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Qualitative differences in psychedelics while on SSRI

Sturnam

Sturnam

Bluelighter
Joined
Aug 12, 2008
Messages
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Now, I know there's a million 'can I trip on SSRI's' questions, but mine is a little more in depth and specific

I currently take 60 mg of cymbalta (duloxetine) daily, so it's on the higher end.

What I want to know is, will I be able to 'breakthrough' on DMT while on my SNRI? I saw one anectodal comment that said they were able to, but was wondering if anyone else had input.

Also, I'm wondering how it affects the various components of a psychedelic experience. I know SSRI's generally decrease the effects of psychedelics, but which effects are changed the most? For example, I'm looking at AMT and wondering how it will be affected. Decreased visual changes? Smaller headspace change? Decrease in the euphoric component that some people get?

In essence, will an SSRI decrease all effects of a psychedelic, or will there be a disparity in the decrease?
 
You might be able to break through on DMT while on an SSRI. DMT is an extremely strong agonist, it seems like nothing can stop it from working.

If you try, definitely report back with your findings. :)

Sorry I can't be of more assistance, I have no personal experience with SSRIs.
 
Definitely report back for us. I just got put on 10mg Lexapro and was wondering how much this would dilute the effects of LSD. I also was wondering if stopping the medication for a week before tripping could potentially make me have a stronger trip.
 
A week should be plenty of time for an SSRI to be out of your system, although I must say it's not recommended that you stop your medication, although I've done this before with SSRIs and been ok. If you've been on it a while then you could get withdrawal symptoms.
 
In my own experience and what i have seen with friends, mushrooms seem to work still fairly well. Lsd used to not work barely at all when I was taking ssris. Pretty much no visuals or mind fuck, maybe some brighter colors.
 
I was researching this just the other day; it seems that SSRI's stop some people from breaking through, but not everyone

So I guess there is only one way to find out! :)
 
I think it most likely depends on you and your body chemistry, but one of my best friends was unable to. haha it was really strange, because I helped him smoke it, manning the lighter and light bulb, watched him take several huge hits and not react in any way. He was on lexapro and he said he felt a mild body high, but nothing more. he later tried it after he was off the lexapro and it worked very very well. hopefully you have better luck :)
 
alantis360 said:
In my own experience and what i have seen with friends, mushrooms seem to work still fairly well. Lsd used to not work barely at all when I was taking ssris. Pretty much no visuals or mind fuck, maybe some brighter colors.
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Fuck. LSD is the main thing I'm concerned about. It is by far my favorite drug and I don't want to lose that magic just because of 10mg daily Lexapro. I just started it and will probably be tripping in 3 weeks (with maybe a few days of break before the trip) but I'm hoping I can still trip. Plus I really prefer Acid to mushrooms; there's no comparison in my opinion. I'm also bummed about giving up MDMA but I've been borderline abusing it lately and I think my brain could use some actual recovery time instead of just massive doses of 5-htp.

Would really like to hear of other people's experiences with SSRI's and tripping; particularly people who've been on 10mg Lexapro. Thanks.
 
ChronicHD said:
Fuck. LSD is the main thing I'm concerned about. It is by far my favorite drug and I don't want to lose that magic just because of 10mg daily Lexapro. I just started it and will probably be tripping in 3 weeks (with maybe a few days of break before the trip) but I'm hoping I can still trip. Plus I really prefer Acid to mushrooms; there's no comparison in my opinion. I'm also bummed about giving up MDMA but I've been borderline abusing it lately and I think my brain could use some actual recovery time instead of just massive doses of 5-htp.

Would really like to hear of other people's experiences with SSRI's and tripping; particularly people who've been on 10mg Lexapro. Thanks.
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Yeah man I was also prescribed lexapro. Mdma was hit or miss, sometimes I would roll pretty hard but always had to take more than usual. Lsd tho never worked, even if i took a high dose.
 
alantis360 said:
Yeah man I was also prescribed lexapro. Mdma was hit or miss, sometimes I would roll pretty hard but always had to take more than usual. Lsd tho never worked, even if i took a high dose.
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Are you talking about rolling while still on Lexapro? Or did you take a break before? I don't think I'd even attempt to roll without being off Lexapro for a few days. Not worth wasting a roll in my opinion.
 
I took LSD many times several years ago while I was on Lexapro (20mg), and then Cymbalta (120mg). I've never tripped while not on an SSRI/SNRI, but if my effects were blunted... holy shit. I really don't think they were in my case. I also rolled without a problem, but I had to take a little bit more than others, but I'm also overweight. I'd believe the MDMA was blunted by the meds, but I really don't think the LSD was.
 
