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Question on the effects of Dopamine agonist.

Psychedelic Jay

Psychedelic Jay

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Would combining a Dopamine agonist such as Ropinirole to boost euphoria of your normal drug regimen?

This would be only used when the D.O.C. (Oxycodone, or equivalent dose of other opiate painkillers.) is used, weekends.
 
Sorry to hijack the thread, but what about aripirazole (Abilify)? Is it a dopamine agonist too?

Woudl it boost opiates like some other -azole medicines (sorry I don't have a better term).
 
If I was you, which Im not, I would seriously not add that drug into the mix for anything.

Im not trying to sound like a mother or anything, but seriously, leave that shit alone.

If you are looking for more high or euphoria, change to a better and stonger opioid.

(I realize the irony in my statements. However, I think its safer to find a stronger/better drug than to play crazy therapist on yourself. Maybe find a hamster, then try the combo on it ;) )
 
I wouldn't worry so much about combining aripiprazole with opioids as a general rule, but you'd want to watch out for increased respiratory depression until you were familiar by the effect. I once made the mistake of combining quetiapine with methadone. terrible experience. heavily depressed respiration and a dissociative-ish feeling (similar to a low dose of dextro-methadone, I suppose, which I have only tried once) with completely numb skin and a generally disgusting feeling.

Not the same thing, but be extra careful with this sort of combination, I don't think many people combine opioids and neuroleptics for a reason that while the latter may increase the sedative aspects of the opioid, it will eliminate or greatly distort and diminish the euphoric properties you're seeking. It's also safer not to.

Regardless, Abilify isn't what the author of the initial post had in mind. He wants to know about dopamine receptor agonists, not antagonists (or partial agonists as I believe aripiprazole is). They're as different as morphine and naloxone.

Dopamine agonists like ropinirole are unlikely to increase the euphoric aspects you're seeking, but they'll definitely increase the habit-forming-ness of the drug. They're well known for creating unusual and strong addictions (perhaps better termed compulsions in this context) making moderately enjoyable things like gambling and shopping habit forming more like heroin (not exactly of course) than caffeine, as they normally are.

Still, some very selective dopamine agonists lack the nauseating effects they're known for, and many are known to alleviate withdrawal symptoms and reduce craving. Increase euphoria? I don't know.

I have been looking into some of the agonists that aren't commercially available, but I've not made any plans for which one I will give a shot.
 
Hammilton said:
I wouldn't worry so much about combining aripiprazole with opioids as a general rule, but you'd want to watch out for increased respiratory depression until you were familiar by the effect. I once made the mistake of combining quetiapine with methadone. terrible experience. heavily depressed respiration and a dissociative-ish feeling (similar to a low dose of dextro-methadone, I suppose, which I have only tried once) with completely numb skin and a generally disgusting feeling.

Not the same thing, but be extra careful with this sort of combination, I don't think many people combine opioids and neuroleptics for a reason that while the latter may increase the sedative aspects of the opioid, it will eliminate or greatly distort and diminish the euphoric properties you're seeking. It's also safer not to.

Regardless, Abilify isn't what the author of the initial post had in mind. He wants to know about dopamine receptor agonists, not antagonists (or partial agonists as I believe aripiprazole is). They're as different as morphine and naloxone.

Dopamine agonists like ropinirole are unlikely to increase the euphoric aspects you're seeking, but they'll definitely increase the habit-forming-ness of the drug. They're well known for creating unusual and strong addictions (perhaps better termed compulsions in this context) making moderately enjoyable things like gambling and shopping habit forming more like heroin (not exactly of course) than caffeine, as they normally are.

Still, some very selective dopamine agonists lack the nauseating effects they're known for, and many are known to alleviate withdrawal symptoms and reduce craving. Increase euphoria? I don't know.

I have been looking into some of the agonists that aren't commercially available, but I've not made any plans for which one I will give a shot.
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I ask this because of what you stated about it making simple enjoyment more enjoyable. Hypersexuality is another thing that was listed, as well as heightened orgasms.

So, I put the pleasure of orgasms to the same way we enjoy opiates.

