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Psychedelic methcathinones

Solipsis

Solipsis

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OK I can't find a single bit on this, i call dibs on 4-x-2,5-dimethoxymethcathinones!

It is said that psychedelic cathinones are totally unstable, but those aren't necessary or even possible precursors for the secondary amines right?
Please if someone has any advanced chemical info on this corner of research I would love to have it. Also, I'm interested to know if there would be major bumps in the synthesizing road and speculation on the effects.
Methcathinones are supposed to have a not so big body load and hangover, also they should be more of a rush than other PEAs. I'm dreaming of a sparkling but deep and fast ride through a euphoric psychedelic state.
 
simple secondary amines are as a rule not very good agonists at 5ht2a.
 
Only way I could see it working is to make an N-substituted prodrug that gets metabolised to the primary amine in vivo so that its stable on synthesis and storage but then once its in the body the concentration of the cathinone is too low for dimerisation to occur.

If you can make an N-OH then presumably you could also make N-acetoxy, and I would expect that would get cleaved pretty fast to NH2 once it was inside the body.
 
The issue is that they dimerise, right? Isn't this solvable by converting to a salt right away? More I'm missing?

Anyway, the cathinones are worse for everything. Worse stimulants, and generally worthless psychedelics. The beta-methoxys were good though, right?
 
What about protection in the form of a pthalimidopropiophenone, are the 2,5-diMeO-cats (not methcats etc ofcourse) psychedelic?

I think a pthalimidopropiophenone SHOULD cleave to a cat in vivo as soon as it gets slapped around by some stomach acid, no?

If so, might be (in the UK at least) a way to get to the cathinones that the angel Gabriel himself might smile upon.
 
Thanks for clearing up the 5-HT2a agonism and dimerisation dilemma, would this mean my proposed molecule would be pretty impotent as a psychedelic and possibly also impotent as even an entheogen because both ways of activity are like mutually excluded? Hmm let this simmer in my mind for a bit. I'm beginning to understand there is some division of disagreeable pharmacologies.
 
I believe the dimerisation is base-catalysed, so purification as well as synthesis could be a royal pain in the bollocks.
 
N-benzyl (of the 2-methoxy substituted kind, probably) psychedelic cathinones, anyone? Two birds with one stone so to speak.
 
I think psychedelic cathinones, rather than psychedelic methcathinones, are what you are looking for. If MDC (3,4-methylenedioxycathinone) can be made--and it can btw b/c I saw a paper on it around here not too long ago--then I don't see any reason why 3,4,5-trimethoxycathinone couldn't be made either. It's not impossible; it just has to be done right.
 
As Hammilton said,target the salt and you'll get a stable compound.Lets say the last step remove BOC with HCl to get primary cathinonhydrochloride.It might degrade in you body again more easily,but the a little less duration from for example DOM can't be that bad.
 
A friend of mine synthed Bk-2C-B recently. He is wary of letting me go guinea pigging though.
 
They are all just placebos you retards. HAHA DONT YOU FEEL LIKE A RETARD
now that you know it was placebo???

Grow up & stop with the petulant, foot stamping tantrum consisting of 'placebo' comments in every thread
 
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