I can feel it creeping back up and would literally do anything to avoid going through what I went through last night.

If there are any otc meds that have cb2 receptor activity, or anyhing tha you think would make these couple days more bearable. I want to stop so bad, I've came off heroin habits in the past, and I never got as sick as I got last night. please help.

and feel free to move if inappropriate location.
 
I've been where you are, AM-2201 withdrawals were just as bad as you described. Unfortunately, there really isn't anything you can do if you don't have benzos to sleep it off. Coming from a guy who once spent 10 hours straight picking lint that kindasorta looked like it may have had some AM-2201 powder out of the carpet.
 
I feel like with the magnitude of the withdrawal symptoms there is a huge market for a long lasting partial agonist. If they could come up with a chemical that fills the receptors kind of like suboxone or methadone does for opiates.

Maybe instead of trying to find new increasingly potent cannabinoids to hawk for 6 months before new legislature, they should focus on finding ways to help their customers get healthy.
 
down508 said:
I feel like with the magnitude of the withdrawal symptoms there is a huge market for a long lasting partial agonist. If they could come up with a chemical that fills the receptors kind of like suboxone or methadone does for opiates.

Maybe instead of trying to find new increasingly potent cannabinoids to hawk for 6 months before new legislature, they should focus on finding ways to help their customers get healthy.
Click to expand...

Meh, the intensity is what I liked about AM-2201. The rushy anxiety you get from vaping a decent amount of powder was what I liked about it. I never full out panicked from it though.
 
Well you could always much down on a few multivitamins, some polyunsaturated fatty acids, and extremely dark chocolate to boost endocannibanoid production.
Antihistamines are pretty ballin' at killing nausea and whatever inflammatory firestorm is raging in your colon.
Also, acetaminophen? It metabolizes into a CB2 agonist, but of unknown potency.

Best of luck!
 
I'm thinking about trying actaminophen. Today was a drastic improvement. I'm getting pissed at the vendor for dragging his feet though lol. apparently he doesn't understand the sense of urgency :).

that shit annoys me though. These vendors are so into deleting records that I've probably sent the same info 5 times in the past 3 days. And to top it off he sealed the envelop and then asked me what I wanted. LOL
 
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Excercise, good diet & time are going to be your best weapons in the fight against CB withdrawal. Using other agonist-drugs is probably a shitty plan.

Acetaminophen metabolises into some sort of wacky FAAH inhibitor, I thought. But I don't think it will help you when it comes to CB withdrawal.

It's not like W/D will kill you, just load up on antinauseants.

Ironically the best CB1/2 partial agonist for your situation may be e.g. THC/CBD/CBN (pick one).
 
That's interesting. Clove oil sounds like it could be a good source, since most of the other components are acidic and could probably be washed out with aqueous hydroxide.
 
skillet said:
That's interesting. Clove oil sounds like it could be a good source, since most of the other components are acidic and could probably be washed out with aqueous hydroxide.
Click to expand...
If there any chance that strong base will f**k up this terpene structure?
 
down508 said:
So I have been vaping about 2 grams of 5f-ur-144 a week and due to not properly planning ahead I ran out the night before last. As you can imagine I have been suffering from unbearable withdrawals. Last night was the worst, was constantly vomiting up dark fluids. Having serious difficulty so I decided to grab a bag of store bought blends. It is clear to me that this particular blend contained only cb1 agonists, and instead of relieving the withdrawal it only made it worse. Ordered more today but it won't get here til the day after tomorrow due to not ordering before 3pm. I have never suffered such severe withdrawal. I feel like it has caused a lot of acid reflux, and when I burp it causes vomitting.

Anyways, what I'm wondering is if anybody knows any particular methods that might make me feel better. I am on probation tests and therefore cannot consume any benzos or anything. I am on suboxone, and from what I've read/experienced concurrent use of suboxone with synthetic cannabanoids leads to even worse gastrointestinal problems.

I slept for an hour this morning and after waking up my symptoms have improved, atleast as far as nausea and vomiting are concerned, but I can feel it creeping back up and would literally do anything to avoid going through what I went through last night.

If there are any otc meds that have cb2 receptor activity, or anyhing tha you think would make these couple days more bearable. I want to stop so bad, I've came off heroin habits in the past, and I never got as sick as I got last night. please help.

and feel free to move if inappropriate location.
Click to expand...

I would genuinely recommend cannabis to you... Unless you are holding off because of a drug test, the whole spectrum of cannabinoids in actual weed will probably make you feel a lot better.
 
Clove oil is a shitty shitty source of "clean" caryophyllene, because the eugenol is so pungent and irritating and has a ridiculously low limit of detection.
The commercial "pure" caryophyllene I have seen is like 80-90% (balance is other terpenes) with a 0.1% eugenol impurity, but it still smells very strongly of cloves. I assume it's fractionally distilled.

The terpenes in general are fairly inert hydrocarbons, they don't dissolve well in water.
Washing with basic MeOH and partitioning into hexanes may work as a way of seperating it. No idea if eugenol forms a phenoxide.
It would also be (in theory) possible to purify the compound by thiourea complex.

An even better idea would to source hops oil, or steam-distill some yourself. I asuume hop oil would be closest, excluding true cannabinoids.
 
Not so sure about hops, check out this GC. Peak 11 is caryophyllene...

With clove oil, everything else is acidic (except eugenol acetate, which will hydrolyse to eugenol). I meant to wash the oil several times with aqueous hydroxide, all the eugenol and other stuff will dissolve in the water, leaving just the caryophyllene as oil.
 
Considering myrcene won't hurt anything, & humulene is isomeric to caryophyllene, I still think hops would be superior in terms of taste/palatability.

Perhaps I will try washing some "technical" caryophyllene with base & report. I think the detection limit of eugenol is too low & its just not acidic enough
 
If you gel-cap it, traces of eugenol aren't going to matter. It's plenty acidic, standard work-up for phenol methylations is to wash with 10% or so NaOH to remove unreacted phenol.
 
Horrible development? More like obvious. Who ever thought that smoking grams of highly potent agonists in short spans of time was a good idea?
 
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