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  • TDS Moderators: AlphaMethylPhenyl | paranoid android

Mental Health question on therpuetic use of dexedrine

A

AlphaMethylPhenyl

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So I asked a pharmacist this question and she basically thought I was asking if I should up my dosage. That's a last resort for me. I want to stay on this current dosage for the rest of my life. I take 25mg Dexedrine ER. I want to know how long of taking it continuously it will take until the effects don't diminish anymore - until I have a sustainable effect each time I take it. Couldn't find the answer online and the other thread is about methylphenidate without asking this question specifically. I also took it for six months before, with a six month break. When I took it for the first time I could tell that tolerance didn't entirely go away but that's ok; that's not really my question anyways.

I know that the effects on concentration are supposed to be continuous as well as that on blood pressure and it makes sense that there's a mild ad effect given reuptake inhibition and more so maoi inhibition.

I guess this is just for people who either don't abuse their meds or abuse them very rarely. Any studies would be much appreciated.
 
You're hoping for an impossibility. There is no length of time you can take it that tolerance "bottoms out" - that is, effects will diminish the more/longer you take it; what you're hoping for is unrealistic.

Mild ad effect? Amphetamines have the strongest a/d effect, they're also euphoric which is completely different to a/d (unless ad doesn't mean anti-depressant)


Look into tolerance prevention. Take your 25mg on weekdays and have the weekends off.
There's nothing you can do to escape diminished effects, it is inherent/inevitable, so you're best off trying to retard/minimise it. (I'm sure you're aware of the tol prevention thread)
 
Hmmm so you're saying it goes down indefinitely?

I would differentiate an anti-depressant effect from a euphoric one. An anti-depressant effect doesn't necessarily cease with constant usage, whereas a euphoric one always does.

I take chelated mg and am switching to zinc soon.
 
I would also differentiate a/d to euphoria, hence me bringing it up. I(t) would be foolish to think sustained non-rec doses are exempt from diminished dopamine release, which is essentially the "a/d" effect.
Amphetamines are very effective anti-depressants (in the true sense of the word) in short term, but they're also euphoric (and tolerance is an issue.)
Depression and euphoric drugs don't mix. For example, compare tranylcypromine to dextroamphetamphetamine. Which has a better side effect profile? Which releases DA and NE 10x as much? (Hint: same answer for both)

(real) Antioxidants are your friends, good luck. (your mind is paramount to/much more sensitive than your BP/body... unless you're otherwise unhealthy)
 
uhh I don't think you're qualified to answer this; there's a lot more than "dopamine release going on". do you have personal experience?
 
MAOI's do not suffer this issue at the same rate. Anti-depressants that release MATs only affect SERT. There's a reason Dopamine releasers aren't used for depression.
TAAR1 affects dopamine and norepinephrine much more than serotonin.

I'm sure the mild MAOI effects and competitive reuptake inhibition are much more responsible for the "anti-depressant" effect you're experiencing.
Have you even read about dexamp? the MAOI effect at 25mg is not very strong, not even taking into account tolerance.

Seeing as you're asking for studies, I sure hope you know how to "proof read" a study.

Good luck again. I don't have experience with long term daily amp use, no.
 
MATs?

Well, yes, read quite a bit on it. I know the maoi effect wouldn't be that strong at such a dose, hence it being a "weak" maoi. Yeah I can generally tell if a study is sound but I honestly, after searching for hours and hours, haven't found the answer to this question. I'm almost bound to say that no-one knows how long of continuous use at a continuous dose it takes for the effects of amphetamine to stabilize. The best I could get was the pharmacist stating that "people remain on stable doses for years", though how many she didn't say. I guess it wouldn't necessarily be a bad thing to raise the dosage by 10mg or so every 5-10 years. As for now I'm fairly satisfied.

Thanks for the response anyways.
 
I've been on 30 mg's/day for for about a year now and the effects are still the same. After a week of going 15 mg's a day it wasn't doing much but 30 mg's feels just right. If tolerance would rice indefinitely this wouldn't be possible. I do find that the "recreative" effects diminish though. Euphoria fades, appetite returns, sleep returns to normal, but in actuality the clearheadedness and ability to focus which is the reason I'm taking it is strong as ever. Can't help you with a study but it's my personal experience.
 
There's a study showing reverse tolerance at 40mg per day. Personal experience with Dexedrine has shown me that tolerance isn't a huge issue but due to the nature of the drug itself, the higher the dose the more peaks and valleys occur. I found defeating the er and taking 40mg twice a day to be effective before I started abusing it to death. The low mood that hit after 2 or 3 hours and then at 7 or 8 hours made it impossible for me not to abuse. IMO if u aren't abusing it then 40mg a day is roughly the sweet spot for most people. I'd find that study but I'm not at my computer but try googling Dexedrine and reverse tolerance.
 
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