Nagelfar
Bluelight Crew
putative novel transitional metabolites by dynamic interaction of 1< exogenous drugs
e.g. cocaine + ethanol (ethyl alcohol) = cocaethylene
e.g. cocaine + vanillin (the molecule responsible for the flavor of the vanilla orchid) = methyl-'metamethyoxy-para-hydroxyl-cocaine (or simply methyl-vanillyl-ecgonine)
I also postulated some time ago, seeing as menthol is an alcohol technically, and it had even been found as a cutting agent in street cocaine to contribute to the anesthetic sensation to mask the adulteration, that the carbmethoxy may change accordingly as like with ethanol; "cocamentholene"
Well I've had additional considerations occur to me just now, though I would value the input of someone with the knowledge of what is liable to make for a labile bond that would form a new third and new (perhaps unprecedented with regard to discovery or even postulation) compound via the metabolic pathways in vivo of two or more exogenous (the opposite of "endogenous" and by contrast meaning not occurring in the body naturally but having been administered, imbibed, ingested, infused, etc.) drugs.
Well different kinds of alcohol, beers and wines, have fermentation products which give them differing smells and tastes. For instance, looking at 4-ethylguaiacol it doesn't have the portion which would emulate the benzoylmethoxy in shadowing the basic cocaine skeleton. But looking at the potential analogs, specifically the compounds Singh's antagonists paper numbered 229—232 , the benzyl replacing the benzoyloxy; and still a functional drug; well the above 4-ethylguaiacol's presence in certain specific beers and wines would, if replaced at where the methylbenzoate is cleaved in cocaine's manner of metabolism; the "ethyl" in 4-ethylguaiacol, if bound to the 3 position of the tropane would likely make a cocaine analog as a transitional product in vivo; since it would also be subject to transesterification at the carbmethoxy too; it would make the cocaethylene equivalent as another byproduct. Essentially, this "4-ethylguaiacol" cocaine analogue being the benzyl equivalent of the benzoyloxy ring subsitutions of methylvanillylecgonine.
If these were actually looked for, how likely is it they'd be found, would someone care to venture a guess?
More later.
e.g. cocaine + ethanol (ethyl alcohol) = cocaethylene
e.g. cocaine + vanillin (the molecule responsible for the flavor of the vanilla orchid) = methyl-'metamethyoxy-para-hydroxyl-cocaine (or simply methyl-vanillyl-ecgonine)
I also postulated some time ago, seeing as menthol is an alcohol technically, and it had even been found as a cutting agent in street cocaine to contribute to the anesthetic sensation to mask the adulteration, that the carbmethoxy may change accordingly as like with ethanol; "cocamentholene"
Well I've had additional considerations occur to me just now, though I would value the input of someone with the knowledge of what is liable to make for a labile bond that would form a new third and new (perhaps unprecedented with regard to discovery or even postulation) compound via the metabolic pathways in vivo of two or more exogenous (the opposite of "endogenous" and by contrast meaning not occurring in the body naturally but having been administered, imbibed, ingested, infused, etc.) drugs.
Well different kinds of alcohol, beers and wines, have fermentation products which give them differing smells and tastes. For instance, looking at 4-ethylguaiacol it doesn't have the portion which would emulate the benzoylmethoxy in shadowing the basic cocaine skeleton. But looking at the potential analogs, specifically the compounds Singh's antagonists paper numbered 229—232 , the benzyl replacing the benzoyloxy; and still a functional drug; well the above 4-ethylguaiacol's presence in certain specific beers and wines would, if replaced at where the methylbenzoate is cleaved in cocaine's manner of metabolism; the "ethyl" in 4-ethylguaiacol, if bound to the 3 position of the tropane would likely make a cocaine analog as a transitional product in vivo; since it would also be subject to transesterification at the carbmethoxy too; it would make the cocaethylene equivalent as another byproduct. Essentially, this "4-ethylguaiacol" cocaine analogue being the benzyl equivalent of the benzoyloxy ring subsitutions of methylvanillylecgonine.
If these were actually looked for, how likely is it they'd be found, would someone care to venture a guess?
More later.
