Rarest drugs you've done?

[4DQSAR]

Lastly, in terms of harm reduction, CuCl/CuCl₂ mixtures generate significant metal waste and are toxic and environmentally persistent. And anyway, the oxygen needed for the reaction process is supplied by the p-benzoquinone or simply O₂ in the original reaction… I wonder how rough the CuCl is on the PdCl₂ in terms of efficiency.

Chemistry undegraduates are uniqely able to have their university dispose of the hazardous side-products. For free.

It's so long ago I don't have any of the papers (written ON paper) any more. But I suggest that cuprous species is in fact a co co-catalyst and is responsible for lowering the enery barrier for the reoxidation of the palladium (I) complex to the (II) complex.

Remember, we did have the resources to analyse the various species. Even today, how do you do it? Have your salts all made from 36Cl or maybe 37Cl and look at where the isotopes go? It would be an immensely costly endevour.

But being as the copper salts were free (given where we were), even if it only halves the qantity of PdCl2, that's a saving.

Yield was - enough.

 

[unodelacosa]

Chemistry undegraduates are uniqely able to have their university dispose of the hazardous side-products. For free.

Well… free to the student, anyway. And while the environment is important, the purpose of this site is harm reduction, so I'm trying to keep it in that scope

But yeah Pd-catalyzed Wacker oxidations can certainly use CuCl₂, as they indeed do. But it's important to carefully control the reaction for the best results. I would process it in batches back then, but using a flow reactor is probably better optimized, easier to handle, provides better control, and splits the reaction into micro-reactions thus limiting liabilitity, reducing risks, and facilitating multivariate testing of the reaction conditions if one wants to fine tune the optimization. I also understand that in legit industry this is easily scaled up.

 

[Tryhard_In_Bed]

Tiletamine, basically magical powdered hole, and aMT flipping dust. miss both of those thoroughly and would like to combine the two one day.

 

[4DQSAR]

Well… free to the student, anyway. And while the environment is important, the purpose of this site is harm reduction, so I'm trying to keep it in that scope

But yeah Pd-catalyzed Wacker oxidations can certainly use CuCl₂, as they indeed do. But it's important to carefully control the reaction for the best results. I would process it in batches back then, but using a flow reactor is probably better optimized, easier to handle, provides better control, and splits the reaction into micro-reactions thus limiting liabilitity, reducing risks, and facilitating multivariate testing of the reaction conditions if one wants to fine tune the optimization. I also understand that in legit industry this is easily scaled up.

Ah - a BL who can, I hope, help me to solve an open question.

I noted that people began to mention 'purple moonrock' MDMA and later just 'moonrock'. I'm guessing that the pathway was safrole-->chlorosafrole-->product. Now the thing is that early samples showed ring-halogenation with both -Cl and -I being present (but not -Br) i.e. a real mixture right up to trihalogenation.I summized that possibly certain aryl halide were responsible for the purple hue and the scale suggested a continuous process.

https://doi.org/10.1021/acsomega.1c05520

I noted this in passing. As I see it, the Chinese have correctly worked out that an exact purity measure isn't important as long as the product is 'potent'. So I suggest someone invested in a continuous flow process and that they hadn't optimized their route and quality improved as those involved became more experienced.

I don't consume MDMA nor do I find it's chemistry particularly interesting but if one has tens of thousands of gallons of Ocatea oil, batch synthesis isn't a good plan..

I noted the produce sometimes contains voids and curved esges hinting at the size and shape of the vessel. So could a spupercitical fluid have been used? One that would avoid the need for reduced pressure and/or heating to produce what does appear to be truly vast crystals? It's impressive and all, but I really wouldn't know where to begin with such technologies.

I like glass. People are often surprised at just how big pyrex can go. On Ebay recently someone was selling six or even eight 32L RB flasks with stillheads and condensors (6m long) to go with them. An essential oil producer had used them decades before and apparently one day someone just asked what was in all of those huge boxes in the corner,,, I 100% bet you £1 that the DEA were watching THAT sale with great interest.

 

[red22]

Strychnine and Parnate.

 

[Parabolan]

Captagon, and lots of it.

 

[letsparty]

In my decade of heavy poly use in Tucson, only once was able to find China white after trying a year to find it but liquid xanex when I got a bottle was the shit that almost killed me ( with Fetty )
( A nurse told me it may have been liquid lorazepam) Either way, I was told to take a drop ..not a full dropper or two as I did . Three days I lost all memory and did some wild shit that people still remind me of today.... Still haven't found my car keys or title.