ChronicHD said:
Are you talking about rolling while still on Lexapro? Or did you take a break before? I don't think I'd even attempt to roll without being off Lexapro for a few days. Not worth wasting a roll in my opinion.
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yeah sometimes I was able to roll good while on the lexapro
 
I wouldn't recommend going off your antidepressant in order to trip on psychedelics. First of all, many of them build up in your system and so they'll still be around after 3 days or so. Second, I wouldn't want to be in SSRI withdrawal during a trip. It just sounds awful.

Anyways, I'm working on extracting some DMT, so I may be able to report back on its effectiveness in a few weeks. I might not be able to get to it though, as I'm sick right now, and then I have finals coming up pretty soon.

But, I just had an idea for those of us on SSRI's. Maybe taking some piracetam or other -racetam for a couple days prior to a trip would enhance the psychedelic. It seems like piracetam definitely increases the effects of psychedelics for those not on SSRI's, so maybe it would 'normalize' the dosages for us, meaning we wouldn't have to take massive doses to trip.

I have some aniracetam laying around, so maybe once I get the AMT I can try combining them.

Note: I quickly looked up some piracetam + DMT reports, and they didn't sound very positive. The posters mentioned that it didn't feel 'right' or that something was off, or that they got very panicky.

If anyone has any input as to how the body high/feelings are changed with psychedelics, I'm especially interested in that. In the past, psychedelics have put me off a little due to uncomfortable physical sensations I experienced.
 
The next time I trip will probably be after I've only been on 10mg Lexapro for 2-3 weeks; is that enough time to start going through withdrawls? I thought you had to be on Lexapro for a longer time than that to withdrawl? Are there any cases of people not withdrawing?

How about tapering my dose down to 5mg daily for a week prior to the trip to lower the levels? As the post above asked, I would also be interested to hear about the body load associated with psychs and SSRIs
 
i used to take kanna recreationally (i don't requre SSRIs) and once i mixed it with HBWR seeds and another with a hit of lsd. don't remember it much, but i remember with the lsd there was little effect and with the hbwr it was quite intense after smoking a bunch of weed, pacing back and forth, imagining music in my head, hearing sounds clearly on the other side of my walls.. introspecting about things

i'd be engaging in pacing with anxiety when i just did kanna and smoked cannabis

but at that time i was quite fearful and had much anxiety, i have since calmed down. maybe something to do with dissociative abuse and its consequences.. something shulgin warned against among others
 
ChronicHD said:
The next time I trip will probably be after I've only been on 10mg Lexapro for 2-3 weeks; is that enough time to start going through withdrawls? I thought you had to be on Lexapro for a longer time than that to withdrawl? Are there any cases of people not withdrawing?

How about tapering my dose down to 5mg daily for a week prior to the trip to lower the levels? As the post above asked, I would also be interested to hear about the body load associated with psychs and SSRIs
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Well, the first time I experienced SSRI withdrawals were about 6 weeks after I started Pristiq (desvenlafaxine, which is actually an SNRI). I was on 50 mg (the lowest dose) and I kept getting the dreaded 'brain zaps,' which felt like for a split second I lost control of all my muscles. The worst part was going to sleep. I would semi-wake up, absolutely terrified but unable to move, until I actually 'woke up.'

Not sure how 2-3 weeks on 10 mg lexapro will feel, but personally I'm willing to take extra and try to 'breakthrough' rather than skip my dose. Not worth it to me. But I also think that 'pure' SSRI's, rather than SNRI's, have been associated with milder withdrawal symptoms. Don't quote me on that though, and as usual, YMMV.
 
^ What you're describing right up there sounds like sleep paralysis. I've dealt with this a bunch and it sucks. I'm pretty used to it by now, but it's still pretty scary when it happens. Basically my mind just wakes up before my body does and I can't move for a while. Very freaky stuff.

http://en.wikipedia.org/wiki/Sleep_paralysis
 
ChronicHD said:
Definitely report back for us. I just got put on 10mg Lexapro and was wondering how much this would dilute the effects of LSD. I also was wondering if stopping the medication for a week before tripping could potentially make me have a stronger trip.
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That's one way to guarantee a bad trip. Incredibly stupid idea, don't ever do this.
 
ChronicHD said:
^ What you're describing right up there sounds like sleep paralysis. I've dealt with this a bunch and it sucks. I'm pretty used to it by now, but it's still pretty scary when it happens. Basically my mind just wakes up before my body does and I can't move for a while. Very freaky stuff.
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Yup, two out of three nights experiencing that was more than enough to convince me to keep taking my SNRI. Totally not worth going without.

Anyways, my DMT experiences will have to wait. I've had some lung infection stuff that is being pretty persistent and isn't going away. So I think it's better to make sure it is completely gone before attempting to smoke any DMT.
 
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