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(R)(+)-Diphenyl-2-pyrrolidinyl-methanol

MDPVagrant, PNS stimulants greatly increase the amount of calories you burn during and after exercise, so they tend to be great for someone trying to lose weight and tone muscle (cutting phase). But, I didn't take the stimulant with working out in mind - it was just still in my system when it was time to go to the gym.
 
Hey MDPVagrant, I imagine that all stimulants get more and more 'evil' for certain users over time and level of abuse. It certainly was the case for me (I only ever messed with methamphetamine and amphetamine though). Progressively they get worse and worse...and you want to stop...yet its very hard to stop... :\

I asked myself one day: what am I getting out of this? I'm getting an exhausted body and some moments of euphoria and ruined relationships. Its not worth it yet it was incredibly difficult to stop. :\

The sooner you stop the better.
 
^ I agree that strong stimulants , particularly via intravenous administration, are 'evil' and yes they destroy your life and health, sometimes permanently! Worst type of addiction you can get IMO!
 
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I way overdid it the other day (a dose of 100mg to 150mg) and didn't notice ANY peripheral side effects. I did have a gurgling stomach all night and sweated a lot, but otherwise I felt great physically.

Mentally however, I had severe anxiety and was sloppy and stupid like I was drunk. At one point I had a psychotic break and I'm still recovering from the paranoia.

As far as it being addictive, I can't imagine that for myself because I felt no euphoria and no desire to re-dose (I just wanted it to wear off so I could fall asleep and escape the paranoia.)
 
what surprises me with this compound is that for me it seems really tricky to find the right dose. this may be related to drastically different pharmacokinetics with different routes of administration.

for oral admin i found the dosage range very thin:
up to 50mg - nothing
60 to 70mg - light but long lasting stimulation
~80mg - relative strong stimulation, teeth grinding and meth-like "which way is poland" thoughts. ;) no need to go higher.

insufflating and vaporizing were much more efficient but are not advisable for the sake of mucous membranes. 10mg produced shorter but comparable effects to 60mg oral.
any ideas why much higher oral doses are needed with this one? first-pass effect? poor absorbtion?
and why seems the dosage range so thin? is this a peculiarity of diphenyl prolinol or is it the same with pipradol or its deoxy analogue?
 
Summary of findings so far...

(1) Approximately 1/3rd as potent as MDPV (on an overall basis). In other words: given free access by the lab animal, a given amount will be used up about three times faster. Sorry, this data is probably not very useful. In terms of single doses, it is significantly less potent than MDPV.

(2) The effects are self-limiting, and a point of strongly diminishing returns is reached at some point. However, much like methylone, the desire to use more does not diminish at any time. My experience seems to differ from the norm with this one, and I'm not sure why.

(3) There's a significant body load, and physical exhaustion and/or toxicity can become a factor with extended use and higher dosing.

(4) Administered rectally in solution, it is as compulsive as any dopamine reuptake inhibitor, perhaps more-so than usual. Given (3) above, this combination is not very positive.

(5) As noted in post #47 above (but I'd like to make a stronger statement): Nasal insufflation is a bad idea, unless the test subject is a confirmed masochist. There is a similar effect in the nose as in the throat when ice cream is swallowed way too quickly, and rinsing the nose does not immediately diminish the pain.

(6) It does indeed have a somewhat narrow 'therapeutic index' as noted in #47. Why? Most likely just its particular pharmacokinetics.

Although it is recreational (low-moderate at best) when dosed rectally, IMO this is really the "utilitarian" dopaminergic that students and truck drivers would appreciate. Perhaps it would also be useful as a self-treatment for cocaine addiction, I don't know. With a narrow therapeutic index, dosage will have to be carefully titrated.

I'll be undertaking another experiment with this substance soon (interested in seeing if it's compulsive at all when dosed orally, as well as more closely determining when compulsion 'kicks in' during a period of prolonged use). However, I'm not very interested in this substance any more, so any further tests will be widely scattered.
 
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Well there's one moment that was possibly a hallucination, kind of a flashback to some old bad trips. I don't like benzos or sedatives, nor would I take any of them at work.
 
a bit of a binge

I tried this stuff for the first time on wednesday. Because I was dosing at work and didn't have any scales I ended up consuming ~350mg (orally, over about 7 hours) and another ~200mg the next day, which I guess was a tad foolish. I found it to be quite euphoric and really useful for concentrating on work, I also only got 3hrs sleep over 2 nights. A big downside is that I have noticed the energy, jaw clenching etc lasting up to 19hrs after the last dose, I don't remember MDPV lasting that long!?

If MDPV was 10/10 then this chem would be ~ 5/10 IMO.
 
It comes at a high price, but...

fastandbulbous said:
No matter how much you take, you're not going to get a strong stimulant like sensation; the Ki for binding & reuptake inhibition are too far apart.
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I have found this to be false; it is possible to eventually get a strong stimulant-like sensation, after dosing somewhere between 'high' and 'suicidally high' over the course of many hours.

At that point you've likely got full reuptake inhibition (through sheer amounts of the drug), in addition to that incredibly tight kibinding. Also, high blood levels would likely extend its effects significantly longer than usual.

It seems to me one is just begging for dopamine psychosis under the circumstances, not to mention other unknown but potentially serious problems. However, it is in fact possible to get that "recreational stim" effect, for a price... I would be the last person here to ever recommend it, but the option does exist.
 
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know many who tried it

while it has some nice properties it is simply not a rec oriented compound or something that a typical stim-head is going to want to bother with with many other superior options available
 
At that point you've likely got full reuptake inhibition (through sheer amounts of the drug), in addition to that incredibly tight kibinding.
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That isn't the important thing, the ratio of Ki binding to Ki reuptake inhibition is what determines the 'strength' of the stimulation. Although all the receptor sites might be occupied, not all of them are inhibited. It's the percentage of ones with the drug bound that are prevented from reuptake that determines just how much of the neurotransmitter stays in the synapse
 
does anyone here know, if it´s save to mix something like bk-mdma, that releases a lot of dopamine with Diphenylprolinol. I don´t know anything about brain chemistry, but from what I know, i thought it might be dangerous to combine something that releases dopamine with a reuptake inhibitor.
But i´d like to hear an experts point of view. I know people have mixed mdpv with methylone, but is it considered safe?
 
Given my own experiences, I wouldn't mix anything with diphenyl prolinol. Unless perhaps you were keeping the dose very low.

P.S. you'll find few or no "expert" opinions around here... I'm not aware of anyone who has supplied provable credentials. If you need professional or expert assistance, you are in the wrong place altogether IMO.
 
i actually meant an "experts" point of view. Some people seem to know a lot more than me about brain chemistry. But probably you right, shouldn´t mix it with anything
 
MDPVagrant said:
Given my own experiences, I wouldn't mix anything with diphenyl prolinol. Unless perhaps you were keeping the dose very low.

P.S. you'll find few or no "expert" opinions around here... I'm not aware of anyone who has supplied provable credentials. If you need professional or expert assistance, you are in the wrong place altogether IMO.
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Do you really think any of the many people here who possess "credentials" are going to give up their identities by posting them?

I don't know of many "real world" experts who would be very interested in answering unsolicited questions regarding the recreational use of obscure substances.

Of course the only safe thing to do is stick with fda approved drugs=D
 
I have tried this one a while ago.
hated every minute of it and wanted it to just stop. It was very much like taking a hell of a lot of ritalin (. I took 500mg in one pop though
 
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