 

[Damo_40]

I'm in Australia and I once ordered 20× extra salvia from the UK. Surprisingly it arrived in the mailbox. It was only 1 gram. I read that if you never done it before that you should start with 5× extract but me thinking I was a seasoned drug user stupidly went straight for 20×. It was the most intense, scariest drug experiences I had every had. I did it like 3 times with massive effect. My mate did it twice and there was still some left out of the gram that I threw away. It was like I was out of the world somewhere in the universe, like I was dead and my spirit was out there all alone away from my life, family and world I knew. The first time I tried it I forgot I had had anything which made it worse because I didn't know what was going on or that it would be over in 10-15 mins. The first time I smoked it the hallway in my house shrink to such I tiny size I was sure I couldn't walk down it haha. Every time I came back to reality I was covered in sweet. They say if you use it looking for a high it's the wrong reason. They also say with salvia there is often a female presence, which I didn't experience and either she likes you or she doesn't. Well I don't think she likes me haha. So I threw what was left over out on the grass back in nature where it belongs. I learnt to respect lady salvia and I just stayed away from her since. Peace out yall

 

[KetWise]

Hmmm...

Im not sure if it's actually rare, I've had dextropropoxyphene pills, adrenaline vials, nalbuphine vials, morphine vials, 'real' brown sugar in the producing country, ketamine vials, cyproheptadine, midazolam vials, Phenobarbital ...

MDE and 2ce

dissociatives ? 3-meo-Pce, O-pce, 3-ho-pce, MXPr, MXE snorted once

Stimulants ? I guess 3-FPM, NEH, 3-MMC, MDPV, 4-MMC, A-PVP smoked once

Depends where you are too.

Edit: morphine vial mxe apvp mdpv 4mmc added

 

[4DQSAR]

Hmmm...

Im not sure if it's actually rare, I've had dextropropoxyphene pills, adrenaline vials, nalbuphine vials, 'real' brown sugar in the producing country, ketamine vials, cyproheptadine, midazolam vials, Phenobarbital ...

MDE and 2ce

dissociatives ? 3-meo-Pce, O-pce, 3-ho-pce, MXPr, MXE

Stimulants ? I guess 3-FPM, NEH, 3-MMC, MDPV, 4-MMC

Depends where you are too.

Be aware that dextropropoxythene amplifies effects of compounds that increase levels of extracellular monoamines.

In the UK we saw a number of deaths among clubbers who it seems had discovered that after MDMA, dextropropoxythene makes the high last longer... a LOT longer.... I mean 12-16 hours from one pill longer.

Of course we only know this because inquests found both MDMA and dextropropoxythene in the bodies of the victims. But key - not level that would have been fatal if taken in isolation.

 

[JackARoe]

Xenon. Actually just kidding. Xenon was so hyped for a while but I suspect it is a glorified nitrous. I could be totally wrong not having tried it.

Me? Coleus? I had a friend that owned a greenhouse that had plants for sale. Whenever he cut back the coleus he would call me. I would take many leaves and chew them. One time I actually felt something like a light mushroom trip. But of course how strong is the placebo effect. Also I had the wrong set and setting. The one day I chewed 100 leaves I went out dirt biking on a hot summer day. Yeah hard to tell. A dark quiet room would have been better but I was 17 years old. Saw the notion in a book called Recreational Drugs that came out in the 70's.

I also tried hydrangea leaves. It was in that book. lol

The book had mentioned Donna Anna cactus too. Makes me wonder it anything is there. I do not know the technical name for this cactus. Never tried.

 

[4DQSAR]

Xenon was so hyped for a while but I suspect it is a glorified nitrous.

I totally agree with that assessment. What concerns me is that unlike nitrous oxide, xenon is used as a shield-gas (used in welding and so on) thus industral xenon (which is an order of magnitude cheaper than medical xenon) is the more likely to end up being sold by shady vendors.

I'm not saying that industrial xenon is automatically toxic, only that if industrial xenon is 95% pure, I would be asking what the other 5% is.

 

[KetWise]

Be aware that dextropropoxythene amplifies effects of compounds that increase levels of extracellular monoamines.

In the UK we saw a number of deaths among clubbers who it seems had discovered that after MDMA, dextropropoxythene makes the high last longer... a LOT longer.... I mean 12-16 hours from one pill longer.

Of course we only know this because inquests found both MDMA and dextropropoxythene in the bodies of the victims. But key - not level that would have been fatal if taken in isolation.

I've read your post about it earlier, quite curious side effects.

