Look at 3-MeO-PCP and how it can cause manic thoughts related to solving some ultimate mystery. I'm not exactly sure what circuits of the brain are involved but I suspect there are ones related to confidence and solving or answering, completing or achieving something at play just like I subscribe to the theory that strong stimulation of circuits related to novelty of an experience can lead to feeling like you are doing something for the first time (a difference is, you can often still rationalize that in fact it is not actually the first time you are doing something while tripping).
There may be inhibitory aspects of the action of drugs like ketamine that give it reduced potential for such manic effects compared to PCP and 3-MeO-PCP, well at least with S-ketamine - IME with the R isomer you can still get such effects.
The confidence I mentioned actually seems more like a by-product of numbness / painlessness, the combination can make you feel invulnerable. Though it may at the same time be related to reward pathways.
Dissociatives seem weird, some of the effects may just be due to regular properties of the mind going unchecked by others - regular aspects being without control.
Anyway, nitrous is an NMDA antagonist too but of course highly numbing and with very quickly peaking kinetics. How is the cosmic joke not kind of like a compressed psychedelic and manic 3-MeO-PCP sort of flash at that peak after which it just drops off again and upon coming down regular thought patterns come online again. If the effects are illusory like I think they are it is not surprising that it feels intangible when we try to integrate it or piece it back together. Even when some elements are pieced together the feeling of having found the key is bound to be missing.
(Not that trips aren't often creative or that they can't involve problem solving or out of the box associations.)
Now that I think about it, it occurs to me that both stimulants and dissociatives can ultimately feel initially rewarding but ultimately unredeeming in this effect. Stims involve less illusion and for it is more directly apparent to me that the effects are inherently empty and make mostly sense when we use them to do things which then are rewarding. Disso's "work well" as escapist drugs but that is quite another thing.
There may be inhibitory aspects of the action of drugs like ketamine that give it reduced potential for such manic effects compared to PCP and 3-MeO-PCP, well at least with S-ketamine - IME with the R isomer you can still get such effects.
The confidence I mentioned actually seems more like a by-product of numbness / painlessness, the combination can make you feel invulnerable. Though it may at the same time be related to reward pathways.
Dissociatives seem weird, some of the effects may just be due to regular properties of the mind going unchecked by others - regular aspects being without control.
Anyway, nitrous is an NMDA antagonist too but of course highly numbing and with very quickly peaking kinetics. How is the cosmic joke not kind of like a compressed psychedelic and manic 3-MeO-PCP sort of flash at that peak after which it just drops off again and upon coming down regular thought patterns come online again. If the effects are illusory like I think they are it is not surprising that it feels intangible when we try to integrate it or piece it back together. Even when some elements are pieced together the feeling of having found the key is bound to be missing.
(Not that trips aren't often creative or that they can't involve problem solving or out of the box associations.)
Now that I think about it, it occurs to me that both stimulants and dissociatives can ultimately feel initially rewarding but ultimately unredeeming in this effect. Stims involve less illusion and for it is more directly apparent to me that the effects are inherently empty and make mostly sense when we use them to do things which then are rewarding. Disso's "work well" as escapist drugs but that is quite another thing.
Last edited: