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  • BDD Moderators: Keif’ Richards | negrogesic

Bupe Quitting Buprenorphine. When is is completely out of your body?

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Elimination of buprenorphine is bi- or tri- exponential, with long terminal elimination phase of 20-25 hours, due in part to reabsorption of buprenorphine after intestinal hydrolysis of the conjugated derivative, and in part to the highly lipophilic nature of the molecule.

Buprenorphine is essentially eliminated in the faeces by biliary excretion of the glucuroconjugated metabolites (70%), the rest being eliminated in the urine.

Hepatic impairment : The effect of hepatic impairment on the pharmacokinetics of buprenorphine and naloxone were evaluated in a post-marketing study. The following table summarises the results from a clinical trial in which the exposure of buprenorphine was determined after administering a Suboxone 2.0/0.5mg (buprenorphine/naloxone) sublingual tablet in healthy subjects, and in subjects with varied degrees of hepatic impairment.
 
ibtisam midlet said:
opiates usage in weekends is addictive you should think of once a month
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For sub? You really think just doing it on the weekends would get me addicted again? I always thought you had to do it like 5 days or something like that in a row to get physically addicted.
 
darvocet21 said:
@Ganjcat is promethazine available without a prescription in the UK? What was this other one you were talking about ...is it a low dose codeine?
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Yes and yes the promethazine 25 mgs and cocodomal 500mg paracetamol and a whopping 8mg codeine.. I must have crushed, dissolved filtered and swallowed thousands of them.. screw you anti abuse mechanisms
 
Crystal Zelda said:
For sub? You really think just doing it on the weekends would get me addicted again? I always thought you had to do it like 5 days or something like that in a row to get physically addicted.
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It would be because at the dosage your taking it, after a week you should still have active levels of the drug in you, back when I took as much as you were, the detoxes lasted a month, but the worst of it was over in 1-2 weeks, and I have an extremely fast metabolism
If you only took like 0.5 mg a week (sublingual, if your shooting it, 150 mcg) you’d probably be fine
Though below 2 mgs, bupe is much stronger per mg due to the bell curve effect
You still have enough in your system right now to cause an effect, I’d estimate you still have something like 50-100 mcg in you
 
polarthedog said:
It would be because at the dosage your taking it, after a week you should still have active levels of the drug in you, back when I took as much as you were, the detoxes lasted a month, but the worst of it was over in 1-2 weeks, and I have an extremely fast metabolism
If you only took like 0.5 mg a week (sublingual, if your shooting it, 150 mcg) you’d probably be fine
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The last two weeks I was eating suboxone pills and it was like 2 mgs to 4mgs a day.
 
Crystal Zelda said:
The last two weeks I was eating suboxone pills and it was like 2 mgs to 4mgs a day.
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To estimate how much is in your system right now, assume the half life for you is 24 hours(if your a fast metabolizer), write down the dosages for every day for about a week of your usage, each dosage will have half lives independent of the prior doses, so let’s say you took 2 mgs a day, the 2nd day ofmusage, you would now have 3 mg in your system, the 3rd day you would have 3.5 mg, the 4 th day you would have 3.75 mg, the 4th you would have 3.875 mg, the 5th you would have about 3.95 mg, ( I’m doing this in my head so my maths probs off a little, the 6th you’d have 4 mg ish, And the 7th you would have about 4.025 mg, the. Let’s say you stop on day 7, 24 hours after stopping, you now have 2.0125 mg, then for every day after it splits, not considering the other metabolites which metabolize slower. Due too the bell curve effect, which basically says that when your dose exceeds about 2 mgs, buprenorphine begins to have less effect for each mg you increase, so increasing from 1-2 mg would be the difference between 2 and 4 mgs, and that would be the equivalent change in effects between 4 and 8, so the lower you go, the stronger the bup is per mcg, so because of that, the stimulation to your opiate receptors would not significantly drop for atleast 48 hours after your last dose, and for the effects to completely dissipate, I oil do estimate it would take atleast a week, though by that point if you are physically addicted, you won’t notice a high, it will just be keeping you partly out of the worst of the withdrawals. All that was rough estimates just to demonstrate what half life means and the bell curve effect, how fast it metabolizes Varys from person to person and could be influenced by factors such as how much exercise you get or how much you eat, how long you have been using, Ect
 
I’d say within in the next couple days your levels should drop enough to where the stimulation to your receptors becomes insignificant
 
O
ibtisam midlet said:
its because of psychology addiction (craving) not dependence, craving will lead to more intake of the drug to 3 to 4 and ultimately lead to taking subs daily which will cause dependence.
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Ok I see what your saying but I don’t know if you’ve seen it in my other posts but I’ve been withdrawing for 7 days with suboxone in the other room so I trust myself completely to not overdo it
 
Crystal Zelda said:
Lol what does that mean?
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I mean that you have enough bupe in you right now most likely to keep you slightly out of withdrawal. Your withdrawal has not entirely begun yet, bayou have a few days left until the drug completely leaves your system, then about 2 weeks after that, you should be finished with most of the withdrawals. So If you want your tolerance to reset, you need to not use any5ing for atleast another two weeks, also, you probably still have clonazepam in you that ismcausing an effect since the half life( a half life is the time it takes for your body to metabolize half of the drug) is very long with that to, basically what I’m sayin* is you got a while to go, and if you take 5 mgs one day a week, your basically using the drug every day, because your not giving your body enough time To completely metabolize it
 
Nautica24 said:
Elimination of buprenorphine is bi- or tri- exponential, with long terminal elimination phase of 20-25 hours, due in part to reabsorption of buprenorphine after intestinal hydrolysis of the conjugated derivative, and in part to the highly lipophilic nature of the molecule.

Buprenorphine is essentially eliminated in the faeces by biliary excretion of the glucuroconjugated metabolites (70%), the rest being eliminated in the urine.

Hepatic impairment : The effect of hepatic impairment on the pharmacokinetics of buprenorphine and naloxone were evaluated in a post-marketing study. The following table summarises the results from a clinical trial in which the exposure of buprenorphine was determined after administering a Suboxone 2.0/0.5mg (buprenorphine/naloxone) sublingual tablet in healthy subjects, and in subjects with varied degrees of hepatic impairment.
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This is my favorite kind of post. If you ever want to hang out and discuss pharmacokinetics, I'm down
 
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