I've only had some years ago in europe before ban old stock then in central asia it was more 'popular'. I used to like it, never mixed it with MDMA, I had no idea it prolonged the high, thank god.

Dangerous molecule even on its own I think

 

[4DQSAR]

I've read your post about it earlier, quite curious side effects.

I've only had some years ago in europe before ban old stock then in central asia it was more 'popular'. I used to like it, never mixed it with MDMA, I had no idea it prolonged the high, thank god.

Dangerous molecule even on its own I think

Without a doubt dextropropoxythene is dangerous. I spend some time trying to find what medicines doctors had used to end their own lives (sadly it's far too common) and I'm sure you won't be surprised to learn that dextropropoxythene was a very popular option.

I wasn't seeking anything but pain relief but I look back and think 'thank goodness I only took three'. At the time I didn't know that the rule with paracetamol is 'not more than 4 grams in any 24 hour period' i.e. it doesn't matter if you take that 4 grams all at once or in divided doses. It's the body running out of the amino-acid needed to metabolize paracetamol safely that runs out once you break that 4 gram barrier.

I think I already knew how toxic dextropropoxythene was before I learnt the '4 in 24' rule but on that day, ignorance may have saved my life...

 

[unodelacosa]

Ah - a BL who can, I hope, help me to solve an open question.

I noted that people began to mention 'purple moonrock' MDMA and later just 'moonrock'. I'm guessing that the pathway was safrole-->chlorosafrole-->product. Now the thing is that early samples showed ring-halogenation with both -Cl and -I being present (but not -Br) i.e. a real mixture right up to trihalogenation.I summized that possibly certain aryl halide were responsible for the purple hue and the scale suggested a continuous process.

https://doi.org/10.1021/acsomega.1c05520

I noted this in passing. As I see it, the Chinese have correctly worked out that an exact purity measure isn't important as long as the product is 'potent'. So I suggest someone invested in a continuous flow process and that they hadn't optimized their route and quality improved as those involved became more experienced.

I don't consume MDMA nor do I find it's chemistry particularly interesting but if one has tens of thousands of gallons of Ocatea oil, batch synthesis isn't a good plan..

I noted the produce sometimes contains voids and curved esges hinting at the size and shape of the vessel. So could a spupercitical fluid have been used? One that would avoid the need for reduced pressure and/or heating to produce what does appear to be truly vast crystals? It's impressive and all, but I really wouldn't know where to begin with such technologies.

I like glass. People are often surprised at just how big pyrex can go. On Ebay recently someone was selling six or even eight 32L RB flasks with stillheads and condensors (6m long) to go with them. An essential oil producer had used them decades before and apparently one day someone just asked what was in all of those huge boxes in the corner,,, I 100% bet you £1 that the DEA were watching THAT sale with great interest.

Fascinating — hadn't seen that ACS Omega paper before, thanks for linking it.

Yeah, I've also seen "purple moonrock" MDMA go around and heard the chatter surrounding it, usually with the implication that the color/tint correlates to potency or purity (which we both know is a bit of a red herring). Your halogenation theory is plausible — iodine and chlorine showing up in early samples might reflect sloppy synthesis, particularly if someone was experimenting with halogenated intermediates or solvents that weren’t properly removed before crystallization. The lack of bromine is interesting though — maybe cost or availability played a role there.

As for the large crystal formations and those voids you mention, I agree it suggests non-trivial recrystallization conditions. Supercritical fluids could be a factor, especially if the goal was ultra-pure, slow-formed crystals without thermal degradation — but honestly, that seems like overkill (and too finicky) for clandestine operations. More likely: they’ve just dialed in a solvent system that works well under ambient conditions or slight vacuum, maybe something like IPA/acetone or IPA/ether depending on local chem norms.

Continuous flow synthesis from eugenol or safrole does make more and more sense though, especially on industrial scale. If they’re really working from tons of Ocotea, batch-style Wacker or AlCl₃-based systems wouldn't be efficient. I could see someone adapting an aqueous-organic biphasic system, maybe even pulling inspiration from pharma flow chemistry setups, just stripped down.

And yeah, huge glassware absolutely still shows up on the secondhand market. Pyrex gets retired from legit uses and scooped up quickly — the DEA’s probably got more eBay alerts set than most collectors do

 

[DeathIndustrial88]

Shit, not many for me.

Through out 2011-2013 I smoked a shit ton of different JWH-(or was it JHW, I can't rememebr) synthetic cannabinoids, but I never actually knew the names of each one. It was always packaged under various bud-themed tropes like "Northern Lights" and "Purple Blah blah". I wish I knew all the different chemicals I probably put into my body that year and a half. Every different type of "bud" was a unique high & different vendors had different types. Some of it scared the hell out of me though because I'd get some & it would be 100x more intense than the last batch or a completely different high altogether.


