propylhexedrine question

[shepj]

How come research chem. labs have used shit like amphetamine and methcathinone for research chems but they haven't touched on something like propylhexedrine? Is it really that difficult to modify in order to change it into a designer? I heard someone mention something about
3,4- methylenedioxypropylhexedrine but I didn't know if that is even possible or not?

 

[fastandbulbous]

Because for anything other than the stimulant effect, you need to have an aromatic ring (eg phenyl) - a fully saturated cyclohexyl ring just doesn't work

 

[nuke]

Basically because it's a shitty stimulant with a large amount of toxicity associated with it.

 

[negrogesic]

3,4- methylenedioxypropylhexedrine

Enough with these!

 

[shepj]

Thanks for the replies, and also thanks for clarifying that for me.

 

[fastandbulbous]

Psychedelics need to be flat as possible for best receptor interaction. Benzene (amphetamines) is flat (planar) but cyclohexane (propylhexedrine) isn't (boat or chair conformation)

 

[wungchow]

Propylhexedrine has unique entactogenic effects, probably a result of some of those stray methylene groups outside of the normal "plane" of typical stimulants.

I think a keto group at the 3 or 4-position of the cyclohexane ring would be a worthy modification.

 

[stirfry]

off topic, but......


does anyone know which receptors propylhexedrine binds to, and in what ratio? why is it so hard to find receptor binding info on this substance, it's been around forever.

 

[Hammilton]

It was never really researched as a drug of abuse though. I would imagine that it's pretty much like a more adrenergic version of amphetamine, and probably causes some more SE efflux.

 

[Hammilton]

I'm terrible at reading these things but does this say that PHX is an ORL ligand?

 

[dread]

I wonder what would happen if you replaced the cyclohexane with a cyclohexadiene?

Since I got nothing better to do might as well draw it up:

 

[johanneschimpo]

I have to suppose it would help, as it would increase the rigidity (planarity) of the ring. I think I read something about using a cyclohexene ring before, but I don't remember the results. (sorry!)

 

[Pomzazed]

@dread and johan:
I've had that topic somewhere at blacklight a long time ago.
Edit : but diene looks sucks to me on reactivity, esp if it is conjugated, it might go cycloaddition with another -ene somewhere in the body.

 

[fastandbulbous]

Or the dread epoxidation, turning it into something that binds to DNA (and all the nasty things that go with it). At least when it's saturated this can't happen - it's the way the body deals with aromatic hydrocarbons (& hence why they're carcinogenic).

Much better off replacing the cyclohexyl ring with some other aromatic heterocyclic, like thiophene or furan

 

[MurphyClox]

does anyone know which receptors propylhexedrine binds to, and in what ratio? why is it so hard to find receptor binding info on this substance, it's been around forever.

In general, I would think that it binds to the same receptors like methamphetamine, just worse. Didn't find more specific data.

 

[ebola?]

It was never really researched as a drug of abuse though. I would imagine that it's pretty much like a more adrenergic version of amphetamine, and probably causes some more SE efflux.

This would be my guess too, but I don't like guessing binding affinities via bioassays. I tried to find some lit. on its pharmacology a while back but failed.

Much better off replacing the cyclohexyl ring with some other aromatic heterocyclic, like thiophene or furan

I'd opt for a phenyl group.

ebola

 

[shepj]

I'd opt for a phenyl group.

ebola

lol.. but that defeats the purpose out of making a new designer drug from propylhexedrine.

So, we have a lack of information about PHX, how do people know that it is so toxic then?

 

[wungchow]

I doubt PHX is any more toxic than amphetamine or methamphetamine.

Problem is, it's only available in combination with menthol, lavender oil, and a big piece of cotton. And extraction is a pain in the butt.

 

[wungchow]

I still think PHX substituted with a carbonyl oxygen on the ring would be a worthwhile compound.

 

[shepj]

I doubt PHX is any more toxic than amphetamine or methamphetamine.

Problem is, it's only available in combination with menthol, lavender oil, and a big piece of cotton. And extraction is a pain in the butt.

Right. I don't about the extraction being a pain though, I have it down to a very short ass process and the results are amazing.. hell I don't even know what lavendar burps are this shit is so clean.