The questions I'm really curious about are how methamphetamine and cocaine relate. I've read many technical papers on both drugs but haven't cleared up some questions.
My understanding is that they affect the same dopamine center of the brain but in a slightly different way. But their subjective effect, while similar, is exceptionally different.
Meth for me is very entheogenic and positive. I experience many of the positive effects I get from other entheogen/psychedelics (meth is after all a phenethylamine). Only meth produces almost no direct hallucination effect as opposed to say mescaline. Meth especially and potently targets a dopamine center in the frontal cortex more than any other entheogen I'm aware of.
(In my experience): Cocaine is very flat in comparison. It completely lacks any entheogenic/psychedelic effect at all. It produces significantly more anxiety and increased heart rate. It lacks a certain enjoyable euphoric effect that meth has. It produces certain very powerful and as far as I know, unique and very unusual effects on the brain. Effects that I've seen in some people make them go totally insane, behave in outrageous ways with a total and massive personality shift, but only for the brief time they are directly under the influence (granted meth has a psychosis, but that is after days of sleep deprivation or many months/years of chronic excess abuse and is markedly different than the psychosis of cocaine. I'm basing that proposition on the cases of meth and cocaine psychosis I've directly and intimately witnessed).
And of course the molecular structure of cocaine is very different from phenethylamines.
It would be nice to read some technical papers on how meth is able to do the things coke doesn't and coke does the things meth doesn't.
Also if anyone has interesting stories or personal experience information about these differences, especially on meths entheogenic side that coke lacks.
Some of the big questions that I've been wondering about:
How is it that meth is so much safer than coke in terms of overdose and seriously dangerous adverse effects? My understanding is that it is rare or difficult to overdose to the point of death on meth, but for coke it is much easier and has happened quite a lot more.
The speedball is infamous for being extremely dangerous and so many people have died from it.
But I've heard very little about the goofball (meth and heroin).
Are there many reported cases of death from goofballs? Is the goofball as dangerous as the speedball?
(If it is true) By what pharmacological aspects is it that the goofball is so much safer than the speedball?
I've done goofballs many times, sometimes with very high doses (with tolerance, back in the day I was partying hard) and have always found them extremely enjoyable. So much that if I were to take a drug for pure party and recreation purpose I would not want to take either meth or heroin by itself. I might say that they really must be used in combination the effect is so good and as a purely pleasure producing drug experience the goofball is by far the very best.
The speedball is really terrible by comparison (in my experience).
