Psychedelic Opiates ?

[Rectify]

There Is A Dissociative Pharmacophore In DXM Somewhere.

 

[Opana313]

SWEET_CAROLINE
N-dodecyl-2-amino-1-(3,4-methylenedioxyphenyl)-propane

Sassy!

Who's this sassy structure, or well is this what OP is after? Forgive me chemistry is not my skillset

 

[Opana313]

Sorry for the AI paste.

This compound is structurally related to MDMA (\(N\)-methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane), a controlled psychoactive substance, but with a longer N-dodecyl chain (12 carbons) instead of the N-methyl group. Due to its structural similarity to regulated amphetamine-type stimulants and the common use of 3,4-methylenedioxyphenyl compounds as precursors in illicit drug synthesis, it is potentially a controlled or regulated substance.

Sooo well yeah ok I get it. I think?...I forgot there are very stimulant like psyches out there from 2C compounds or others?

 

[4DQSAR]

@TheLightBringer - Long ago I posted a link to a patent in which a class of ring (and/or) N substituted tetrahydrobenzacine was demonstrated to be a (weak) opioid. One of the names on the patent was Shetty. I think he was also named on the nexeridine patent. Put bluntly, if you use Google Patent to follow his career, he seemed to change his employer to one who would allow him to research opioids. It's quite sad BUT it's also a signal warning. Do not study medicinal chemistry if you are really only interested in one class of compound because MOST candidates never reach the market.

It looks like ibogane is quite promiscuous. Which is fine as it's subjective activity was well understood by the indigenous cultures that make use of it.

But I don't think it controversial to suggest that the work of Paul Ehrlich CC 'the magic bullet' is still considered to be highly desirable. Look at the side-effect profile of antipsychotics. Who knows what such promiscuous medications REALLY do to the human body.

I will stop. Or this will be a rant on how better antipsychotics exist, but the only work for subsets of sufferers. So it's less profitable and never mind how much damage neuroleptics cause.

But honestly - just take two things. Especially if you aren't in the position to subject a candidate to the same specifications as any new synthetic medicine. I explained how we threw away a lot of work because we couldn't ensure safety. Killing users is possibly the MOST effective way to end up at the top of a list you don't even want to be on.

Drug Development & Approval Process

Get to know FDA’s drug development and approval process -- ensuring that drugs work and that the benefits outweigh their known risks.

www.fda.gov

Human regulatory: overview | European Medicines Agency (EMA)

Information on the regulation of medicines for human use in the European Union (EU), with a focus on the centralised procedure. The European Medicines Agency (EMA) plays a key role in this procedure.

www.ema.europa.eu

I've never had to subject a candidate to FDA requirements although I think it's important to note that the FDA has demonstrated more risk aversion than virtually any other nation on the planet. Why isn't Frances Oldham Kelsey honoured? The whole world now tests for teratoxicity because of her work. But I can tell you that before it went digital, if a research laboratory in the UK had a candidate, they got sent two forms. I say form but they were actually spine-clipped books. One was about a thousand pages, the other about one thousand one hundred pages and as testing progresses, tens of thousands of items need to be filled in (in block capitals).

Honestly, it's such a complex task that now most pharmacutical companies will employ a company who does all of the testing and let me tell you, even the very simplest in vivo testing in single-cell organisms costs millions.

 

[dydst]

I've looked at Pentazocine. It doesn't contain the duality of Serotonin activity and Opioid activity I want to look into.

Yes I believe it’s effects are more dysphoric than psychedelic, and that is due to it’s KOR reception activity.