N&PD Moderators: Skorpio
You should upgrade or use an alternative browser.๐๐ Social ๐๐ Rectify's molecular poetry thread
aspiringdrugdesign
Bluelighter
The least you could do is edit your previous posts and compile all these molecules that have little to no chance of doing anything into one post of schizotypal behavioraspiringdrugdesign
Bluelighter
pharmakos
Bluelighter
Limpet_Chicken
Bluelighter
I am surprised you got away with it for as long as you did. Keep it to a journal or something.sekio
Bluelight Crew
I am not famous, but please look if you can see my molecules
(Note; i am not a fan of phenehtylamines and tryptamines, im more of a โbinoids type)Limpet_Chicken
Bluelighter
To bring some intelligent debate into this otherwise shit-filled mire; have psi-DOC or psi-DOI/psi-DOB been tested?sekio
Bluelight Crew
Nichols looked at the psi-3CD-FLY/DFLY compounds [ref] and sez that PSI-DOM is about 1/3 the binding affinity than DOM at 5ht2a.Dresden
Bluelighter
Ok, but 1st, let me ask, do you like to drink alcohol or not really? I've got 2 in mind, but answering that question will settle the decision for me!
I ran into
LOGAN MICHAEL REESE JUSTIN TIMBERLAKE
this AM @ Wal-Mart. He's a great guy!
AMP
POMZAZED
This one's a *bit* of a gamble, but hey, no guts, no glory, right?!Limpet_Chicken
Bluelighter
Pomzazed-do you mean the molecule that idiot 'discovered' with his speshul magical fairy ability to sense vibrations and determine a person's 'spirit molecule', you know, as a special magical indigo child, might have some bioactivity of interest?
I think dresden's magic indigo child 'talent' is washing off on me.
I can sense it! I can sense his airy fairy magical unicorn spirit-molecule.
C4H4AsH, the carbon and hydrogen atoms prior to the heteroatom arranged in a ring structure otherwise identical to pyrrole, with a pair of double bonds between the 2,3 position and between the 4,5-position, the terminal H is attached directly to the heteroatom.
(I'm wondering if by giving this description, this so-called 'chemist' who can see special vibrations in people because of his fwuffy-wuffy majick in-dee-goh child special status will get it, or whether as I predict, his special talents will utterly desert him, without his reading the manual for chemdraw or something then using wikipedia.)Limpet_Chicken
Bluelighter
Sorry, most of us here are western, and don't go around eating seal blubber for a snack.Dresden
Bluelighter
Limpet_Chicken
Bluelighter
Or do you do it all by magic? Sorry but make claims like that and you, given your prior activity have to be called out on that.
I for one, reckon you are talking shite. And established drug designer? go on? for who? because I think you are lying.
'established drug designer' doesn't mean some idiot drawing random rubbish and giving it airy fairy names, and in plenty of cases ripping off the work of Sasha Shulgin (for fucks sake! Shulgin! you are one tasteless piece of odious garbage to do that!) and giving it a new name what with your special magic powers and that.
It means someone who goes to work, studies molecules and how they may interact with clinical targets, much of the time running screenings of a great many permutations of molecules, and thousands of tiny chemical variations on such a base molecule possible drug candidate for some purpose, and then doing so for the next molecule in a huge set, along with all the 'replace this hydrogen with fluorine, change a chalcogen or halogen here, lengthen or shorten THIS alkyl group, change an ester for an ether for a thioether for a......'
And using molecular modelling software, using it to pick your candidates based on steric, van der waals, salt-bridge, halogen bonding,hydrogen bonding etc. interactions and how docking a molecule with the protein target may alter the 3D conformation of the protein, giving the drug-protein complex a whole new lot of studies needing to be calculated in energy-minimized conformation.
And of course there are the 'orbitals are for mathematicians, chemistry is for those who love to COOK!' actual real chemists. Those who are smart, intelligent, but don't work for big pharma. You are neither. You. Are. Garbage. And a liar.Limpet_Chicken
Bluelighter
Go on then. Prove it. What have you designed. What field of work are you in. What qualifications have you got relevant to such a career? (no, 'magic' does NOT count)
Prove to us you are really what you say you are. Because this thread could really benefit with a real pharmaceutical chemist's input to clean it up, foster intellectual discourse, because some foolish little twat started it, unfortunately, and worse it wasn't stamped down by the mods as the garbage it is.
A real pharmaceutical chemist, an expert, ESTABLISHED genius chemist, I'm sure they could turn this travesty of a thread around and start some intellectual discourse, to help make something of this thread, rather than for some insufferable and logic-devoid reason, the mods providing a bucket for somebody to vomit in.
Jesus fucking christ. Thank fuck! thank FUCK we now have our own established drug designer, maybe their qualifications will help us turn this from a fucking bucket full of spasmodically beshitten cretinous gastrointestinal trash, into something people could read and not only not want to drop the OP into a vat of acid, but even CONTRIBUTE to.