propylhexedrine & neurotoxicity

[infestedpasta]

Does anyone here know how neurotoxic pure propylhexedrine would be on the brain compared to things like Methamphetamine, amphetamine or MDMA?

Thanks.

 

[TheAzo]

I think it's probably less neurotoxic. Saying this on the grounds that the neurotoxicity of the others is linked to their strong monoamine releasing effects, and propylhexedrine is a piss poor stimulant - if it's a releaser and not an RI, it's a weak one. Also, afaik, amphetamine/meth, which are most similar to propylhexadrine only present problematic neurotoxicity over chronic/heavy use.

I'd be much more worried about the peripheral effects than the neurotoxicity. While it's a shitty central stimulant, it's a pretty good peripheral stimulant - which is bad. It always felt really fucking unhealthy (rapid heartbeat, palpitations, etc), even at very low doses, when i was experimenting with it.

 

[indelibleface]

On the contrary, I always sort of liked propylhexedrine. In fact, I always felt there was a mild serotonergic component to the drug, and it has a strong synergy with nitrous oxide. In reasonable doses (meaning one inhaler spaced out over an evening) it makes for a nice diversion, and it`s great for homework or cleaning. To each their own, I guess.

 

[ebola?]

I'm a fan of the first 6 hours. On the other hand, I don't need to stay up with jittery stimulation for 12+ after that (this is with doses restricted to 250 mg). I also get visuals from it that resemble those of cannabis, with an inexplicably strong synergy with nitrous (resembling nitrous + mdma).

P-hex is methamp with a cyclohexane replacing the phenyl group in the phenethylamine backbone, so insofar as p-hex is psychoactive, it likely presents dangers of neurotoxicity similar to meth's.

Also, given its severe cardio-load, we might expect dangers of localized, mild hypoxia in the brain, so it's likely highly inappropriate for long-term use. For according reasons, people appear to die when they IV this.

I've searched far and wide for research on receptor affinities, etc., but I think that it's simply not there, as the manufacturer never expected people to take 200x the therapeutic dose.

ebola

 

[simstimstar]

I would personally be more worried about cardiotoxicity. Having tried it a few times, I can say it feels hard on the heart. Like if you lay on your back while on propylhex you will be able to see your heart beating in your upper abdomen like you just got done running or you have had too much ephedrine.

I used to use propylhexedrine back in high school occasionally, but only because there was nothing else available and it seems to be more centrally active than ephedrine, but still not that much. I have not touched it since then. I do think that abusing ephedrine and propylhexedrine in high school directly led to my later use and abuse of amphetamine, meth, and coke. I did use it a fair bit back in the day, even made a couple posts about it back when I was 'Dogtoy' on here, before I lost the password and email account that was associated with that account some time ago. I was a bluelighter on THAT account, but not the new one yet.

 

[psood0nym]

I'm pretty certain for those who get the best effects, as with meth, it's releasing a substantial amount of serotonin along with the other suspected monoamines. On a dose of ~325 mg my vision gets liquidy and my coordination is noticeably affected (for most this dose would be too much). At that dose it feels like a meth bomb MDMA pill to me (the only time I've used meth crystal I also took MDMA, so I can't compare it to meth directly). I don't get the annoying peripheral effects others describe except for vasoconstriction, either. Perhaps more is getting to my brain than the average user's. I have no idea why this would be, but, given the chemical similarity, if it feels like meth to you then it's probably almost as bad as meth for you, maybe even worse. Intravenous use reportedly causes brainstem dysfunction. I try to keep it to 3 times per year or under.

 

[ebola?]

As for neurotoxicity.. after high dose recreational use the crash is similar to that of amphetamine and methamphetamine from my experience.

Why would the degree of 'crash' be a reliable and valid indicator of neurotoxicity?

I'm pretty certain for those who get the best effects, as with meth, it's releasing a substantial amount of serotonin.

my intuition too, but there are some discrepancies in my experience:
1. the synergy with nitrous vastly eclipses that with meth, yet the p-hex high lacks much of the presumed '5ht feel' of mdma and other entactogens.
1a. I hypothesize that adrenergic agonism, coupled with NE release, effects disproportionately strong tactile effects, that many analogize to those of entactogens-proper.
1b. However, the above doesn't explain the synergy with N2o.
2. As I said earlier, the visuals resemble those of cannabis or dissociatives-proper to a far greater extent than they do the 'mdma sparkle'. Could p-hex exert any NMDA-antagonism? IIRC, the cyclohexyl group precludes 5ht2a agonism...I'm guessing CB1 agonism highly unlikely.
3. The visuals and nitrous potentiation manifest most strongly near the end of the high. I have no explanation for this. I just REALLY hope that the mechanism for visuals isn't hypoxia localized to visual corteces, nor the mechanism for the 'fuzziness' of the high an alternate neural hypoxia.

I've badgered this forum with such questions repeatedly; the data's simply not there. :/
My above speculations add little, given everyone's idiosyncrasies.

ebola
ebola