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Raver serotonin/dopamine MDMA question

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Th3Hamm3rSm1th

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Hey guys, a person I know from around came to me with a query about his serotonin/dopamine levels, they are an experienced user of e based pills and has built a high tolerance, and does not get much buzz from pills anymore. 30 hours ago they ingested a very small dosage (just a few mls) of liquid containing either methylone or butylone, got 4 hours sleep ( 3 hours after ingestion). 16 hours ago they started snorting low quality coke, took about a gram over a 10 hour period, and also ingested two sudafed (60mg tablets containing psuedoephedrine-HCL) tablets 2 hours ago (also they were smoking weed at varied points throughout). They havent taken pills containing e in 2 weeks, and is going to try powder form MDMA for the first time tomorrow night going to a rave (as they do not wish to take ecstacy in pill form anymore, and intends to lay off MDMA altogether for a while after the rave). Their question was will their serotonin and dopamine levels be returned to a point where they may experience a pretty good roll (as the levels will obviously be depleted) with the MDMA (they intend to swallow 250mg in a rizla), and they were also wondering is it true that the first time taking free form MDMA is better than the first time taking pill form MDMA.?
They informed me that they will not be sleeping for another 16 hours or so, and intends to chute the MDMA about 38 hours from now.
 
250mg mdma is a very high single dose ya know???

Also , i personally have found when i do mdma? I like to be fresh and ready for it. The person you know probably should have a little break off it all, even if they are 'hardcore' they are gonna suffer some Psychological effects i'd say.
They havent taken pills containing e in 2 weeks,
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That's not long at all , In fact we recommend you wait a month between taking E at the very least.
 
It will work perfectly, most of your drugs u used dont target serotonin, start with 125-150 mg MDMA.
 
It sounds to me like your friend needs to slow it the hell down. I would be exhausted at this point if I were him. He's been a busy boy :/
 
eLW said:
It will work perfectly, most of your drugs u used dont target serotonin, start with 125-150 mg MDMA.
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A lot of MDMA's affect is actually caused by dopamine..

Methylone and Cocaine both affect 5-ht and DA..
 
Th3Hamm3rSm1th said:
they are an experienced user of e based pills and has built a high tolerance, and does not get much buzz from pills anymore.
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If you don't get much buzz from pills, you won't get much buzz from powder MDMA.

They havent taken pills containing e in 2 weeks,
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2 weeks is not a long enough break. It seems that you've developed a tolerance and are searching for a way to get around it. The only way to do so is to wait at least a month before rolling again, preferably two or three.

(as they do not wish to take ecstacy in pill form anymore,
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Ecstasy in pill form and ecstasy in powder form are the same chemical, MDMA.

and intends to lay off MDMA altogether for a while after the rave).
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Good. Take a break of at least a month.

Their question was will their serotonin and dopamine levels be returned to a point where they may experience a pretty good roll (as the levels will obviously be depleted)
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"Pretty good roll" is pretty vague... But probably not.

is it true that the first time taking free form MDMA is better than the first time taking pill form MDMA.?
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No. Whoever told you that is lying to you. Unless your pills were bad. Did you test your pills with a reagent kit? If the person who sold you the powder MDMA told you that it's "better" or "different" than MDMA in pill form, then that person is lying and you really need a test kit. eztest and dancesafe are good places to look up.
 
Okay.

Entactogens like MDMA, methylone or butylone need to be spaced at least a month or two from each other.

You're essentially setting your body up to need a bigger and bigger dose to feel the same "high" again by overusing these powerful serotonin stimulants. What will result is nothing the high is worth. A larger dose = more side effects.

As for cocaine, it can lead to some dopamine down regulation(Not nearly on the scale as meth abuse), but the biggest concern I have in your mentioning of it is that cocaine weakens the heart quite a bit. MDMA is not exactly that safe for the heart either.

You'll either take our warning or experience the nightmare and mystery of the serotonin drop off. There's not a lot anyone can do about it either.
 
They ended up doing one ecstacy pill, 3 pills containing AMT, some more coke, 2 stamps of some form of slow releasing tripper, and a stamp of LSD. Enough said
 
Th3Hamm3rSm1th said:
They ended up doing one ecstacy pill, 3 pills containing AMT, some more coke, 2 stamps of some form of slow releasing tripper, and a stamp of LSD. Enough said
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Why would you do coke in the middle of that? Coke kills your roll and I can imagine it doesn't synergize with AMT or LSD.
 
Lol you could have enjoyed yourself for a good 3months with that. The aMT even longer.

I would have, anyway. aMT is a tool, not a recreational drug. As is MDMA and LSD. Cocaine is bullshit, around here it is anyway, because no one is near enough to the source to have sth decent. Mostly like 15-20%. My two cents.
 
Achten said:
Lol you could have enjoyed yourself for a good 3months with that. The aMT even longer.

I would have, anyway. aMT is a tool, not a recreational drug. As is MDMA and LSD. Cocaine is bullshit, around here it is anyway, because no one is near enough to the source to have sth decent. Mostly like 15-20%. My two cents.
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At first your opinion seemed very heavy and I was close to disagreeing, but this is actually pretty much what I believe as well.



Moderation Note: The question has been handled quite well here. I advise the OP to spend a few minutes and read around as many of these questions with drug interactions have been answered in very recent threads. Serotonin and Dopamine are specific to the individual. Dopamine with amphetamine type drugs vs. Cocaine is also something which takes a little reading to understand.

I'm going to go ahead and close the thread. Please feel free to contact me or another moderator/administrator with any questions comments or concerns. We don't bite :3
 
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