reducing toxicity of amphetamines with delayed admin of methylphenidate

[janestadler5]

I read about 2 years ago that it has been shown in rats that administering methylphenidate (or other reuptake blockers) up to 8 hours after the methamphetamine will greatly reduce the toxicity of methamphetamine. I wondered if anyone had tried this, and what their experience was. --Did the methylphenidate reduce the nasty after effects of methamphetamine or other amphetamines??

 

[pasha]

welcome to bluelight. promising op, but it would be nice if you could link your source. "i read something 2 years ago so lets discuss it" doesn't exactly seem credible. i will give you the benefit of the doubt.

homeless -> other drugs

 

[janestadler5]

Here is one cite:Methylphenidate Alters Vesicular Monoamine Transport and
Prevents Methamphetamine-Induced Dopaminergic Deficits
VERONICA SANDOVAL, EVAN L. RIDDLE, GLEN R. HANSON, and ANNETTE E. FLECKENSTEIN ´
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah
Received October 3, 2002; accepted December 4, 2002

 

[janestadler5]

Here is another cite: Marek GJ, Vosmer G, and Seiden LS (1990) Dopamine uptake inhibitors block
long-term neurotoxic effects of methamphetamine upon dopaminergic neurons.
Brain Res 513:274–279.

 

[MakaveliTheDon]

Not sure entirely, but i think that MPH has the worst comedown of every stim way worse than amphetamines definetly lmao. i was withdrawing last part of yesterday and it is just as if not more uncomfortable than a full-blown xanax withdrawal. you feel sick, suicidal, guilty, out of energy. its the only stimulant that brought back the temperature sensitivity w/d effect that i had when tapering off xanax , and god ill tell you that is hell, feeling the burning hot or ice cold air pierce your nerves and put them into sensitive overdrive.

 

[Ksa]

I couldn't read the paper because I don't have access to it but I did read the abstract. From what I understood of the activity of Ritalin...it's more adequate to be given after a methamphetamine overdose or near overdose. Not sure if it works for chronic low doses of methamphetamine. Also, don't expect a huge high when taking Ritalin to counter a huge methamphetamine comedown, from what I read it about its effects it sounds quite painful, its effects.

Not sure entirely, but i think that MPH has the worst comedown of every stim way worse than amphetamines definetly lmao. i was withdrawing last part of yesterday and it is just as if not more uncomfortable than a full-blown xanax withdrawal. you feel sick, suicidal, guilty, out of energy. its the only stimulant that brought back the temperature sensitivity w/d effect that i had when tapering off xanax , and god ill tell you that is hell, feeling the burning hot or ice cold air pierce your nerves and put them into sensitive overdrive.

Abstain from useless comments, taking a given dose of Ritalin to counter methamphetamine comedown is not the same as Ritalin crash.

 

[Hecticus]

What would this therapeutic dose of methylphenidate be? And are you able to substitute with any NDRI? I have Ethylphenidate.
Also who realistically does 1 dose of meth (as shown in the study), i'd assume this wouldnt make any difference if binging. Worth a try though.