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[Rectify]

BRITNEY
1-methyl-3,5-dicarbomethoxy-4-(phenoxy)1-azacyclohexane

 

[Rectify]

SEZZLER
1-methyl-3-carbomethoxy-4-((3,4-methylenedioxyphenyl)methanoneyl)-azacyclohexane

 

[Rectify]

O'CHARLEY
1-methyl-3-carbomethoxy-4-phenylmethanoneyl-azacyclohexane

Possibly From Arecoline.

 

[Smyth2]

Pavettine to tranylcypromine analog.

https://journals.co.za/doi/pdf/10.10520/AJA03794350_1994

 

[MedicinalUser247]

That reminds me of this. https://ibb.co/mCYGKQNC

 

[Rectify]

That reminds me of this. https://ibb.co/mCYGKQNC

The Pyridinyl Ring Needs Reduction To A Piperidinyl One To Retain Activity Most Likely.

 

[Rectify]

Just Ran Across This Jam Today.

 

[Smyth2]

The Pyridinyl Ring Needs Reduction To A Piperidinyl One To Retain Activity Most Likely.

That's an interesting observation but i know of places where the pyridine ring is used for a source of nitrogen.

Cyprolidol, Linopirdine, DMP 543, XE 991 for example.

 

[Rectify]

THE_MIND_BENDER
N-ethyl-lysergamide

 

[Rectify]

Smyth2,

How About This One?

PARKERS
1-phenyl-1-carbomethoxy-1-(2-pyridinyl)methane

 

[MedicinalUser247]

Smyth2,

How About This One?

PARKERS
1-phenyl-1-carbomethoxy-1-(2-pyridinyl)methane

That almost looks like Methylphenidate, but you have the Ketone faced in the direction where it would feel more like Coke.

 

[MedicinalUser247]

Draw it the correct way and post it then, u

It's on Wikipedia already. I don't need to post it.

 

[Deleted member 545227]

It's on Wikipedia already. I don't need to post it.

Link?

 

[MedicinalUser247]

https://en.wikipedia.org/wiki/Methylphenidate

 

[Rectify]

No, it is methylphenidate with a pyridinyl ring instead of a piperidine ring. Look again.

 

[Rectify]

BLUE_LIGHTNING
1-(3,4-methylenedioxyphenyl)-1-carbomethoxy-2-methylaminopropane

On Paper Anyway, I Would Be Surprised If This Molecule Isn't Good. It Has Everything Going For It.

 

[Rectify]

A Possible Synthetic Pathway For Blue Lightning:

SAFROLE
1-allyl-3,4-methylenedioxy-benzene

Step 1: The Wacker Oxidation

1-(3,4-methylenedioxyphenyl)-2-oxopropane

Step 2: Piperonyl Bromination Using Br2

1-(3,4-methylenedioxyphenyl)-2-oxo-1-bromopropane

Step 3: Protect Carbonyl With Ethylene Glycol Under Non Acidic Conditions

Step 4: R-Br --> R-CN, Then Step 5, Deprotect With H+.

1-(3,4-methylenedioxyphenyl)-2-oxo-1-cyanopropane

Step 6: Reductive Amination Of The Ketone Intermediate

1-(3,4-methylenedioxyphenyl)-2-methylamino-1-cyanopropane

Step 7: R-CN --> R-(C=O)-O-CH3 With Chloro Trimethyl Silane

BLUE_LIGHTNING
1-(3,4-methylenedioxyphenyl)-2-methylamino-1-carbomethoxypropane

 

[Rectify]

Bounce From P2P, A Theoretical Synthetic Outline:

Don't Have Ephedrine? Use P2P!

P2P
1-phenyl-2-oxopropane

Br2 -->

1-phenyl-2-oxo-1-bromopropane

Protect The Carbonyl With Ethylene Glycol HO-CH2CH2-OH --> Then Use KCN --> Then Deprotect With H+ -->

1-phenyl-2-oxo-1-cyanopropane

Reductive Amination -->

1-phenyl-1-cyano-2-methylaminopropane

Then Chloro Trimethyl Silane -->

BOUNCE
1-phenyl-1-carbomethoxy-2-methylaminopropane

 

[Rectify]

2-methanoneylnaphthalene

(Go Buy PiHKAL! Read It.)
-->

1) NaBH4, CH3OH
2) Sn /HCl

SUCRETS
2-(2-aminopropane-1-yl)naphthalene

 

[Rectify]