blueberries
Bluelighter
- Joined
- Jan 13, 2011
- Messages
- 339
Ok,
I've forever been puzzled by this and need a proper answer without the shit surrounding it. I have UTFSE and I've had multiple answers (also it's pretty difficult to search for!). So basically: "Can you use neurotransmitter releasers and reuptake inhibitors together?".
I've always believed that you cannot as they would both cancel each other out. However recently I've come to see that they can, even enhancing each other (which would be the most logical conclusion, however logic doesn't seem to apply when it comes to neuroscience!). Compounds such as the APB's and APDB's utilise both releasing mechanisms and reuptake inhibition. At the end of the day though, if each were to potentiate each other, wouldn't they be more potent than straight releasers like MDMA and MDA? Or is the reason they have similar potencies due to the agonism that MDx provide (which the APx's make up for with reuptake inhibition)?
So what is the real answer? I'm on both a releaser and a reuptake inhibitor at the moment (speed and 3F-phenmetrazine) and they seem to be syncing pretty well but is there any danger of losing activity (or gaining for that matter)?
I've forever been puzzled by this and need a proper answer without the shit surrounding it. I have UTFSE and I've had multiple answers (also it's pretty difficult to search for!). So basically: "Can you use neurotransmitter releasers and reuptake inhibitors together?".
I've always believed that you cannot as they would both cancel each other out. However recently I've come to see that they can, even enhancing each other (which would be the most logical conclusion, however logic doesn't seem to apply when it comes to neuroscience!). Compounds such as the APB's and APDB's utilise both releasing mechanisms and reuptake inhibition. At the end of the day though, if each were to potentiate each other, wouldn't they be more potent than straight releasers like MDMA and MDA? Or is the reason they have similar potencies due to the agonism that MDx provide (which the APx's make up for with reuptake inhibition)?
So what is the real answer? I'm on both a releaser and a reuptake inhibitor at the moment (speed and 3F-phenmetrazine) and they seem to be syncing pretty well but is there any danger of losing activity (or gaining for that matter)?