I'm not too sure about baclofen, but I had a horrible reaction to DXM + phenibut. Uncontrollabe muscle twitching, unable to speak, nauseous, freezing cold curled in fetal position type bad. The doses were ~4gm phenibut & 300mg mxe, neither of which on its own caused negative reactions. Phenibut does have some effects that baclofen lacks. If you must try it, tread lightly.