• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

(R)(+)-Diphenyl-2-pyrrolidinyl-methanol

AuraithX

AuraithX

Bluelighter
Joined
May 22, 2006
Messages
4,503
I've just ran into some of this stuff and some info would be nice, thanks :)

I've found a Trip Report but can't find much else!

Edit:
Synthesis of diphenyl-2-pyrrolidinyl-methanol and diphenyl-2-pyrrolidinyl-methane

Smyth said:
Compound Kibinding Kiuptake Kibinding/Kiuptakeratio
Cocaine 0.12µM 0.20µM 1.67
(R)(+)-Diphenyl-2-pyrrolidinyl-methanol 0.04µM 0.17µM 4.25

This particular chemical is thought to be not very addictive because it is very good at occupying the receptor site but dos not do a very good job at inhibiting dopamine reuptake. Atleast this is the theory that persons working in drugs design have been using. I have head first-hand from somebody who has tried some of this chemical that it gave them no pleasure and that they felt no need to repeat the experience. The current DAT inhibitor featured in the thread title however does look to have alot more promise as a dopamine inhibitor.
Click to expand...
 
Last edited:
I'm confused about which isomer is the more active one here, every report / RC vendor I've come across talks about the R isomer, but the rhodium article says the S isomer is the one you want...anyone shed some light on this for me???
 
Last edited:
The Rhodium article/collected data confusingly talks about 2 rather similar (to the untrained eye) but different compounds. Diphenyl-2-pyrrolidinyl-methanol which can be reduced to diphenyl-2-pyrrolidinyl-methane. As the table indicates the R-isomer of the methanol is the most potent (lowest Ki binding and uptake), while the S-isomer of the reduced methane presumably seems to be the most potent. The product avaible by RC vendors is the methanol (probably due to the fact that it is supposed to be more potent, which however doesn't seem to be the case really).
 
You should be able to hydrogenate it to remove the hydroxyl pretty easily.
Pity there's no Ki data on the desoxy compound.
 
Yeah, and it would be great if some french speaking Bluelighter could translate the entire original french patent. Might be some good stuff there.
 
AuraithX said:
Anyone be able to tell me the short-hand for this also? :)
Click to expand...

Iin industry and chemical synthesis where it is readily avaiable it is called diphenyl prolinol.
looks to me like some uncreative RC vendor has discovered this is industrially available and is repackaging with a huge markup, one of the pre web trip companies, I forget which, was doing a similar thing.
 
Certainly uncreative with all these reports of human activity... 8(

I've trialled to 40mg, to little effect except central (not caffeine like) stimulation. Will report back with more details after a 75mg (as propossed elsewhere) is ayyempted!
 
No matter how much you take, you're not going to get a strong stimulant like sensation; the Ki for binding & reuptake inhibition are too far apart. Still it has a definite use as it produces very clear headed wakefulness, not the scatterheadedness that comes with amphetamines
 
^Ah, an expert! Would acetylation speed the drug through the BBB for a faster action?
 
Well, oh font of knowledge, will acetylation be of any use? Also, check your PMs!
 
The french stuff just has 1 graph. 1! It just graphs reserpine (a depressent) against the desoxy compound at different concentrations over time on rats. No proper data except that they suggest between 100 & 750 mg daily for adults, starting with 100mg. Dosed divided into 25-100mg units. They give the reduction of the methanol version EXCACTLY like the one in the document. Whoever did the paper could read French and decided there was nothing of value, I assume...
 
Last edited:
And is much more addictive... a nice report would be appreciated!
 
Well, from the trip report & the French data, I would drop 50mg right away... but then I'm just dumb!
 
Hope your getting the salt and not the freebase! If it's freebase, smoke it!
 
One thing SIM enjoy about diphenyl prolinol is that it gives a kind of dual-sided clear-headedness at the same time as it is almost psychedelic. SWIM clearly feels intoxicated when walking, balance is just slightly off, not bumping into stuff, but movement feels softer. Walking fast is enjoyable.

SWIM have done two further bioassays at the same dosage (around 25 mg) and not really felt a need to increase dosage, even though SWIM surely will do that sometime soon.

SWIM would be interested in combining with small dose of 2-aminoindan, what do people think about that idea?
 
Please don't use the acronym SWIM; it's annoying and does nothing to conceal your identity.
 
You must log in or register to reply here.
Top