Psychedelic Cathinone Analogues.

[MagickalKat777]

the pharmacological profile of 4-bromo-2,5-dimethoxy-cathinone would be similar to DOB's, yes, but the functions would most likely not be synonymous, and the effects would be different enough, i imagine, to be worth persuing, especially if methylone is any sort of indicator of how psychedelic cathinones would compare to their amphetamine counterparts.

I agree, however, whoever pursues this could get in a lot of trouble governmentwise, and I wouldn't recommend it. This chemical will no doubt be analogous to either DOB or 2C-B, and either way, I wouldn't recommend trying to pursue it. It isn't worth the legal risk and most definitely *could* be prosecuted under the analog act, especially with cathinone being recognized as an amphetamine analog. That is my take on it though.

 

[tathra]

who said anything about pursuing these just as recreational drugs? we're talking about unexplored chemicals here that would potentially be quite useful for research in nuclear medicine (using radioactive isotypes of bromine/iodine/etc and tracking the chemicals' progress through the body), especially if the cathinone derivatives are as easy to make as the amphetamines (elemental bromination/iodination/etc after disolving in GAA)... plus the whole aspect of creating a chemcal that nobody else has ever made before (well, i'm sure somebody has done it, but i've never heard of any documentation for it)

for legitimate research, ie not just for getting high, it is most definately worth pursuing

 

[classbhero]

Hello,

I am interested in having a company synthesis some Cathinone analogues of psychedelic phenethylamines such as 2C-B and DOI etc.

Does anyone have any information, especially on what the 4-Bromo-2,5-dimethoxy-Cathinone molecule would look like and any routes of synthesis.

These could be some very interesting and currently legal compounds.

Jack

 

[Swerlz]

I suggest you read this

http://www.erowid.org/archive/rhodium/chemistry/cathinine.txt

 

[classbhero]

I had that page open already. but thanks.

 

[Solipsis]

I have wondered about this like you, but the answer to this I got was that the empathogenic (or whatever) cathinone effect is significantly different from psychedelic effects. My attempt to paraphrase it is that cathinones function in manners related to monoamine release or reuptake inhibition, not agonism. If you would attempt to make a crossover molecule that structurally signifies the bridge between empathogens/cathinones and psychedelics the result would unfortunately just not be impressive, like attempting to succeed in both respects but failing at them both, a miserable concession. Hopefully I got this right, I'm not speaking from expertise - of course it could alway be that I'm grossly mistaken.

Personally I found the concept very promising!! But it appeared to me there is a reason this class is not pursued.

 

[dread]

A cathinone with a primary amine would easily dimerize into the corresponding piperazine. Thus potency would be very low, and side effects from the piperazine analogue would probably suck.

 

[Quanta]

A cathinone with a primary amine would easily dimerize into the corresponding piperazine. Thus potency would be very low, and side effects from the piperazine analogue would probably suck.

You're correct in the primary amines propensity to dimerize but the dimer product would likely be aromatic pyrazines and not piperazines.

With the loss of potency and increase in toxicity, I don't see much point in pursuing these compounds.

 

[Solipsis]

O yeah forgot about that one, but that's just a bump in the road that is there with the empathogenics as well. If you were to synthesize a secondary amine (if not tertiary but lets not confuse it more) then the relevant part about psychedelic (N-alkyl)cathinones comes into focus.
Already spilled my 2 cents on that, interested to hear alternative opinions.

Merged with another thread about these compounds, check post #14 from Jamshyd for at least 1 supposed valid result.

 

[OGRE_FOOT]

I took a half gram of one marketed as "Brilliance Good Luck Powder." Everything became cloudy and I had trails. It gave definite visuals. Everything I looked at had extra layers over the actual object.

 

[ToxicFerret]

Um, cam you be any more specific as to what chemical you took? Random powder named like a Chinese restaurant is a bit sketch.

 

[blowjay]

Kinda bumping this due to realizing that it could give some crazy options such as a cathinone version of 2c-b. If anyone can add any guesses to why these aren't being made just to play around with and see what they do. Surely they can't all just be 'meh', so many people like 4-MMC and 2C-B, just puzzles me why all these weird cathinones are made yet nobody plays in semi-familiar area.