Only known "rare" drug I've done is Propoxyphene (Darvocet). It's "rare" now because it's banned. But I enjoyed it. Only got to use it for like 2 days. And it was actually expired pills, but they still worked. Worked enough to give me a nod & a very dreamy-esque type of buzz. But I've never had it since.

I've tried 2-CB, but I don't think that's necessarily "rare'.

Very jealous of everyone who's gotten to try all these obscure & rare opioids though.

 

[DeathIndustrial88]

dextropropoxythene

You mean dextropropoxyphene, right?
I'm curious how you could do so much learning & reading about propoxyphene, but then spell it the way you did several times. lol
And I don't mean that in a disrespectful tone either, I'm just curious. At first I almost thought dextropropoxythene was a totally different drug I had never heard of & I was like "wow, that's awfully close to dextropropoxyphene" lol. Until I looked it up & couldn't find any info on a -thene drug.

I just mentioned propoxyphene as my 'rare' drug, just before I saw your reply. lol

I enjoyed propoxyphene, but I had no idea at the time it was cardio-toxic either. My friend across the hall from me had been rummaging in her mom's basement one day & found an old pill bottle of either brand name or generic (can't remember) Darvocets. And she brought em to me so I could look up what they were. Found out it was propoxyphene, but I can't remember if I knew they were banned at the time or not. They were expired too, this was like in 2016, so they had been expired ever since the USA banned them however long ago. But they still worked just fine! lol Gave me a really nice dreamy nod. I had also just come down from a DXM trip that morning too, so that just made them even stronger when I used them that evening.

I liked it though. Never got to try it again since. These didn't have any acetaminophen in them or anything either, so I remember snorting a couple & eating a couple. I remember it having some similar qualities to methadone too in a way.

 

[SuperPsych]

Rarest drug that I've taken is probably HOT-7. As far as I know, it was released in two small batches over 10 years ago and hasn't made a reappearance commercially

 

[emkee_reinvented]

Qat/ Khat/ Catha Edulis, used it a lot. But unlike San Pedro, DMT holding plants.
Its illegal, so hard to get. Maybe via DW shit i imagine, though Qat needs to be fresh.
In NL its Illegal.

Hard to grow yourself, or impossible. Most drug s i like or hate i can still get or grow.
Ethroxylum Coca or Ephedra Sinica seem eassier. And more legal.

Otherwise i d say 2C-T2.

 

[4DQSAR]

You mean dextropropoxyphene, right?
I'm curious how you could do so much learning & reading about propoxyphene, but then spell it the way you did several times. lol
And I don't mean that in a disrespectful tone either, I'm just curious. At first I almost thought dextropropoxythene was a totally different drug I had never heard of & I was like "wow, that's awfully close to dextropropoxyphene" lol. Until I looked it up & couldn't find any info on a -thene drug.

I just mentioned propoxyphene as my 'rare' drug, just before I saw your reply. lol

I enjoyed propoxyphene, but I had no idea at the time it was cardio-toxic either. My friend across the hall from me had been rummaging in her mom's basement one day & found an old pill bottle of either brand name or generic (can't remember) Darvocets. And she brought em to me so I could look up what they were. Found out it was propoxyphene, but I can't remember if I knew they were banned at the time or not. They were expired too, this was like in 2016, so they had been expired ever since the USA banned them however long ago. But they still worked just fine! lol Gave me a really nice dreamy nod. I had also just come down from a DXM trip that morning too, so that just made them even stronger when I used them that evening.

I liked it though. Never got to try it again since. These didn't have any acetaminophen in them or anything either, so I remember snorting a couple & eating a couple. I remember it having some similar qualities to methadone too in a way.

No, no - entirely my mistake. I am dyslexic so as you can imagine, I didn't really enjoy higher education. I endured it but I had to walk around with a copy of The Merck Index for many years.

As I said, I had no intentention of getting high off the dextropropoxyphene and it's just amazingly lucky that I didn't know the "4 in 24" rule or I may have been tempted. I just walked into my home a bit frazzled and wanting to go to bed and WHAM, it was like I had consumed another pill.

If three has that effect, I don't want to even think about what ten would do. But evidently others discovered the same thing as, sadly, in the UK we saw quite a few deaths in which MDMA and dextropropoxyphene were the only toxins found by the coroner.

BTW ages ago I found a paper which described a rigid homologue of dextropropoxyphene