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Quetiapine+psychedelics seizure risk

crOOk

Bluelighter
Joined
Dec 16, 2004
Messages
4,054
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Germany
I was recently prescribed quetiapine and while browsing erowid experience reports I realized there is a shitload (!) of reports about quetiapine + lsd and q+random psychedelic which end up with the psychonaut experiencing seizures and/or being hospitalized due to the seizures or a severely psychotic state. Since I recently wrote a mod about another unadvisable drug combination and received no reply, I thought I'd just drop it in here in case someone ever searches for information about the combo. Definitely sounds like a full-on no-go lol.
 
What are you taking that garbage stuff for? You didn't go telling the doctor that an elf from hyperspace blasted in to your room on a flame shooting out of your pipe, did you?
 
Quetiapine itself is a "full-on no-go". Just about the only justifiable scenario for taking it is if your psychotic cognitive impairment is getting so bad that you seriously fear you will soon end up in the nuthouse, curled up in a corner, muttering unintelligible gibberish to yourself while drooling all over your shirt.

If you are not in this situation, you would be well advised to stay off the Quetiapine. Unless you get kicks out of spending a lot of time in a physical stupor, having nightmare hallucinations, and enjoy the odd random muscle spasm from time to time.
 
^ i wonder if you have personal experiences with Quetiapine or other antipsychotics? there are lots of people who are glad they were prescribed that kind of medication. i was prescribed Olanzapine (Zyprexa) myself and took it for some weeks to get through a really bad state and it definately helped me. and btw, not every person gets all the bad side effects, the only SE i got from the zyprexa was that i gained a bit of weight and became lethargic, but that was way better than being close to freaking out all the time. i kicked it when i felt confident that i had the worst behind me though.
 
^ I do have personal experience with antipsychotics. I have not taken them myself, someone very close to me has, and through this person I had the opportunity to meet other people suffering from mental disorders that precipitated their use of AP medication.

I understand that antipsychotics have their place in the world, although it's mostly because, as a society, we are not set up to accomodate people suffering from psychosis and related disorders, and therefore, sometimes, the only option for people who are dealing with this ailment is to take a pill to coast them over the difficult periods.

Having said this, it is my impression that Quetiapine tends to be especially unpleasant and difficult to tolerate. I have not heard anything /but/ horror stories about it, and this is not true about all AP medication. FWIW, Olanzapine seems to enjoy a lot better reputation. Weight gain and lethargy are among the most common complaints about Olanzapine, and that's not that bad, considering.
 
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What are you taking that garbage stuff for? You didn't go telling the doctor that an elf from hyperspace blasted in to your room on a flame shooting out of your pipe, did you?
lol nah but i told friends and family im being eaten by mushrooms. Had a full-blown manic episode for half a year... Crazy long story really. Stopped studying medicine, started coding. First project got me sued by Blizzard, who terrorized me for the past half year through my lawyers who did a 180 on me. Shit was just getting way too much and I just couldn't stop working. The amount of sleep I got decreased continuously until I reached a ~10h sleep after 65-70h waking schedule. Kept havin hallucinations, fucked up a lot of things on the social side. There really was no other option than seeking treatment. I feel really fuckign healthy when I've taken my olanzapine, healthier than I've felt in years. I'm really grateful that drug exists, although I don't plan to take it forever...

Got huge responsibility for my daughter and I want to see her grow up as happy as possible without having to worry about her dad being sick and falling apart further with every day that passes by, before she even enters school. Really my goals are quite humble: Make a living in coding and reach age 55 minimum, ideally put some cash aside for my daughter though she should be good either way... Really I should be able to accomplish these things, but not when I'm hallucinating all day long, am going nuts over having some infectious disease, not eating, not sleeping and starting fights over the most ridiculous things.

Anyway, I was actually curled up unter the shower muttering gibberish at one point in time. A huge part of the problem is that people extend the change in expectation towards what you're saying to pretty much everything. I truely believe that there could be a lot of relief to many shizophrenics and manic or otherwise sub-acutely psychotic people, if someone actually took them seriously. I had a taste of that a few times and each time there was a huge improvement in me afterwards. It was extremely calming. Ofc this is understandable when someone is having huge trouble expressing whatever it is he means to say in a few simple and clearly understandable statements. On one hand there was intense pressure of speech for me all the time, on the other sentences became huge and cryptic lol. Sometimes I'd just chase after the words and try to keep up with their meaning, other times I was underlining random words with sounds and gestures, suddenly switching to a completely different context mid-sentence, just completely lost, but producing a lot of words nonetheless lol.

On the other hand you are right that there is no role for the crazies in our culture and this also adds huge weight to the problem. Nonetheless it is what it is and the shit helps. I have abused so many fucking substance or tried to self medicate, I just don't give a shit. I've long given up living drug-free to be honest. If it's an antipsychotic that can maintain me, so be it. I just want to get by in this shithole and I honestly am more than happy if that can be managed. Being manic meant losing ability to perform so many tasks that usually were completely automated, hygiene, cooking, emptying the mailbox, just getting in touch with anyone on the outside. Nonetheless Quetiapine and Olanzapine are top-notch antipsychotic and if they help, then fuck whatever damage they could eventually do.

I was surprised there is very little information on increased cognitive performance during hypomania. Usually it says all these abilities are impaired on some level. I am still blown away by what I actually accomplished during those 6 months, even if half the day was spent in cataleptic freeze lol. I could have never done that without the "megalomania" lol. I had some of the best moments of my life during moments of greatest delusion (again, possessed by benevolent ancestral spirits lol) and met an unusually high number of very interesting people. Ultimately, I got out of it just fine eventhough it seemed I lost everything for a while there. I can't say I want to miss anything I experienced during the past year, eventhough it could definitely be viewed as the shittiest year so far lol.
 
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