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Psychedelic Opiates ?

MedicinalUser247

MedicinalUser247

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" 3,4-Methylenedioxynitazene is a Benzimidazole derivative which has been sold as a designer drug over the internet and presumably has Opioid effects. It is an analogue of Etonitazene where the Benzyl ring is substituted with a 3,4-Methylenedioxy ring system rather than an Ethoxy group. " ( Quoted from Wikipedia. ) https://en.wikipedia.org/wiki/Methylenedioxynitazene

My question is how common are Psychedelic Opiates and what are the actual effects ?
 
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Where was it stated that it would have psychedelic effects? I dont know of any compound which is sufficiently strong as a 5HT2A agonist and mu-Opioid agonist to cause significant effects of both classes simultaneously.


There are hallucinogenic opioids/opiates through K-opioid agonism but not psychedelic ones.
 
Sounds interesting.

Good old broon can be psychedelic too especially when smoked with good ganja.
 
MedicinalUser247 said:
" 3,4-Methylenedioxynitazene is a Benzimidazole derivative which has been sold as a designer drug over the internet and presumably has Opioid effects. It is an analogue of Etonitazene where the Benzyl ring is substituted with a 3,4-Methylenedioxy ring system rather than an Ethoxy group. " ( Quoted from Wikipedia. ) https://en.wikipedia.org/wiki/Methylenedioxynitazene

My question is how common are Psychedelic Opiates and what are the actual effects ?
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what makes you think it has effects similar to psychedelics?
 
MedicinalUser247 said:
Because it contains a Methylenedioxy structure.
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That doesnt make sense, MDPV, Streptovaricin and Berberine are examples of compounds with a Methylenedioxy moiety. None of them have any serotonergic activity. A methylenedioxy ring doesnt translate to any serotonergic or psychedelic activity.


Its like looking at a compound with a phenethyl group attached to it and saying ”oh it ought to have stimulant activity!” An example being fentanyl, which is quite the opposite of a stimulant
 
TheLightBringer said:
That doesnt make sense, MDPV, Streptovaricin and Berberine are examples of compounds with a Methylenedioxy moiety. None of them have any serotonergic activity. A methylenedioxy ring doesnt translate to any serotonergic or psychedelic activity.


Its like looking at a compound with a phenethyl group attached to it and saying ”oh it ought to have stimulant activity!” An example being fentanyl, which is quite the opposite of a stimulant
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Your exactly the kind of person I want to have a conversation with.
 
I've looked at Pentazocine. It doesn't contain the duality of Serotonin activity and Opioid activity I want to look into.
 
Closest thing to what you're asking, but far off by a long shot, is tramadol, with it being an atypical opioid which also acts as an SNRI. Definitely not psychedelic but some people find the headspace it gives a bit trippy in its own way.
 
Smyth2 said:
Did u see the analogs where there is a fusion between 2cb and fentanyl.

commons.wikimedia.org

File:N-(2C-B)-fentanyl structure.png - Wikimedia Commons

commons.wikimedia.org commons.wikimedia.org

I asked a year or two ago if anyone had a citation for any of these compounds but no one could seem to find one.

Most of the trippy opiates are kappa agonists but I think you knew that already.
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This is the kind of Scientific research I love to see ! I just love it ! :love:
 
Smyth2 said:
Did u see the analogs where there is a fusion between 2cb and fentanyl.

commons.wikimedia.org

File:N-(2C-B)-fentanyl structure.png - Wikimedia Commons

commons.wikimedia.org commons.wikimedia.org

I asked a year or two ago if anyone had a citation for any of these compounds but no one could seem to find one.

Most of the trippy opiates are kappa agonists but I think you knew that already.
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Ive seen these too and they look really cool I think I saw DOx fentanyls as well and some other phenethylamines. However Im 99,9% sure they would be inactive as psychedelics and if active as Opioids then they would be significantly weaker than fentanyl. With some luck they act as a prodrug to both fentanyl and 2C-x drugs which is still unlikely
 
KOR ligands are very common and very 'psychedelic' but also HUGELY dysphoric. Sure, you could bind an MOP to a psychedelic with a labile bond but that's rather limited because with a 1:1 ratio, unless the two are equally potent, it's not going to work. Even then, it assumes the two are equally active.

Sorry if this sounds INSANE - but take a psychedelic AND an opioid since everyone is different so the optimal ratio will differ between users.

In the 1960s I think a few opposing compounds were thus combined. I'm almost sure someone bound a stimulant to a sedative so only anoretic activity remained. But they all seemed to come and go in about a decade and suggest that side-effects were the issue. Either too stimulating or too sedating.

I will conclude by noting some insane person asked the Chinese to produce the 2,5-dimethoxy-4-bromo derivatives of everything from opioids to sedatives to stimulants and I cannot find a single report so I suggest a vendor offered them briefly and people worked out that QSAR might be a bit more complex than they had thought...
 
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