Question regarding extended release pills?

[yo0123yo]

I recently grabbed a couple of 20mg extended release OP20 oxycodone pills and a buddy of mine was saying that the way they work is that half of the dose is instant release and the other half is released over time, is this true? If not then how does the extended release formula work? Thanks

 

[nAON]

I assumed it was distributed fairly evenly over time. I know the peak is about 4-5 hours and it lasts a few hours longer than that. And it works just by gelling it up and only allowing a certain amount of the drug to dissolve/absorb per unit time.

 

[Tommyboy]

^ yea it appears to be distributed even over time.

Plasma Oxycodone Concentration over Time
Dose proportionality has been established for OxyContin 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, and 80 mg tablet strengths for both peak plasma concentrations (Cmax) and extent of absorption (AUC) (see Table 3). Given the short elimination t½ of oxycodone, steady-state plasma concentrations of oxycodone are achieved within 24-36 hours of initiation of dosing with OxyContin. In a study comparing 10 mg of OxyContin every 12 hours to 5 mg of immediate-release oxycodone every 6 hours, the two treatments were found to be equivalent for AUC and Cmax, and similar for Cmin (trough) concentrations. [source]

That's what I got from reading the quote above from the Purdue website I linked to at the end of the quote.

 

[A2Z&NBETWEEN]

th3y 5uck