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Regarding Possible Cross-Tolerance vis-a-vis 25D-NBOMe

lamanogaucha

Bluelighter
Joined
Feb 4, 2012
Messages
583
Hello,

This is my first "real" post on Bluelight, so I hope that I have posted it in the appropriate place. If not, please feel free to place it in the correct location.

I have resided and worked in China since early last decade. During that time, I saved some money to "retire" for a long period of time in order to engage on a long-term project involving psychedelics, a handful of empathogens and a tiny handful of stimulants. I now have the means, opportunity and time to do so. The project's ultimate goal is to see publication of a book regarding the subject of "research chemicals" -- my experiences with said materials, summary personal observations on each compound, and whatever pertinent information that may be useful to those interested in the subject, novice and experienced alike. I estimate that the project will take between three and five years to complete, as I have assembled and properly stored a collection of nearly thirty compounds to explore (and probably a few more will be added). Nearly all of these are (and will always remain) psychedelics, including phenethylamines, tryptamines and dissociatives (the focus falls strongly on the first two, and at approximately equal ratios, however). Each material will be tested between five and ten times, usually in increasing doses and occasionally repeating a "level" if deemed necessary or if exploring a different ROA. Please keep in mind that I drink alcohol only three or four times a year (and never less than at least two months prior to a psychedelic experiment) and I stopped using cannabis years ago (and have never used cannabinoids). I am under no medication whatsoever, but I do take multivitamin supplements daily. This has been the case for many years. However, I do smoke tobacco -- approximately three-quarters of a pack of unfiltered cigarettes daily for over twenty years. I really must quit, but I love to smoke, sad to say, while the PRC is not exactly the best place to give up that addiction...

During the last two months, I explored the first compound of the project: 4-AcO-DiPT (HCl). This was executed at the following dosages (via oral ROA): 15mg, 20mg, 25mg, 30mg, 30mg, 30mg, 32mg, and 15mg. I experienced very little to no tolerance issues with all but one of these experiments, all of which were extremely enjoyable, even if another one was slightly spoiled during the second half due to some neighbors believing that it's fine to bring roosters into their respective apartments and allowing them to scream continuously through the night ("cultural difference", mainland China style; on the other hand, it is a blessing to live in a country where all of the project's materials are, paradoxically, legal, as I've dutifully confirmed via current government documents written in Mandarin).

I followed the above experiments with 25D-NBOMe, a sharply contrasting compound. The ROA was buccal and the initial dose was 1.2mg. Feeling rather underwhelmed one hour after the forty-five minute saliva festival I had to endure (I held the eventually massive amount of gooey, bitter liquid in my mouth that entire time prior to swallowing it slowly, blotters and all), I ingested an additional 400ug (which was kept in its rightful place for about thirty minutes). The theoretical total was now 1.6mg and the time was T+2.25. Primary psychedelic effects gradually became somewhat more apparent but by T+3.25, I was still "not there", so I consumed an additional 800ug over a second thirty minute period. The theoretical total was now 2.4mg, a substantial dose, and the time was T+3.75. This eventually brought me to the edge of "there", but not quite. All the same, the experience was pleasant, albeit in a rather analytical way, and there was no body load throughout its total duration, which was approximately nine hours.

I understand that this compound -- and 25x-NBOMe's in general -- can produce rapid tolerance toward itself, but I suspect that tolerance accumulation is extreme with this material, as 2.4mg should have virtually floored me. It seems that this compound demands that a psychonaut ingest the total dose immediately or nothing at all.

I also suspect that cross-tolerance may be an issue in view that my final test with 4-AcO-DiPT (at 15mg) was conducted a scant two days prior to my first 25D-NBOMe experiment. This leads to several questions:

1) Can 4-AcO-DiPT (and/or any other tryptamines, particularly the 4- and 5-substituted compounds) taken prior to 25D-NBOMe (and/or any other NBOMe's, particularly the 25x compounds) cause cross-tolerance problems? If so, how long, on average, should one wait between the two experiments?

2) Can 25D-NBOMe (and/or any other NBOMe's, particularly the 25x compounds) taken prior to 4-AcO-DiPT (and/or any other tryptamines, particularly the 4- and 5-substituted compounds) cause cross-tolerance problems? If so, how long, on average, should one wait between the two experiments?

3) Closely related to the above, I understand that one should wait approximately two weeks between 25D-NBOMe trials (and the same applies to 25x-NBOMe's in general), but does this rule also apply in the case of 25D-NBOMe vis-a-vis other psychedelics?

