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Rectal 4-FMP administration

Xorkoth

Xorkoth

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I decided to post this here because everywhere else I've been asking, no one has a clue. If it's inappropriate, feel free to move or close it.

I have a hunch that no one has tried rectal administration of 4-FMP (4-FA, 4-fluoroamphetamine) because it's a pretty rare substance. However, I know from experience that plugging regular amphetamines reduces the dose needed and in general is a good idea. Does anyone have any theories about how plugged 4-FMP would work? Any thoughts based on similar substance knowledge that might indicate about how MUCH reduced the dose would be? Anyone actually have experience with this?

Any thoughts are appreciated. Thanks! My issue is that I only have 150mg and my regular oral dose is 125mg. I'm kinde of hoping that 75mg rectally might be something like 125mg orally, which would give me two doses instead of one.
 
You'll probably get a really strong rush. Wish I had some to try it! ;) As for the dose, I can't really tell you as I'm not experienced in using drugs that route.
 
Generally you get away with a smaller rectal dose of an amphetamine compared with the oral route, but it really does differ from one drug to the next depending on the degree of 1st pass metabolism. You get a bit more of an effect with plain ol' amphetamine, but with something like DOC all it does is alter the speed of onset.

You'll get more of a 'rush' from rectal use, but that isn't always a good thing (esp with full blown psychedelics). I'm afraid that you may have to be the one to find out for everybody else...
 
^Eh, how? The fact that 4-bromoamphetamine is highly neurotoxic is one of those things that indicates you shouldn't go anywhere near any amphetamine with a single halogen atom (other than fluorine) substituted anywhere into the aromatic ring
 
Eh, I don't get it... personally I love 4-FMP/4-FA. It's very warm and lovey like MDMA, only for me, it's a better high than MDMA because it lasts longer and it's less "fake" feeling. Plus it leaves me feeling fresh and chipper the next morning.

I tried 80mg rectally last night and it was as powerful but "rushier" than 125-150mg orally. The euphoria was quite profound for the first three hours, much more profound than any MDMA I've had in years. Then again, I don't really respond well to MDMA anymore.

I also added 11mg of rectal 2C-D to the mix at T+3 hours which added a nice aspect to the high and reduced a number of the emerging amphetamine peripheral side effects, and got rid of the "lossy" feeling I was starting to feel as the euphoria wore off. At T+4 or so, I drank some kratom and the mixture of the 3 was truly enjoyable in every way. I had no problems sleeping at T+6 or 7.

The desire to repeat the experience is strong. Fortunately I only have 70mg left and no more in the forseeable future.
 
Sounds like a very interesting drug.

I have done a few stimulants rectally in the past. The rush is amazing even from plain things like methylphenidate.
 
Actually I looked into the Rothmann paper and 4-F- and 3-F- were self-administered both to about the same extent (which was good) whereas 3-Me and 4-Me and naphthyl analogs were all crap, particularly that last one. Thus to some extent you can get away with some 5HT activitity in a DA/NE releaser but if the ratios get too close to unity then you get something that loses its abuse potential.
 
I would definately stay away from any 3- or 4-alkyl or halo (other than F) substituted amphetamine. The examples set by p-chloro-amphetamine (PCA), fenfluramine, PMA and PTA are enough to scare me away from these compounds.
 
^^^I agree.

4-FA is somewhere in between amphetamine and MDMA for me, in terms of the qualitative nature of the experience. I've plugged MDMA, MDA, amphetamine, methamphetamine, 4-MAR, but not 4-FA. Judging from my experience, I think most monoamine-releasing compounds have a similar relative increase in "rushiness" (which I believe is directly related to the speed with which it hits your brain) and potency with rectal administration.
 
I've only had it orally, and onlyonce, but I also think it's a wonderful drug that I would like to have more of at an affordable price. right inbetween speed and mdma indeed :D
 
I take-back what I said about p-FA as it looks aesthetically more 'correct' than m-FA regardless of what I read in the paper. On a scientific note though I still feel its important to point out some of the results from that paper.
snips.GIF
 
Kind of off topic but I thought a 1:1 DA/5-HT ratio was associated with reduced self-administration, but this attachment lists PAL-287 (alpha-methyl-naphthylethylamine) as having about a 3.7 ratio.
 
That paper shows that PAL-287 wasn't liked by the rats. 3-fluoroamphetamine is more potent than 4-FA and the rats self-administered it more...
 
fryingsquirrel said:
How long for full affects rectally? For meth, in particular.
Click to expand...

Slightly slower than IM injection for most stimulants I've found ie 10-15 mins to get the 'full flavour' of the drug. Needless to say, but I'll repeat just in case: if you do this with full blown psychedelics, be careful especially with the phenethylamine compounds (rectal admin of an equal dose of 2C-C turned it from a very friendly, malleable psychedelic to being a white knuckle come-up of the first order. Actually the only severely anxiety ridden time I've ever had with a 2C-x compound)
 
hussness said:
Kind of off topic but I thought a 1:1 DA/5-HT ratio was associated with reduced self-administration, but this attachment lists PAL-287 (alpha-methyl-naphthylethylamine) as having about a 3.7 ratio.
Click to expand...
Mathematically thats correct but its not uncommon to round it down on a qualitative basis. Particularly with something like PAL-313 but with the napthyl analog you are quite right in pointing out that its primary activity is as a serotonergic and not a stimulant.

Relationship between the Serotonergic Activity and Reinforcing Effects of a Series of Amphetamine Analogs.
S. Wee, K. G. Anderson, M. H. Baumann, R. B. Rothman, B. E. Blough, and W. L. Woolverton (2005)
J. Pharmacol. Exp. Ther. 313, 848-854
 
Looks like m-fluoroamphetamine would be an interesting compound, about twice as potent as 4-FMP.
 
Dr.Heckyll said:
Looks like m-fluoroamphetamine would be an interesting compound, about twice as potent as 4-FMP.
Click to expand...

I remember reading somewhere, many moons ago that 3-fluoromethamphetamine is supposed to be a 'what the fuck', monster of a CNS stimulant - even more potent than the parent meth. Sounds like it's just as well that 3-fluoro pseudoephedrine never found any pharmaceutical use or there'd be a crazier drug than meth doing the rounds!
 
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