Bravoncius Roxford
Bluelighter
- Joined
- Feb 1, 2017
- Messages
- 105
Hello, I am new here. I don't know if this is the appropriate forum, but I think it is.
I have a weird question regarding a supplement. I stopped using P5P recently because it depresses me. To be more precise, it makes me anxious and angsty. I see people everywhere claiming how this wonderful active form of vitamin B6 makes gives them well-being, increased energy, etc. Now, to me, the effect of P5P is biphasic: it first does make me feel more alive and happier, but 24-48 hours latter I feel like crap. When I take P5P, about 4-6 hours latter I feel more alive and my mood brightens. However, about a day latter I just get negative feelings, a very agitated state of worrying about stuff. Basically, it makes me feel "uneasy". That is the word. I just feel uneasy, like I can't relax emotionally. Does anyone have similar experience? Probably not.
I was thinking about hypothesis for why P5P makes me feel this way. P5P is an enzyme co-factor for a lot of reaction in the body. Among them, is the conversion of 5-hydroxytrptophan into serotoin and l-dop into dopamine, as well as l-typtophan inot niacin.
Taking this into consideration and judging how P5P makes me feel, I have considered this: the first effect, increased feelings of aliveness and brightened mood, are probably caused by increased conversion of l-dopa into dopamine. I have taken a lot of dopaminergics in the past(amphetamine, methylphenidate, selegiline, rasagiline, etc) to know that this effect is dopaminergic. However, what I cannot explain is the deep feeling of angst and worry that I get one or two days latter. Considering the actions of P5P, I have considered three hypothesis:
1. P5P increases the conversion of l-dopa into dopamine, using up most of the decarboxylase enzyme and leaving little to convert 5-HTP into serotonin, leading to serotonin depletion.. Because tyrosine crosses the blood-brain barrier more effectively than tryptophan, and because both l-dopa and 5-HTP uses the same decarboxylase enzyme for conversion, the decarboxylase enzyme gets used up converting l-dopa into dopamine when a lot of P5P is available, so there is little left for converting the 5-HTP into serotonin. So the anxious and angsty feeling is caused by depletion of serotonin.
2. P5P actually increases the conversion of 5-HTP into serotonin, which in turn stimulates 5-HT1 and 5-HT2c receptors, triggering anxiety and restleness. So the feelings caused by P5P are due to increased serotonin.
3. P5P increases the conversion of typtophan into niacin, making less typtophan available to be converted into 5-HTP and latter into serotonin. So the feelings caused by P5P are due to serotonin depletion.
The reason why understaind the etiology of the anxiety and angst triggered by P5P is because both low and high levels of serotonin can cause anxiety and angst. If serotonin linearly either increased or decreased anxiety according to level, then I could counter the anxiogenic effects of P5P by taking typtophan, 5-HTP or eating lower carbs with more BCAAs(which lower serotonin). But because 5-HTP has dual effects, then it is impossible to device a strategy to counter the effects.
What do you guys think?
I have a weird question regarding a supplement. I stopped using P5P recently because it depresses me. To be more precise, it makes me anxious and angsty. I see people everywhere claiming how this wonderful active form of vitamin B6 makes gives them well-being, increased energy, etc. Now, to me, the effect of P5P is biphasic: it first does make me feel more alive and happier, but 24-48 hours latter I feel like crap. When I take P5P, about 4-6 hours latter I feel more alive and my mood brightens. However, about a day latter I just get negative feelings, a very agitated state of worrying about stuff. Basically, it makes me feel "uneasy". That is the word. I just feel uneasy, like I can't relax emotionally. Does anyone have similar experience? Probably not.
I was thinking about hypothesis for why P5P makes me feel this way. P5P is an enzyme co-factor for a lot of reaction in the body. Among them, is the conversion of 5-hydroxytrptophan into serotoin and l-dop into dopamine, as well as l-typtophan inot niacin.
Taking this into consideration and judging how P5P makes me feel, I have considered this: the first effect, increased feelings of aliveness and brightened mood, are probably caused by increased conversion of l-dopa into dopamine. I have taken a lot of dopaminergics in the past(amphetamine, methylphenidate, selegiline, rasagiline, etc) to know that this effect is dopaminergic. However, what I cannot explain is the deep feeling of angst and worry that I get one or two days latter. Considering the actions of P5P, I have considered three hypothesis:
1. P5P increases the conversion of l-dopa into dopamine, using up most of the decarboxylase enzyme and leaving little to convert 5-HTP into serotonin, leading to serotonin depletion.. Because tyrosine crosses the blood-brain barrier more effectively than tryptophan, and because both l-dopa and 5-HTP uses the same decarboxylase enzyme for conversion, the decarboxylase enzyme gets used up converting l-dopa into dopamine when a lot of P5P is available, so there is little left for converting the 5-HTP into serotonin. So the anxious and angsty feeling is caused by depletion of serotonin.
2. P5P actually increases the conversion of 5-HTP into serotonin, which in turn stimulates 5-HT1 and 5-HT2c receptors, triggering anxiety and restleness. So the feelings caused by P5P are due to increased serotonin.
3. P5P increases the conversion of typtophan into niacin, making less typtophan available to be converted into 5-HTP and latter into serotonin. So the feelings caused by P5P are due to serotonin depletion.
The reason why understaind the etiology of the anxiety and angst triggered by P5P is because both low and high levels of serotonin can cause anxiety and angst. If serotonin linearly either increased or decreased anxiety according to level, then I could counter the anxiogenic effects of P5P by taking typtophan, 5-HTP or eating lower carbs with more BCAAs(which lower serotonin). But because 5-HTP has dual effects, then it is impossible to device a strategy to counter the effects.
What do you guys think?