So, theoretically, would you assume the same goes for various drugs that activate out reward system like sex, jogging and so on?...
 
Generally 'heightened' pleasure isn't a response. A greater drive for engaging in pleasurable activity is a response.

It increases the habit formingness of activity, not the actual enjoyment of the activity.

Someone described dopamine as a 'driving' chemical rather than a pleasurable one. It's not complete, but for these drugs it is an accurate description.
 
There are definitely drugs like SKF-81927 and friends that are self-administered. I don't think any of the ones used in medicine are so stimulating and self-administration-inducing...
 
Sekio, drugs such as that are used primarily for addiction research.

That's not that broad of a drug. It only effects one type of dopamine receptor as it's main effect.

I was thinking a broad dopamine agonist. One that hits most if not all of the human dopamine receptors.

Like the ones used in anti-depressant research.
 
There are definitely nootropic dopamine agonists too; don't get me wrong. But I'm not sure that there are any that act as broad "drug enhancers", especially those without side effects. I believe Jamshyd did some experiemtns with bromocriptine, give it a read?

Bromocriptine and other ergoloids have been used as "nootropics" and dementia/Alzheimer's treatments. Apomorphine is another notable name, but it's used medically to induce vomiting usually... From what I've read they seem, on the whole, unpleasant and useless for recreational purposes. Broad-spectrum dopamine activation can result in a whole bunch of crazy shit happening - vomiting and nausea, strange hypersexual compulsions, downregulation of natural dopamine pathways, etc.
 
sekio said:
There are definitely nootropic dopamine agonists too; don't get me wrong. But I'm not sure that there are any that act as broad "drug enhancers", especially those without side effects. I believe Jamshyd did some experiemtns with bromocriptine, give it a read?

Bromocriptine and other ergoloids have been used as "nootropics" and dementia/Alzheimer's treatments. Apomorphine is another notable name, but it's used medically to induce vomiting usually... From what I've read they seem, on the whole, unpleasant and useless for recreational purposes. Broad-spectrum dopamine activation can result in a whole bunch of crazy shit happening - vomiting and nausea, strange hypersexual compulsions, downregulation of natural dopamine pathways, etc.
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What I meant by broad as in Ropinirole broad.

I'm talking about the ones that are used in RLS.
 
Psychedelic Jay said:
What I meant by broad as in Ropinirole broad.

I'm talking about the ones that are used in RLS.
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Jay, I experienced euphoria alone from it, before I feel asleep last night. Stimulated and upbeat today. My 250 ug. dose of buprenorphine is moderately enhanced- and I am experienced with sub milligram doses, so it's not just the Nor-Bupe euphoria;

I'm not going to be using this drug for prolonged periods, I don't think I need excess dopamine, or rather lower level of dopamine post ropinirole. That's probably not quite accurate; Sekio, to the rescue?!
 
Some people get euphoria from it, others get psychotic reactions.

On a side note, another antiparkinsonian, l-dopa/carbidopa, feels very very nice and euphoric. Unfortunately I've heard tolerance goes up faster than any other drug though. But how can you expect just eating plain old dopamine wouldn't make ya feel good? I've seen no trip reports about this one the internet.
 
I was under the impression that consumption of l-dopa is not really a great idea, but the risk is outweighed by parkinson's disease. I could imagine it being psychoactive, in the same way as the russian drug that's basically a gaba analogue.
 
$linky said:
I was under the impression that consumption of l-dopa is not really a great idea, but the risk is outweighed by parkinson's disease. I could imagine it being psychoactive, in the same way as the russian drug that's basically a gaba analogue.
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It IS psychoactive. I can't really describe it, it feels very nice but a little weird/off. I only did it once. And also, IVing pills is not really a great idea yet people do that all the time:P
 
I've taken a lot of these, ropinirole, pramipexole, along with l-dopa/carbidopa.

L-dopa is psychoactive, and it certainly doesn't feel "nice." The first dose felt like a low dose of amphetamine to me. After that it felt generally shitty.

And it continues to get worse and worse the longer you take it. It does amazing things for Parkinson's, though. Is great for RLS too, but augmentation occurs far too rapidly.
 
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