This information is important to me because I want to schedule 25x-NBOMe's very carefully, so as not to accidentally have them interfere with other compounds. Likewise, I want to insure that other compounds don't interfere with 25x-NBOMe's.

I'm looking forward to your responses. Thanks.
 
Wow, that's one impressive project you have there!

I'd say that all psychedelics (regardless of their molecular structure) cause tolerance to themselves and cross-tolerance to each other.
It seems to me that the time needed to get rid of (cross-)tolerancies correlates (though not perfectly) with the time of duration. So N,N-DMT-tolerance dimishes quickly (next day works as good as the day before), 4-HO-DMT-tolance needs about 7 days, LSD about the same (perhaps a tad longer) and 25C-BOMamine effects were dimished even after 10 days.
These observations and numbers are of course subject to personal variation and set&setting.
My (subjective) answers would be:
1) Yes, the effects can be diminished if taken within less than 7 days.
2) Yes, the effects can be diminished if taken within less than about 14 days.
3) Yes, the effects can be diminished if taken within less than about 14 days; moreover it seems to me that 25x-BOMamine-tolerance is more effective than the others'

It may prove useful for you to switch to nasal application with 25x-BOMamines. I can report of a peculiar instance where 360 µg of the chloro-derivative insufflated were a lot stronger than .8 mg and 1.2 mg in blotters (mushed up with water and plugged).

Hope you get more influx, as your project could generate a lot of very useful information for the community. Though a printed publication may not appeal to everyone, but this is not to discuss here.
 
how much more nbome would one need to get the same effects if one would not wait the time needed for tolerance to go away... 2x? 3x?
 
I found a cross-tolerance between 25C-NBOMe and 4-HO-MET was still very present at one week. I waited 2 weeks without any psychedelics before I took 750 micrograms of 25C-NBOMe buccally. This combined with cannabis brought me to a strong +3 on the Shulgin scale. Exactly one week later I took 25mg of 4-HO-MET orally, which is my normal dose. This will usually take me into a strong +3. But, the cross-tolerance was very evident. I might have bordered on a +2/+3 at the peak. It's only been a week since then, and I don't have any plans on experimenting for another couple weeks. I want to try to let all tolerance disappear.
 
Based on sn23's and Redbong's posts, one can conclude that an interval of 7-14 days is essential when a 25x-NBOMe compound is involved. I'll stick to waiting two weeks in all cases involving 25x-NBOMe's, whether on their own or following/preceding anything else. This is a bit of a "flaw" with 25x-NBOMe's, in my opinion. I prefer intervals of 4-10 days, my average being one week.

Regarding switching from buccal to insufflation, I'm planning on doing just that with all 25x-NBOMe compounds. I will only perform one more buccal trial with 25D-NBOMe at 1.6mg. After that, I'll stick to solution/insufflation for all like compounds and adjust dosages accordingly.

Thank you for your posts, guys.
 
Please be advised that other routes of administration may have somewhat different (side)effects, this is true for some compounds more than others. It is not clear to me yet how true this is for NBOMe compounds, I have had too few trials myself, but it seems like a lot of material can be lost with buccal or sublingual administration depending on how it is done, while nasal administration can be more powerful. That is, if you make sure to avoid drip. I have only tried 25C and 25D in limited quantities but found 25D to be quite stimulating in a weird way. I felt a pressure on my chest and a lot of coldness in my feet. I may have a bit weak circulation to begin with.
If you will be trying to compare these compounds and the ways they are administered, make sure tolerance from other compounds or cross-tolerance does not get in the way, at least not more than is feasable.

Please use the Psychedelic Index to find the link to the N-benzylated / N-arylated superpotent compounds that include the NBOMe's. If you have more questions I suggest you ask them in the general thread there or in the single-compound focus threads.
Also check the Beginners FAQ if you would like a little help finding your way around.

If there is a more specific topic you think that needs its own thread here let us know what your other questions are otherwise we can close this. :)

(links are in my signature)
 
Thank you for the information, Solipsis.

It's funny that you mentioned poor circulation because I also have that problem, almost exclusively focused on my feet, and especially in winter. I didn't experience cold feet with this compound though. Actually, I experienced no negative side effects at all, aside from extreme tolerance accumulation.

I started this thread separately from its dedicated thread(s) because my questions were mostly regarding the compound's tolerance relationship with other compounds. However, in hindsight, it may have been better to locate my posts in a dedicated thread. Feel free to close this one, as my questions have already been satisfactorily answered. Cheers.
 
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